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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SLC9A3R2

Summary for SLC9A3R2

Gene information	Gene symbol	SLC9A3R2
	Ensembl ID	ENSG00000065054
	Entrez ID	9351
	Gene name	SLC9A3 regulator 2
	Synonyms	E3KARP\|NHERF-2\|SIP-1\|TKA-1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SLC9A3R2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.50148	0.00e+00
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.406371	0.00e+00

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Expression of SLC9A3R2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SLC9A3R2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SLC9A3R2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SLC9A3R2	hsa-miR-7110-3p	99.9923	NM_001130012
SLC9A3R2	hsa-miR-6873-3p	97.6536	NM_001130012
SLC9A3R2	hsa-miR-149-3p	94.2477	NM_001130012
SLC9A3R2	hsa-miR-3678-3p	93.9276	NM_001130012
SLC9A3R2	hsa-miR-6825-5p	92.753	NM_001130012
SLC9A3R2	hsa-miR-6817-3p	91.7485	NM_001130012
SLC9A3R2	hsa-miR-939-5p	91.3738	NM_001130012
SLC9A3R2	hsa-miR-1343-5p	91.3738	NM_001130012
SLC9A3R2	hsa-miR-6870-5p	90.9198	NM_001130012
SLC9A3R2	hsa-miR-6764-3p	89.5702	NM_001130012
SLC9A3R2	hsa-miR-6824-3p	89.5702	NM_001130012
SLC9A3R2	hsa-miR-4728-5p	88.023	NM_001130012
SLC9A3R2	hsa-miR-6883-5p	88.023	NM_001130012
SLC9A3R2	hsa-miR-6785-5p	88.023	NM_001130012
SLC9A3R2	hsa-miR-4723-5p	85.6913	NM_001130012
SLC9A3R2	hsa-miR-7111-5p	85.6913	NM_001130012
SLC9A3R2	hsa-miR-5698	85.6913	NM_001130012
SLC9A3R2	hsa-miR-6814-5p	84.7015	NM_001130012
SLC9A3R2	hsa-miR-106a-3p	82.6091	NM_001130012
SLC9A3R2	hsa-miR-1207-5p	82.5964	NM_001130012
SLC9A3R2	hsa-miR-4763-3p	81.8943	NM_001130012

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Motifs and transcription factors (TFs) regulating SLC9A3R2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SLC9A3R2	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
SLC9A3R2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
SLC9A3R2	metacluster_137.2	ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
SLC9A3R2	metacluster_157.2	ATF3; ATF3; ATF3; BACH1; BACH1; BACH1; BACH2; BACH2; BACH2; BACH2; BATF; BATF; BCL11A; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; MAF; MAFB; MAFF; MAFG; MAFK; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2; NFE2L3; ZNF3; ZSCAN5C (directAnnotation). FOSL1; JUN; JUN; JUN; JUNB; JUNB; JUND (inferredBy_Orthology).
SLC9A3R2	metacluster_22.34	BACH2 (directAnnotation).
SLC9A3R2	metacluster_22.21	NFE2L2 (inferredBy_Orthology).
SLC9A3R2	metacluster_22.37	BACH1 (directAnnotation).
SLC9A3R2	metacluster_22.13	MAFK (inferredBy_Orthology).
SLC9A3R2	metacluster_22.18	BACH2 (inferredBy_Orthology).
SLC9A3R2	metacluster_171.4	TEAD1; TEAD1; TEAD1; TEAD1; TEAD3; TEAD3; TEAD4; TEAD4; TEAD4; TEAD4 (directAnnotation). TEAD1; TEAD2; TEAD4; TEAD4 (inferredBy_Orthology).
SLC9A3R2	metacluster_50.1	BATF; BATF; BATF; BATF; BNC2; FOS; FOSB; FOSL1; FOSL1; IRF4; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMAD2; SMAD3 (directAnnotation). BATF; BATF; BATF; FOS; FOSL1; FOSL2; JDP2; JUN; JUN; JUND (inferredBy_Orthology).
SLC9A3R2	metacluster_22.32	NFE2L2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."