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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SNTB2

Summary for SNTB2

Gene information	Gene symbol	SNTB2
	Ensembl ID	ENSG00000260873
	Entrez ID	6645
	Gene name	syntrophin beta 2
	Synonyms	D16S2531E\|EST25263\|SNT2B2\|SNT3\|SNTL
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SNTB2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.00503	2.74e-03
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	0.293165	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.251991	1.54e-10

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Expression of SNTB2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SNTB2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SNTB2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SNTB2	hsa-miR-4291	99.1733	NM_006750
SNTB2	hsa-miR-124-3p	98.435	NM_006750
SNTB2	hsa-miR-506-3p	98.435	NM_006750
SNTB2	hsa-miR-570-3p	97.2983	NM_006750
SNTB2	hsa-miR-4775	97.1985	NM_006750
SNTB2	hsa-miR-6134	96.0089	NM_006750
SNTB2	hsa-miR-579-3p	95.6663	NM_006750
SNTB2	hsa-miR-3613-3p	95.3192	NM_006750
SNTB2	hsa-miR-664b-3p	95.2295	NM_006750
SNTB2	hsa-miR-3911	94.952	NM_006750
SNTB2	hsa-miR-10523-5p	94.9367	NM_006750
SNTB2	hsa-miR-106b-5p	94.3841	NM_006750
SNTB2	hsa-miR-20a-5p	94.3841	NM_006750
SNTB2	hsa-miR-519d-3p	94.3192	NM_006750
SNTB2	hsa-miR-93-5p	94.3192	NM_006750
SNTB2	hsa-miR-106a-5p	94.3192	NM_006750
SNTB2	hsa-miR-20b-5p	94.3192	NM_006750
SNTB2	hsa-miR-17-5p	94.3192	NM_006750
SNTB2	hsa-miR-3180-5p	93.2614	NM_006750
SNTB2	hsa-miR-526b-3p	93.2095	NM_006750
SNTB2	hsa-miR-582-5p	92.9106	NM_006750
SNTB2	hsa-miR-548e-5p	92.4251	NM_006750
SNTB2	hsa-miR-5011-5p	92.1385	NM_006750
SNTB2	hsa-miR-208a-5p	91.9811	NM_006750
SNTB2	hsa-miR-208b-5p	91.9811	NM_006750
SNTB2	hsa-miR-3190-5p	91.2801	NM_006750
SNTB2	hsa-miR-371b-5p	90.81	NM_006750
SNTB2	hsa-miR-616-5p	90.81	NM_006750
SNTB2	hsa-miR-373-5p	90.81	NM_006750
SNTB2	hsa-miR-144-3p	90.4553	NM_006750
SNTB2	hsa-miR-4266	90.3708	NM_006750
SNTB2	hsa-miR-1273c	90.1749	NM_006750
SNTB2	hsa-miR-3646	89.9685	NM_006750
SNTB2	hsa-miR-6804-3p	89.8665	NM_006750
SNTB2	hsa-miR-203a-3p	89.7783	NM_006750
SNTB2	hsa-miR-218-5p	89.6121	NM_006750
SNTB2	hsa-miR-3680-3p	89.5296	NM_006750
SNTB2	hsa-miR-4762-3p	89.4451	NM_006750
SNTB2	hsa-miR-5582-5p	88.5411	NM_006750
SNTB2	hsa-miR-145-5p	88.4898	NM_006750
SNTB2	hsa-miR-5195-3p	88.4898	NM_006750
SNTB2	hsa-miR-4516	88.4322	NM_006750
SNTB2	hsa-miR-3119	88.1435	NM_006750
SNTB2	hsa-miR-30e-5p	87.3311	NM_006750
SNTB2	hsa-miR-30c-5p	87.3311	NM_006750
SNTB2	hsa-miR-30b-5p	87.3311	NM_006750
SNTB2	hsa-miR-30a-5p	87.3311	NM_006750
SNTB2	hsa-miR-30d-5p	87.3311	NM_006750
SNTB2	hsa-miR-449a	86.8846	NM_006750
SNTB2	hsa-miR-34a-5p	86.8846	NM_006750

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Motifs and transcription factors (TFs) regulating SNTB2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SNTB2	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
SNTB2	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
SNTB2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
SNTB2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
SNTB2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SNTB2	jaspar__MA0079.5	SP1 (directAnnotation).
SNTB2	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
SNTB2	transfac_pro__M01253	CNOT3 (directAnnotation).
SNTB2	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."