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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SMIM12

Summary for SMIM12

Gene information	Gene symbol	SMIM12
	Ensembl ID	ENSG00000163866
	Entrez ID	113444
	Gene name	small integral membrane protein 12
	Synonyms	C1orf212\|FLJ90372
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SMIM12

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	-0.3726	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.353723	1.90e-38
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.641689	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.379463	4.25e-27
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.460098	3.13e-24
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.524885	3.54e-42
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.365325	5.99e-15

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Expression of SMIM12 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SMIM12

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SMIM12

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SMIM12	hsa-miR-6733-5p	94.088	NM_001164824
SMIM12	hsa-miR-6739-5p	94.088	NM_001164824
SMIM12	hsa-miR-3153	93.747	NM_001164824
SMIM12	hsa-miR-597-3p	93.5475	NM_001164824
SMIM12	hsa-miR-1827	90.5701	NM_138428
SMIM12	hsa-miR-4668-5p	89.2681	NM_001164824
SMIM12	hsa-miR-3529-3p	89.0697	NM_138428
SMIM12	hsa-miR-7977	88.3857	NM_138428
SMIM12	hsa-miR-4667-3p	84.278	NM_138428
SMIM12	hsa-miR-3163	83.6864	NM_138428
SMIM12	hsa-miR-6515-3p	82.9618	NM_138428
SMIM12	hsa-miR-939-3p	82.2875	NM_001164824
SMIM12	hsa-miR-4276	81.8543	NM_138428
SMIM12	hsa-miR-3613-3p	81.5141	NM_138428
SMIM12	hsa-miR-182-3p	80.752	NM_001164824
SMIM12	hsa-miR-452-5p	80.7491	NM_138428
SMIM12	hsa-miR-4676-3p	80.7491	NM_138428
SMIM12	hsa-miR-892c-3p	80.7491	NM_138428

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Motifs and transcription factors (TFs) regulating SMIM12

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SMIM12	swissregulon__hs__ETV6	ETV6 (directAnnotation).
SMIM12	metacluster_33.5	MTF1 (inferredBy_Orthology).
SMIM12	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
SMIM12	metacluster_168.1	ZSCAN16 (directAnnotation).
SMIM12	transfac_pro__M05670	ZNF37A (directAnnotation).
SMIM12	taipale_tf_pairs__ERF_HOXA3_RSCGGAWNNNNNNNYMATTA_CAP_repr	ERF; HOXA3 (directAnnotation).
SMIM12	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
SMIM12	transfac_pro__M04826	EP300 (directAnnotation).
SMIM12	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
SMIM12	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
SMIM12	hdpi__ETV4	ETV4 (directAnnotation).
SMIM12	transfac_pro__M04748	GABPA (directAnnotation).
SMIM12	transfac_pro__M01182	HINFP (directAnnotation).
SMIM12	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
SMIM12	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
SMIM12	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
SMIM12	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
SMIM12	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
SMIM12	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
SMIM12	taipale_tf_pairs__GCM1_ELF1_NRCCCRNNCGGAAGNN_CAP_repr	ELF1; GCM1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."