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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SMIM10L1

Summary for SMIM10L1

Gene information	Gene symbol	SMIM10L1
	Ensembl ID	ENSG00000262986
	Entrez ID	100129361
	Gene name	small integral membrane protein 10 like 1
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P0DMW3

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Dataset with differentially expressed gene: SMIM10L1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.251688	2.67e-21
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.519177	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.359366	0.00e+00

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Expression of SMIM10L1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SMIM10L1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SMIM10L1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SMIM10L1	hsa-miR-5011-5p	97.9103	NM_001271592
SMIM10L1	hsa-miR-190a-3p	97.3101	NM_001271592
SMIM10L1	hsa-miR-6809-3p	90.7286	NM_001271592
SMIM10L1	hsa-miR-7702	88.9082	NM_001271592
SMIM10L1	hsa-miR-548d-3p	88.7097	NM_001271592
SMIM10L1	hsa-miR-548h-3p	88.7097	NM_001271592
SMIM10L1	hsa-miR-548ac	88.7097	NM_001271592
SMIM10L1	hsa-miR-548z	88.7097	NM_001271592
SMIM10L1	hsa-miR-548bb-3p	88.7097	NM_001271592
SMIM10L1	hsa-miR-1295b-5p	88.6734	NM_001271592
SMIM10L1	hsa-miR-4753-3p	88.1939	NM_001271592
SMIM10L1	hsa-miR-5187-5p	87.6288	NM_001271592
SMIM10L1	hsa-miR-1912-3p	87.5861	NM_001271592
SMIM10L1	hsa-miR-2052	87.377	NM_001271592
SMIM10L1	hsa-miR-942-3p	85.2876	NM_001271592
SMIM10L1	hsa-miR-3148	83.4511	NM_001271592
SMIM10L1	hsa-miR-1277-5p	83.0908	NM_001271592
SMIM10L1	hsa-miR-7152-5p	82.811	NM_001271592
SMIM10L1	hsa-miR-3074-5p	82.7094	NM_001271592
SMIM10L1	hsa-miR-5580-3p	82.4941	NM_001271592
SMIM10L1	hsa-miR-335-3p	82.2386	NM_001271592
SMIM10L1	hsa-miR-7161-5p	82.2133	NM_001271592
SMIM10L1	hsa-miR-8063	81.9491	NM_001271592
SMIM10L1	hsa-miR-181b-2-3p	81.5778	NM_001271592
SMIM10L1	hsa-miR-4420	81.5778	NM_001271592
SMIM10L1	hsa-miR-181b-3p	81.5778	NM_001271592

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Motifs and transcription factors (TFs) regulating SMIM10L1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SMIM10L1	metacluster_135.11	NR2C2 (directAnnotation).
SMIM10L1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SMIM10L1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
SMIM10L1	metacluster_198.3	ZFP64 (directAnnotation).
SMIM10L1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
SMIM10L1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SMIM10L1	metacluster_151.2	ZNF23 (directAnnotation).
SMIM10L1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
SMIM10L1	swissregulon__hs__ELF2	ELF2 (directAnnotation).
SMIM10L1	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
SMIM10L1	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
SMIM10L1	transfac_pro__M04748	GABPA (directAnnotation).
SMIM10L1	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."