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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SMAD7

Summary for SMAD7

Gene information	Gene symbol	SMAD7
	Ensembl ID	ENSG00000101665
	Entrez ID	4092
	Gene name	SMAD family member 7
	Synonyms	MADH7\|MADH8
	Gene type	protein_coding
	UniProtAcc	O15105

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Dataset with differentially expressed gene: SMAD7

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.303439	4.60e-23

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Expression of SMAD7 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SMAD7

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
SMAD7	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating SMAD7

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SMAD7	hsa-miR-4524a-5p	96.7751	NM_001190821
SMAD7	hsa-miR-4524b-5p	96.7751	NM_001190821
SMAD7	hsa-miR-410-3p	96.4395	NM_005904
SMAD7	hsa-miR-627-3p	95.1418	NM_005904
SMAD7	hsa-miR-5680	94.8325	NM_001190821
SMAD7	hsa-miR-3926	94.7993	NM_005904
SMAD7	hsa-miR-5011-5p	93.8435	NM_005904
SMAD7	hsa-miR-424-3p	93.4471	NM_001190821
SMAD7	hsa-miR-4803	93.1318	NM_001190821
SMAD7	hsa-miR-122b-3p	91.8937	NM_001190821
SMAD7	hsa-miR-21-3p	91.8937	NM_001190821
SMAD7	hsa-miR-15b-5p	91.7945	NM_001190821
SMAD7	hsa-miR-195-5p	91.7945	NM_001190821
SMAD7	hsa-miR-15a-5p	91.7945	NM_001190821
SMAD7	hsa-miR-16-5p	91.7945	NM_001190821
SMAD7	hsa-miR-497-5p	91.2055	NM_001190821
SMAD7	hsa-miR-424-5p	91.2055	NM_001190821
SMAD7	hsa-miR-6838-5p	91.2055	NM_001190821
SMAD7	hsa-miR-766-5p	90.2021	NM_005904
SMAD7	hsa-miR-1913	89.4025	NM_005904
SMAD7	hsa-miR-374b-3p	88.9059	NM_001190821
SMAD7	hsa-miR-581	88.8984	NM_005904
SMAD7	hsa-miR-1277-5p	87.6508	NM_005904
SMAD7	hsa-miR-4789-5p	87.0497	NM_005904
SMAD7	hsa-miR-190a-3p	86.3986	NM_005904
SMAD7	hsa-miR-5692a	85.5053	NM_001190821
SMAD7	hsa-miR-6083	85.1739	NM_005904
SMAD7	hsa-miR-6853-3p	84.3028	NM_005904
SMAD7	hsa-miR-665	83.3767	NM_001190821
SMAD7	hsa-miR-503-5p	83.2213	NM_001190821
SMAD7	hsa-miR-4729	83.0763	NM_001190821
SMAD7	hsa-miR-3680-3p	82.944	NM_005904
SMAD7	hsa-miR-4663	82.3834	NM_001190821
SMAD7	hsa-miR-21-5p	81.6395	NM_005904
SMAD7	hsa-miR-1263	81.3095	NM_001190821
SMAD7	hsa-miR-590-5p	81.2502	NM_005904
SMAD7	hsa-miR-487a-3p	81.2176	NM_005904
SMAD7	hsa-miR-154-3p	81.2176	NM_005904
SMAD7	hsa-miR-3973	80.8876	NM_001190821
SMAD7	hsa-miR-5692b	80.5003	NM_005904
SMAD7	hsa-miR-5692c	80.5003	NM_005904

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Motifs and transcription factors (TFs) regulating SMAD7

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SMAD7	transfac_pro__M01253	CNOT3 (directAnnotation).
SMAD7	transfac_pro__M04817	ZBTB33 (directAnnotation).
SMAD7	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."