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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SNAP23

Summary for SNAP23

Gene information	Gene symbol	SNAP23
	Ensembl ID	ENSG00000092531
	Entrez ID	8773
	Gene name	synaptosome associated protein 23
	Synonyms	HsT17016\|SNAP23A\|SNAP23B
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SNAP23

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.752101	3.80e-05
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.362278	0.00e+00

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Expression of SNAP23 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SNAP23

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SNAP23

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SNAP23	hsa-miR-4775	97.848	NM_003825
SNAP23	hsa-miR-590-3p	97.5739	NM_003825
SNAP23	hsa-miR-146a-3p	94.6425	NM_003825
SNAP23	hsa-miR-4714-5p	93.9768	NM_003825
SNAP23	hsa-miR-150-5p	93.3675	NM_003825
SNAP23	hsa-miR-4729	92.5373	NM_003825
SNAP23	hsa-miR-4326	91.6371	NM_003825
SNAP23	hsa-miR-5571-5p	90.0424	NM_003825
SNAP23	hsa-miR-570-3p	88.3632	NM_003825
SNAP23	hsa-miR-4452	88.1056	NM_003825
SNAP23	hsa-miR-891b	87.0909	NM_003825
SNAP23	hsa-miR-466	86.7203	NM_003825
SNAP23	hsa-miR-34b-3p	86.1841	NM_003825
SNAP23	hsa-miR-4282	84.6404	NM_003825
SNAP23	hsa-miR-3646	84.0632	NM_003825
SNAP23	hsa-miR-1252-3p	84.0632	NM_003825
SNAP23	hsa-miR-4680-3p	84.0611	NM_003825
SNAP23	hsa-miR-1248	82.6766	NM_003825
SNAP23	hsa-miR-4713-5p	82.636	NM_003825
SNAP23	hsa-miR-519d-5p	82.0088	NM_003825
SNAP23	hsa-miR-302a-5p	80.3867	NM_003825

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Motifs and transcription factors (TFs) regulating SNAP23

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SNAP23	cisbp__M02645	ETS1 (directAnnotation).
SNAP23	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
SNAP23	taipale_tf_pairs__HOXB2_ELF1_SMGGAAGTMRTTA_CAP	ELF1; HOXB2 (directAnnotation).
SNAP23	metacluster_198.7	AHR; ZBTB14; ZBTB14; ZBTB14 (directAnnotation).
SNAP23	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."