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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SLITRK4

Summary for SLITRK4

Gene information	Gene symbol	SLITRK4
	Ensembl ID	ENSG00000179542
	Entrez ID	139065
	Gene name	SLIT and NTRK like family member 4
	Synonyms	DKFZp547M2010
	Gene type	protein_coding
	UniProtAcc	Q8IW52

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Dataset with differentially expressed gene: SLITRK4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-3.53638	2.34e-06

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Expression of SLITRK4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SLITRK4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SLITRK4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SLITRK4	hsa-miR-5011-5p	99.9815	NM_001184749
SLITRK4	hsa-miR-5692a	99.9189	NM_001184749
SLITRK4	hsa-miR-190a-3p	99.7624	NM_001184749
SLITRK4	hsa-miR-3924	99.1166	NM_001184749
SLITRK4	hsa-miR-8485	99.0713	NM_001184749
SLITRK4	hsa-miR-6873-3p	98.7088	NM_001184749
SLITRK4	hsa-miR-664a-3p	98.4116	NM_001184749
SLITRK4	hsa-miR-520d-5p	98.074	NM_001184749
SLITRK4	hsa-miR-524-5p	98.074	NM_001184749
SLITRK4	hsa-miR-5003-3p	97.7153	NM_001184749
SLITRK4	hsa-miR-329-5p	96.9941	NM_001184749
SLITRK4	hsa-miR-3941	96.9764	NM_001184749
SLITRK4	hsa-miR-4328	96.7963	NM_001184749
SLITRK4	hsa-miR-337-3p	96.6325	NM_001184749
SLITRK4	hsa-miR-3618	96.1984	NM_001184749
SLITRK4	hsa-miR-4310	95.3039	NM_001184749
SLITRK4	hsa-miR-603	95.2954	NM_001184749
SLITRK4	hsa-miR-5002-5p	95.243	NM_001184749
SLITRK4	hsa-miR-202-5p	94.596	NM_001184749
SLITRK4	hsa-miR-7-2-3p	94.4982	NM_001184749
SLITRK4	hsa-miR-182-5p	94.0212	NM_001184749
SLITRK4	hsa-miR-302c-5p	94.0026	NM_001184749
SLITRK4	hsa-miR-7-1-3p	93.952	NM_001184749
SLITRK4	hsa-miR-8062	93.7581	NM_001184749
SLITRK4	hsa-miR-4762-3p	93.5336	NM_001184749
SLITRK4	hsa-miR-4772-5p	93.5233	NM_001184749
SLITRK4	hsa-miR-6852-3p	93.2439	NM_001184749
SLITRK4	hsa-miR-7157-5p	92.982	NM_001184749
SLITRK4	hsa-miR-340-5p	92.5964	NM_001184749
SLITRK4	hsa-miR-3909	92.5436	NM_001184749
SLITRK4	hsa-miR-507	92.5317	NM_001184749
SLITRK4	hsa-miR-16-1-3p	92.2036	NM_001184749
SLITRK4	hsa-miR-3680-3p	92.1668	NM_001184749
SLITRK4	hsa-miR-124-3p	91.8893	NM_001184749
SLITRK4	hsa-miR-506-3p	91.8893	NM_001184749
SLITRK4	hsa-miR-557	91.8804	NM_001184749
SLITRK4	hsa-miR-548aw	91.7153	NM_001184749
SLITRK4	hsa-miR-374b-3p	91.5136	NM_001184749
SLITRK4	hsa-miR-144-3p	91.3377	NM_001184749
SLITRK4	hsa-miR-4652-3p	91.1728	NM_001184749
SLITRK4	hsa-miR-3065-5p	91.1173	NM_001184749
SLITRK4	hsa-miR-4422	91.0206	NM_001184749
SLITRK4	hsa-miR-548e-5p	90.9221	NM_001184749
SLITRK4	hsa-miR-561-3p	90.8912	NM_001184749
SLITRK4	hsa-miR-4743-3p	90.2583	NM_001184749
SLITRK4	hsa-miR-153-5p	90.1007	NM_001184749
SLITRK4	hsa-miR-19a-5p	89.7076	NM_001184749
SLITRK4	hsa-miR-19b-1-5p	89.7076	NM_001184749
SLITRK4	hsa-miR-19b-2-5p	89.7076	NM_001184749
SLITRK4	hsa-miR-7852-3p	89.6164	NM_001184749

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Motifs and transcription factors (TFs) regulating SLITRK4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."