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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: SMARCA5

Summary for SMARCA5

Gene information	Gene symbol	SMARCA5
	Ensembl ID	ENSG00000153147
	Entrez ID	8467
	Gene name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
	Synonyms	hISWI\|hSNF2H\|ISWI
	Gene type	protein_coding
	UniProtAcc	O60264

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Dataset with differentially expressed gene: SMARCA5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.472566	5.59e-37
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Plasma cells	-0.260687	1.39e-06
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.250523	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.300309	2.13e-11
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.376196	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.250278	3.97e-35
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.437026	3.01e-31

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Expression of SMARCA5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SMARCA5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SMARCA5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SMARCA5	hsa-miR-98-3p	99.2991	NM_003601
SMARCA5	hsa-let-7b-3p	99.2991	NM_003601
SMARCA5	hsa-let-7f-1-3p	99.2991	NM_003601
SMARCA5	hsa-let-7a-3p	99.2991	NM_003601
SMARCA5	hsa-miR-548at-5p	98.535	NM_003601
SMARCA5	hsa-miR-4729	98.4983	NM_003601
SMARCA5	hsa-miR-6513-3p	98.3893	NM_003601
SMARCA5	hsa-miR-606	97.5549	NM_003601
SMARCA5	hsa-miR-5696	96.3825	NM_003601
SMARCA5	hsa-miR-569	95.9031	NM_003601
SMARCA5	hsa-miR-548ah-5p	95.0043	NM_003601
SMARCA5	hsa-miR-3609	94.7642	NM_003601
SMARCA5	hsa-miR-6844	94.0112	NM_003601
SMARCA5	hsa-miR-99a-5p	93.9611	NM_003601
SMARCA5	hsa-miR-100-5p	93.9611	NM_003601
SMARCA5	hsa-miR-99b-5p	93.9611	NM_003601
SMARCA5	hsa-miR-4282	93.7445	NM_003601
SMARCA5	hsa-miR-101-3p	93.0502	NM_003601
SMARCA5	hsa-miR-4719	92.0194	NM_003601
SMARCA5	hsa-miR-8062	91.9667	NM_003601
SMARCA5	hsa-miR-3180-5p	91.952	NM_003601
SMARCA5	hsa-miR-548t-5p	91.6797	NM_003601
SMARCA5	hsa-miR-548az-5p	91.6797	NM_003601
SMARCA5	hsa-miR-335-3p	91.2796	NM_003601
SMARCA5	hsa-miR-4291	90.3394	NM_003601
SMARCA5	hsa-miR-3606-5p	89.8963	NM_003601
SMARCA5	hsa-miR-511-5p	89.2212	NM_003601
SMARCA5	hsa-miR-29b-1-5p	88.2178	NM_003601
SMARCA5	hsa-miR-3163	88.2145	NM_003601
SMARCA5	hsa-miR-367-5p	87.8697	NM_003601
SMARCA5	hsa-miR-921	87.758	NM_003601
SMARCA5	hsa-miR-551b-5p	87.2193	NM_003601
SMARCA5	hsa-miR-4789-5p	87.1748	NM_003601
SMARCA5	hsa-miR-548aj-3p	87.0443	NM_003601
SMARCA5	hsa-miR-548x-3p	87.0443	NM_003601
SMARCA5	hsa-miR-4666a-3p	85.7543	NM_003601
SMARCA5	hsa-miR-561-3p	85.3387	NM_003601
SMARCA5	hsa-miR-33a-5p	84.922	NM_003601
SMARCA5	hsa-miR-33b-5p	84.922	NM_003601
SMARCA5	hsa-miR-4443	84.7101	NM_003601
SMARCA5	hsa-miR-3925-3p	84.6043	NM_003601
SMARCA5	hsa-miR-3646	84.5517	NM_003601
SMARCA5	hsa-miR-6892-5p	84.4685	NM_003601
SMARCA5	hsa-miR-6762-3p	84.3241	NM_003601
SMARCA5	hsa-miR-548aq-3p	82.9992	NM_003601
SMARCA5	hsa-miR-548am-3p	82.9992	NM_003601
SMARCA5	hsa-miR-548ae-3p	82.9992	NM_003601
SMARCA5	hsa-miR-548ah-3p	82.9992	NM_003601
SMARCA5	hsa-miR-548j-3p	82.9992	NM_003601
SMARCA5	hsa-miR-4475	82.8294	NM_003601

