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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SMARCC2

Summary for SMARCC2

Gene information	Gene symbol	SMARCC2
	Ensembl ID	ENSG00000139613
	Entrez ID	6601
	Gene name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2
	Synonyms	BAF170\|CRACC2\|Rsc8
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SMARCC2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.39468	3.49e-18
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.25619	0.00e+00

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Expression of SMARCC2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SMARCC2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SMARCC2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SMARCC2	hsa-miR-4723-3p	95.0163	NM_003075
SMARCC2	hsa-miR-6769b-3p	95.0163	NM_003075
SMARCC2	hsa-miR-3183	95.0163	NM_003075
SMARCC2	hsa-miR-6515-5p	93.6141	NM_003075
SMARCC2	hsa-miR-8085	92.3207	NM_003075
SMARCC2	hsa-miR-6731-5p	92.3207	NM_003075
SMARCC2	hsa-miR-373-3p	91.6642	NM_001130420
SMARCC2	hsa-miR-520c-3p	91.6642	NM_001130420
SMARCC2	hsa-miR-372-3p	91.6642	NM_001130420
SMARCC2	hsa-miR-520d-3p	91.6642	NM_001130420
SMARCC2	hsa-miR-520e-3p	91.6642	NM_001130420
SMARCC2	hsa-miR-520b-3p	91.6642	NM_001130420
SMARCC2	hsa-miR-520a-3p	91.6642	NM_001130420
SMARCC2	hsa-miR-3175	91.5899	NM_001130420
SMARCC2	hsa-miR-302b-3p	91.1829	NM_001130420
SMARCC2	hsa-miR-302c-3p	91.1829	NM_001130420
SMARCC2	hsa-miR-302a-3p	91.1829	NM_001130420
SMARCC2	hsa-miR-302d-3p	91.1829	NM_001130420
SMARCC2	hsa-miR-302e	91.1829	NM_001130420
SMARCC2	hsa-miR-6763-5p	90.3282	NM_001130420
SMARCC2	hsa-miR-3150a-3p	90.3282	NM_001130420
SMARCC2	hsa-miR-7111-5p	89.4963	NM_003075
SMARCC2	hsa-miR-6870-5p	89.4963	NM_003075
SMARCC2	hsa-miR-4723-5p	89.4963	NM_003075
SMARCC2	hsa-miR-5698	89.4963	NM_003075
SMARCC2	hsa-miR-5196-5p	89.3515	NM_001130420
SMARCC2	hsa-miR-4747-5p	89.3515	NM_001130420
SMARCC2	hsa-miR-3691-3p	87.8341	NM_003075
SMARCC2	hsa-miR-4475	86.5136	NM_001130420
SMARCC2	hsa-miR-6797-5p	86.3208	NM_003075
SMARCC2	hsa-miR-1249-5p	86.3208	NM_003075
SMARCC2	hsa-miR-92a-2-5p	85.8585	NM_003075
SMARCC2	hsa-miR-520f-3p	85.6864	NM_001130420
SMARCC2	hsa-miR-3124-3p	85.5809	NM_001130420
SMARCC2	hsa-miR-4680-5p	85.3309	NM_003075
SMARCC2	hsa-miR-6810-5p	83.8416	NM_003075
SMARCC2	hsa-miR-3928-3p	83.7346	NM_001130420
SMARCC2	hsa-miR-4721	80.8584	NM_003075
SMARCC2	hsa-miR-4495	80.3795	NM_001130420

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Motifs and transcription factors (TFs) regulating SMARCC2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SMARCC2	swissregulon__hs__ETV6	ETV6 (directAnnotation).
SMARCC2	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
SMARCC2	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
SMARCC2	transfac_pro__M04794	TAF1 (directAnnotation).
SMARCC2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
SMARCC2	jaspar__MA0748.2	YY2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."