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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: SMURF2

Summary for SMURF2

Gene informationGene symbol

SMURF2

Ensembl ID

ENSG00000108854

Entrez ID

64750

Gene nameSMAD specific E3 ubiquitin protein ligase 2
SynonymsNA
Gene typeprotein_coding
UniProtAcc

Q9HAU4


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Dataset with differentially expressed gene: SMURF2

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE175716

PDXTumor tissueLiver cancerAdvanced hepatocellular carcinomaTargeted therapysorafenibNAMalignant cells-0.6170220.00e+00

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Expression of SMURF2 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to SMURF2

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SMURF2

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
SMURF2hsa-miR-1468-3p98.9917NM_022739
SMURF2hsa-miR-469898.9269NM_022739
SMURF2hsa-miR-520e-5p98.5281NM_022739
SMURF2hsa-miR-449597.8163NM_022739
SMURF2hsa-miR-524-5p97.6463NM_022739
SMURF2hsa-miR-520d-5p97.6463NM_022739
SMURF2hsa-miR-676-3p97.2791NM_022739
SMURF2hsa-miR-431096.6326NM_022739
SMURF2hsa-miR-3121-3p96.4204NM_022739
SMURF2hsa-miR-7157-5p96.2705NM_022739
SMURF2hsa-miR-93-3p96.0297NM_022739
SMURF2hsa-miR-806394.7747NM_022739
SMURF2hsa-miR-9-5p94.1544NM_022739
SMURF2hsa-miR-56893.657NM_022739
SMURF2hsa-miR-7152-5p93.5924NM_022739
SMURF2hsa-miR-494-3p93.2977NM_022739
SMURF2hsa-miR-4666a-3p92.8386NM_022739
SMURF2hsa-miR-548aj-3p92.0642NM_022739
SMURF2hsa-miR-548x-3p92.0642NM_022739
SMURF2hsa-miR-364691.5053NM_022739
SMURF2hsa-miR-514a-5p91.3746NM_022739
SMURF2hsa-miR-64691.1354NM_022739
SMURF2hsa-miR-548bb-3p90.7867NM_022739
SMURF2hsa-miR-548ae-3p90.7867NM_022739
SMURF2hsa-miR-548ac90.7867NM_022739
SMURF2hsa-miR-548j-3p90.7867NM_022739
SMURF2hsa-miR-548d-3p90.7867NM_022739
SMURF2hsa-miR-548aq-3p90.7867NM_022739
SMURF2hsa-miR-548z90.7867NM_022739
SMURF2hsa-miR-548am-3p90.7867NM_022739
SMURF2hsa-miR-548ah-3p90.7867NM_022739
SMURF2hsa-miR-548h-3p90.7867NM_022739
SMURF2hsa-miR-659-3p90.7051NM_022739
SMURF2hsa-miR-4524b-5p90.596NM_022739
SMURF2hsa-miR-4524a-5p90.596NM_022739
SMURF2hsa-miR-4662a-5p89.2643NM_022739
SMURF2hsa-miR-96-3p88.4005NM_022739
SMURF2hsa-miR-569186.9801NM_022739
SMURF2hsa-miR-6805-3p86.9801NM_022739
SMURF2hsa-miR-117986.9349NM_022739
SMURF2hsa-miR-770286.7568NM_022739
SMURF2hsa-miR-122-3p86.6052NM_022739
SMURF2hsa-miR-548aw85.8691NM_022739
SMURF2hsa-miR-3074-5p85.5698NM_022739
SMURF2hsa-miR-57785.3072NM_022739
SMURF2hsa-miR-6826-3p85.0657NM_022739
SMURF2hsa-miR-299-5p85.0391NM_022739
SMURF2hsa-miR-548c-3p84.8715NM_022739
SMURF2hsa-miR-570084.2906NM_022739
SMURF2hsa-miR-6510-3p84.2184NM_022739
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Motifs and transcription factors (TFs) regulating SMURF2

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
SMURF2metacluster_135.11NR2C2 (directAnnotation).
SMURF2metacluster_135.10MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SMURF2metacluster_144.3ZNF704; ZNF704 (directAnnotation).
SMURF2metacluster_7.13ZFX (directAnnotation).
SMURF2kznf__ZNF730_Imbeault2017_RP_RCADEZNF730 (directAnnotation).
SMURF2cisbp__M00968MTF2 (directAnnotation).
SMURF2metacluster_155.23BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SMURF2metacluster_160.20JUND; PRDM15 (directAnnotation).
SMURF2cisbp__M00341PAX6 (directAnnotation).
SMURF2metacluster_198.3ZFP64 (directAnnotation).
SMURF2metacluster_141.5NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
SMURF2metacluster_151.1KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
SMURF2jaspar__MA0185.1DEAF1 (inferredBy_Orthology).
SMURF2metacluster_61.1DEAF1; DEAF1 (directAnnotation).
SMURF2cisbp__M00788ZFY (inferredBy_Orthology).
SMURF2kznf__ZNF213_Schmitges2016_RCADEZNF213 (directAnnotation).
SMURF2metacluster_175.1ZNF283 (directAnnotation).
SMURF2hdpi__ZNF304ZNF304 (directAnnotation).
SMURF2transfac_pro__M02844BCL6B (inferredBy_Orthology).
SMURF2metacluster_125.2TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
SMURF2metacluster_133.1ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SMURF2transfac_pro__M01199TRIM28 (directAnnotation).
SMURF2kznf__ZNF682_Isakova2017_SMiLE-seqZNF682 (directAnnotation).
SMURF2metacluster_151.2ZNF23 (directAnnotation).
SMURF2transfac_public__M00189TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SMURF2transfac_pro__M01219SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SMURF2transfac_pro__M03806ZBTB7C (directAnnotation).
SMURF2transfac_pro__M00915TFAP2A; TFAP2B; TFAP2C (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."