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Motifs and transcription factors (TFs) regulating SMARCA5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SMARCA5	metacluster_7.13	ZFX (directAnnotation).
SMARCA5	cisbp__M01863	ZNF711 (inferredBy_Orthology).
SMARCA5	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
SMARCA5	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
SMARCA5	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SMARCA5	hdpi__ETV4	ETV4 (directAnnotation).
SMARCA5	transfac_pro__M06071	ZNF814 (directAnnotation).
SMARCA5	jaspar__MA0079.5	SP1 (directAnnotation).
SMARCA5	cisbp__M00968	MTF2 (directAnnotation).
SMARCA5	metacluster_160.20	JUND; PRDM15 (directAnnotation).
SMARCA5	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
SMARCA5	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
SMARCA5	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
SMARCA5	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
SMARCA5	cisbp__M00788	ZFY (inferredBy_Orthology).
SMARCA5	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SMARCA5	metacluster_175.1	ZNF283 (directAnnotation).
SMARCA5	hdpi__ZNF304	ZNF304 (directAnnotation).
SMARCA5	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
SMARCA5	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
SMARCA5	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SMARCA5	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
SMARCA5	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SMARCA5	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SMARCA5	transfac_pro__M03806	ZBTB7C (directAnnotation).
SMARCA5	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SMARCA5	transfac_pro__M04826	EP300 (directAnnotation).
SMARCA5	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
SMARCA5	metacluster_141.2	E2F2; E2F3 (directAnnotation).
SMARCA5	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
SMARCA5	transfac_pro__M04862	NRF1 (directAnnotation).
SMARCA5	jaspar__MA0748.2	YY2 (directAnnotation).
SMARCA5	taipale_tf_pairs__MYBL1_EOMES_RSGTGNNNAACGK_CAP_repr	EOMES; MYBL1 (directAnnotation).
SMARCA5	cisbp__M02645	ETS1 (directAnnotation).
SMARCA5	taipale_tf_pairs__GCM2_SOX15_ATRCGGGYNNNNNYWTTGTNN_CAP_repr	GCM2; SOX15 (directAnnotation).
SMARCA5	metacluster_58.2	SOX10; SOX9; SOX9 (directAnnotation).
SMARCA5	taipale_cyt_meth__CDX2_NRTCGTAAANNN_eDBD_meth	CDX2 (directAnnotation).
SMARCA5	transfac_pro__M06267	ZNF805 (directAnnotation).
SMARCA5	metacluster_141.9	TAF1; YY1; YY1 (directAnnotation).
SMARCA5	metacluster_45.6	E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F4; E2F4 (directAnnotation). E2F2; E2F3 (inferredBy_Orthology).
SMARCA5	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
SMARCA5	jaspar__MA1154.1	ZNF282 (directAnnotation).
SMARCA5	transfac_pro__M06055	ZNF99 (directAnnotation).
SMARCA5	metacluster_164.2	HMBOX1 (directAnnotation).
SMARCA5	metacluster_168.16	FOXG1 (inferredBy_Orthology).
SMARCA5	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
SMARCA5	hdpi__NRL	NRL (directAnnotation).
SMARCA5	transfac_pro__M07310	SP5 (directAnnotation).
SMARCA5	cisbp__M07938	E2F1 (directAnnotation).
SMARCA5	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
SMARCA5	"4-Deoxy-Alpha-D-Glucose"	DB02670	small molecule
SMARCA5	"Beta-D-Glucose"	DB02379	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."