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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SMAD1

Summary for SMAD1

Gene information	Gene symbol	SMAD1
	Ensembl ID	ENSG00000170365
	Entrez ID	4086
	Gene name	SMAD family member 1
	Synonyms	JV4-1\|MADH1\|MADR1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SMAD1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.60928	6.59e-09
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.254498	2.19e-04

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Expression of SMAD1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SMAD1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SMAD1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SMAD1	hsa-miR-1297	98.038	NM_001003688
SMAD1	hsa-miR-548as-3p	97.5157	NM_001003688
SMAD1	hsa-miR-4680-3p	97.4856	NM_001003688
SMAD1	hsa-miR-5697	97.4293	NM_001003688
SMAD1	hsa-miR-3613-3p	97.19	NM_001003688
SMAD1	hsa-miR-26a-5p	97.1531	NM_001003688
SMAD1	hsa-miR-26b-5p	97.1531	NM_001003688
SMAD1	hsa-miR-4465	96.8247	NM_001003688
SMAD1	hsa-miR-5587-5p	95.0949	NM_001003688
SMAD1	hsa-miR-216b-5p	94.8471	NM_001003688
SMAD1	hsa-miR-30b-5p	94.8358	NM_001003688
SMAD1	hsa-miR-30d-5p	94.8358	NM_001003688
SMAD1	hsa-miR-30a-5p	94.8358	NM_001003688
SMAD1	hsa-miR-30e-5p	94.8358	NM_001003688
SMAD1	hsa-miR-30c-5p	94.8358	NM_001003688
SMAD1	hsa-miR-510-3p	94.6112	NM_001003688
SMAD1	hsa-miR-6505-5p	94.4505	NM_001003688
SMAD1	hsa-miR-182-5p	94.1029	NM_001003688
SMAD1	hsa-miR-582-3p	93.4905	NM_001003688
SMAD1	hsa-miR-3120-3p	92.6736	NM_001003688
SMAD1	hsa-miR-548n	92.1945	NM_001003688
SMAD1	hsa-miR-3973	91.788	NM_001003688
SMAD1	hsa-miR-4282	91.3976	NM_001003688
SMAD1	hsa-miR-4691-5p	91.3635	NM_001003688
SMAD1	hsa-miR-6792-3p	91.3635	NM_001003688
SMAD1	hsa-miR-5689	91.2744	NM_001003688
SMAD1	hsa-miR-203a-3p	90.2956	NM_001003688
SMAD1	hsa-miR-520f-5p	90.2635	NM_001003688
SMAD1	hsa-miR-3660	90.1239	NM_001003688
SMAD1	hsa-miR-4526	90.1239	NM_001003688
SMAD1	hsa-miR-6806-5p	88.98	NM_001003688
SMAD1	hsa-miR-545-3p	88.9327	NM_001003688
SMAD1	hsa-miR-6838-3p	88.2449	NM_001003688
SMAD1	hsa-miR-6165	87.7859	NM_001003688
SMAD1	hsa-miR-205-5p	87.3599	NM_001003688
SMAD1	hsa-miR-96-5p	86.234	NM_001003688
SMAD1	hsa-miR-3942-5p	86.142	NM_001003688
SMAD1	hsa-miR-4703-5p	86.142	NM_001003688
SMAD1	hsa-miR-12122	86.1308	NM_001003688
SMAD1	hsa-miR-6893-3p	85.7415	NM_001003688
SMAD1	hsa-miR-370-3p	85.7415	NM_001003688
SMAD1	hsa-miR-12133	85.7401	NM_001003688
SMAD1	hsa-miR-1271-5p	85.7401	NM_001003688
SMAD1	hsa-miR-1252-5p	84.9219	NM_001003688
SMAD1	hsa-miR-494-3p	83.0142	NM_001003688
SMAD1	hsa-miR-3675-3p	82.7006	NM_001003688
SMAD1	hsa-miR-12136	82.4516	NM_001003688
SMAD1	hsa-miR-4709-5p	80.8879	NM_001003688
SMAD1	hsa-miR-4646-3p	80.6753	NM_001003688
SMAD1	hsa-miR-223-3p	80.3136	NM_001003688

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Motifs and transcription factors (TFs) regulating SMAD1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SMAD1	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
SMAD1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
SMAD1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
SMAD1	transfac_pro__M04617	ZBTB7A (directAnnotation).
SMAD1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
SMAD1	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
SMAD1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
SMAD1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
SMAD1	transfac_pro__M07387	ZBTB7A (directAnnotation).
SMAD1	transfac_pro__M07436	WT1 (directAnnotation).
SMAD1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
SMAD1	transfac_pro__M00716	ZBTB14 (directAnnotation).
SMAD1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
SMAD1	hdpi__HIP2	UBE2K (directAnnotation).
SMAD1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
SMAD1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
SMAD1	transfac_pro__M04893	TAF1 (directAnnotation).
SMAD1	transfac_pro__M03876	ZBTB33 (directAnnotation).
SMAD1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
SMAD1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SMAD1	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
SMAD1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SMAD1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
SMAD1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
SMAD1	metacluster_3.10	KLF2; KLF4 (directAnnotation).
SMAD1	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
SMAD1	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
SMAD1	transfac_pro__M01783	SP2 (directAnnotation).
SMAD1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
SMAD1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SMAD1	cisbp__M00341	PAX6 (directAnnotation).
SMAD1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
SMAD1	transfac_pro__M01253	CNOT3 (directAnnotation).
SMAD1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
SMAD1	metacluster_7.13	ZFX (directAnnotation).
SMAD1	cisbp__M00968	MTF2 (directAnnotation).
SMAD1	transfac_pro__M04817	ZBTB33 (directAnnotation).
SMAD1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
SMAD1	transfac_pro__M02089	E2F3 (directAnnotation).
SMAD1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
SMAD1	jaspar__MA0748.2	YY2 (directAnnotation).
SMAD1	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
SMAD1	taipale_tf_pairs__ERF_PITX1_NSCGGANNNNNNGGMTTA_CAP	ERF; PITX1 (directAnnotation).
SMAD1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."