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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SMARCC1

Summary for SMARCC1

Gene information	Gene symbol	SMARCC1
	Ensembl ID	ENSG00000173473
	Entrez ID	6599
	Gene name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
	Synonyms	BAF155\|CRACC1\|Rsc8\|SRG3
	Gene type	protein_coding
	UniProtAcc	Q92922

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Dataset with differentially expressed gene: SMARCC1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.345955	3.25e-16
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.439073	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.74857	3.96e-03
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.361042	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.56866	0.00e+00

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Expression of SMARCC1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SMARCC1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
SMARCC1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating SMARCC1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SMARCC1	hsa-miR-580-5p	93.4984	NM_003074
SMARCC1	hsa-miR-6854-5p	93.4908	NM_003074
SMARCC1	hsa-miR-9-3p	93.189	NM_003074
SMARCC1	hsa-miR-181b-3p	91.3705	NM_003074
SMARCC1	hsa-miR-4420	91.3705	NM_003074
SMARCC1	hsa-miR-181b-2-3p	91.3705	NM_003074
SMARCC1	hsa-miR-4533	91.1835	NM_003074
SMARCC1	hsa-miR-532-5p	91.1115	NM_003074
SMARCC1	hsa-miR-1-3p	90.8064	NM_003074
SMARCC1	hsa-miR-206	90.8064	NM_003074
SMARCC1	hsa-miR-548ap-3p	90.3922	NM_003074
SMARCC1	hsa-miR-548aa	90.3922	NM_003074
SMARCC1	hsa-miR-548t-3p	90.3922	NM_003074
SMARCC1	hsa-miR-5196-5p	90.0013	NM_003074
SMARCC1	hsa-miR-4747-5p	90.0013	NM_003074
SMARCC1	hsa-miR-610	89.6753	NM_003074
SMARCC1	hsa-miR-4762-3p	89.2706	NM_003074
SMARCC1	hsa-let-7c-3p	88.579	NM_003074
SMARCC1	hsa-miR-659-3p	88.455	NM_003074
SMARCC1	hsa-miR-548an	88.0984	NM_003074
SMARCC1	hsa-miR-613	87.9883	NM_003074
SMARCC1	hsa-miR-3202	86.4979	NM_003074
SMARCC1	hsa-miR-657	86.2726	NM_003074
SMARCC1	hsa-miR-218-1-3p	85.9537	NM_003074
SMARCC1	hsa-miR-497-3p	85.2528	NM_003074
SMARCC1	hsa-miR-544b	84.7869	NM_003074
SMARCC1	hsa-miR-655-5p	84.5969	NM_003074
SMARCC1	hsa-miR-651-3p	84.5241	NM_003074
SMARCC1	hsa-miR-3928-3p	83.6449	NM_003074
SMARCC1	hsa-miR-644a	83.6219	NM_003074
SMARCC1	hsa-miR-770-5p	83.292	NM_003074
SMARCC1	hsa-miR-4712-5p	83.292	NM_003074
SMARCC1	hsa-miR-506-3p	82.5442	NM_003074
SMARCC1	hsa-miR-124-3p	82.5442	NM_003074
SMARCC1	hsa-miR-3674	81.9527	NM_003074
SMARCC1	hsa-miR-4500	81.3804	NM_003074
SMARCC1	hsa-miR-3619-5p	81.1774	NM_003074
SMARCC1	hsa-miR-4267	80.7722	NM_003074
SMARCC1	hsa-miR-548p	80.6878	NM_003074
SMARCC1	hsa-miR-3915	80.5039	NM_003074
SMARCC1	hsa-miR-505-5p	80.436	NM_003074
SMARCC1	hsa-miR-488-3p	80.3812	NM_003074

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Motifs and transcription factors (TFs) regulating SMARCC1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SMARCC1	metacluster_7.13	ZFX (directAnnotation).
SMARCC1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
SMARCC1	metacluster_151.2	ZNF23 (directAnnotation).
SMARCC1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
SMARCC1	transfac_pro__M05479	ZNF580 (directAnnotation).
SMARCC1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SMARCC1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
SMARCC1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SMARCC1	hdpi__ETV4	ETV4 (directAnnotation).
SMARCC1	transfac_pro__M06071	ZNF814 (directAnnotation).
SMARCC1	jaspar__MA0748.2	YY2 (directAnnotation).
SMARCC1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
SMARCC1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SMARCC1	jaspar__MA0079.5	SP1 (directAnnotation).
SMARCC1	transfac_pro__M04826	EP300 (directAnnotation).
SMARCC1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
SMARCC1	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
SMARCC1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
SMARCC1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
SMARCC1	transfac_pro__M01298	MECP2 (directAnnotation).
SMARCC1	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
SMARCC1	metacluster_182.10	ZFX (directAnnotation).
SMARCC1	transfac_pro__M00492	STAT1 (directAnnotation).
SMARCC1	transfac_pro__M06173	ZNF85 (directAnnotation).
SMARCC1	hdpi__FLI1	FLI1 (directAnnotation).
SMARCC1	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
SMARCC1	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
SMARCC1	taipale_tf_pairs__ETV5_FOXI1_TGTTGNCGGAWRN_CAP	ETV5; FOXI1 (directAnnotation).
SMARCC1	swissregulon__hs__GMEB2	GMEB2 (directAnnotation).
SMARCC1	transfac_pro__M02089	E2F3 (directAnnotation).
SMARCC1	transfac_pro__M02898	SMAD3 (directAnnotation).
SMARCC1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
SMARCC1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
SMARCC1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
SMARCC1	hdpi__HIP2	UBE2K (directAnnotation).
SMARCC1	hdpi__NRL	NRL (directAnnotation).
SMARCC1	transfac_pro__M00430	E2F1 (directAnnotation).
SMARCC1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
SMARCC1	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
SMARCC1	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
SMARCC1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SMARCC1	cisbp__M07938	E2F1 (directAnnotation).
SMARCC1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
SMARCC1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
SMARCC1	transfac_pro__M07436	WT1 (directAnnotation).
SMARCC1	metacluster_3.14	WT1; WT1 (directAnnotation).
SMARCC1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
SMARCC1	transfac_pro__M01837	KLF11 (directAnnotation).
SMARCC1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
SMARCC1	transfac_pro__M07310	SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."