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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SMARCA2

Summary for SMARCA2

Gene information	Gene symbol	SMARCA2
	Ensembl ID	ENSG00000080503
	Entrez ID	6595
	Gene name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
	Synonyms	BAF190\|BRM\|hBRM\|hSNF2a\|SNF2\|SNF2L2\|SNF2LA\|Sth1p\|SWI2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SMARCA2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	pDCs	0.398188	5.47e-03
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.281338	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.260442	8.12e-03
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.32696	2.31e-43

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Expression of SMARCA2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SMARCA2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SMARCA2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SMARCA2	hsa-miR-5587-5p	96.4785	NM_001289396
SMARCA2	hsa-miR-6867-5p	96.0706	NM_001289398
SMARCA2	hsa-miR-5100	95.293	NM_001289398
SMARCA2	hsa-miR-5008-5p	95.0061	NM_001289396
SMARCA2	hsa-miR-6815-3p	93.5977	NM_001289396
SMARCA2	hsa-miR-144-5p	92.9866	NM_001289396
SMARCA2	hsa-miR-19a-3p	91.734	NM_001289398
SMARCA2	hsa-miR-19b-3p	91.734	NM_001289398
SMARCA2	hsa-miR-4694-3p	91.4279	NM_001289398
SMARCA2	hsa-miR-3162-5p	90.7756	NM_001289398
SMARCA2	hsa-miR-128-3p	89.7551	NM_001289396
SMARCA2	hsa-miR-216a-3p	89.7551	NM_001289396
SMARCA2	hsa-miR-3681-3p	89.7551	NM_001289396
SMARCA2	hsa-miR-6825-5p	89.416	NM_001289398
SMARCA2	hsa-miR-3152-5p	89.0388	NM_001289396
SMARCA2	hsa-miR-3148	88.7821	NM_001289398
SMARCA2	hsa-miR-187-5p	88.7749	NM_001289396
SMARCA2	hsa-miR-520d-5p	88.6429	NM_001289396
SMARCA2	hsa-miR-524-5p	88.6429	NM_001289396
SMARCA2	hsa-miR-3662	88.0813	NM_001289396
SMARCA2	hsa-miR-3688-3p	87.6612	NM_001289398
SMARCA2	hsa-miR-133b	87.4273	NM_001289396
SMARCA2	hsa-miR-133a-3p	87.4273	NM_001289396
SMARCA2	hsa-miR-335-5p	86.8576	NM_001289398
SMARCA2	hsa-miR-5680	86.5729	NM_001289396
SMARCA2	hsa-miR-1288-5p	86.4662	NM_001289398
SMARCA2	hsa-miR-140-3p	85.616	NM_001289396
SMARCA2	hsa-miR-3613-3p	84.2398	NM_001289398
SMARCA2	hsa-miR-6089	83.899	NM_001289396
SMARCA2	hsa-miR-3132	83.8081	NM_001289398
SMARCA2	hsa-miR-4680-5p	82.5651	NM_001289396
SMARCA2	hsa-miR-7-2-3p	82.4573	NM_001289396
SMARCA2	hsa-miR-7-1-3p	82.4573	NM_001289396
SMARCA2	hsa-miR-197-5p	81.3875	NM_001289398
SMARCA2	hsa-miR-6861-5p	80.4335	NM_001289396
SMARCA2	hsa-miR-208a-5p	80.2235	NM_001289398
SMARCA2	hsa-miR-208b-5p	80.2235	NM_001289398
SMARCA2	hsa-miR-4277	80.1988	NM_001289396
SMARCA2	hsa-miR-98-3p	80.0151	NM_001289398
SMARCA2	hsa-let-7f-1-3p	80.0151	NM_001289398
SMARCA2	hsa-let-7a-3p	80.0151	NM_001289398
SMARCA2	hsa-let-7b-3p	80.0151	NM_001289398

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Motifs and transcription factors (TFs) regulating SMARCA2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SMARCA2	jaspar__MA0748.2	YY2 (directAnnotation).
SMARCA2	cisbp__M00788	ZFY (inferredBy_Orthology).
SMARCA2	metacluster_7.13	ZFX (directAnnotation).
SMARCA2	taipale_tf_pairs__ERF_PITX1_NSCGGANNNNNNGGMTTA_CAP	ERF; PITX1 (directAnnotation).
SMARCA2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SMARCA2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
SMARCA2	hdpi__HIP2	UBE2K (directAnnotation).
SMARCA2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
SMARCA2	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
SMARCA2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SMARCA2	transfac_pro__M02898	SMAD3 (directAnnotation).
SMARCA2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
SMARCA2	metacluster_191.5	SPDEF (inferredBy_Orthology).
SMARCA2	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
SMARCA2	transfac_pro__M04893	TAF1 (directAnnotation).
SMARCA2	cisbp__M00249	WT1 (directAnnotation).
SMARCA2	transfac_pro__M00430	E2F1 (directAnnotation).
SMARCA2	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
SMARCA2	hdpi__ZNF304	ZNF304 (directAnnotation).
SMARCA2	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
SMARCA2	transfac_pro__M00938	E2F1 (directAnnotation).
SMARCA2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SMARCA2	metacluster_198.3	ZFP64 (directAnnotation).
SMARCA2	cisbp__M00341	PAX6 (directAnnotation).
SMARCA2	cisbp__M00968	MTF2 (directAnnotation).
SMARCA2	transfac_pro__M00716	ZBTB14 (directAnnotation).
SMARCA2	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
SMARCA2	transfac_pro__M04916	TAF1 (directAnnotation).
SMARCA2	transfac_pro__M02089	E2F3 (directAnnotation).
SMARCA2	transfac_pro__M04817	ZBTB33 (directAnnotation).
SMARCA2	transfac_pro__M07310	SP5 (directAnnotation).
SMARCA2	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
SMARCA2	hdpi__NRL	NRL (directAnnotation).
SMARCA2	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
SMARCA2	transfac_pro__M07387	ZBTB7A (directAnnotation).
SMARCA2	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
SMARCA2	transfac_pro__M01783	SP2 (directAnnotation).
SMARCA2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
SMARCA2	cisbp__M07938	E2F1 (directAnnotation).
SMARCA2	tfdimers__MD00483	ZBTB14 (directAnnotation).
SMARCA2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SMARCA2	hdpi__GTF3C2	GTF3C2 (directAnnotation).
SMARCA2	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
SMARCA2	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
SMARCA2	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
SMARCA2	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
SMARCA2	transfac_pro__M03806	ZBTB7C (directAnnotation).
SMARCA2	metacluster_135.11	NR2C2 (directAnnotation).
SMARCA2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
SMARCA2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."