Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: SLC7A8

Summary for SLC7A8

Gene information	Gene symbol	SLC7A8
	Ensembl ID	ENSG00000092068
	Entrez ID	23428
	Gene name	solute carrier family 7 member 8
	Synonyms	LAT2\|LPI-PC1
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: SLC7A8

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	5.58146	8.62e-11
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.270655	4.35e-05

Top

Expression of SLC7A8 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to SLC7A8

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating SLC7A8

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SLC7A8	hsa-miR-6825-5p	97.3027	NM_001267037
SLC7A8	hsa-miR-1207-5p	94.0898	NM_001267037
SLC7A8	hsa-miR-608	94.0062	NM_001267037
SLC7A8	hsa-miR-4651	93.9468	NM_001267037
SLC7A8	hsa-miR-3613-3p	93.7721	NM_001267036
SLC7A8	hsa-miR-766-5p	93.7138	NM_001267037
SLC7A8	hsa-miR-5698	93.6885	NM_001267037
SLC7A8	hsa-miR-4723-5p	93.6885	NM_001267037
SLC7A8	hsa-miR-6870-5p	93.6885	NM_001267037
SLC7A8	hsa-miR-7111-5p	93.6885	NM_001267037
SLC7A8	hsa-miR-4505	93.4333	NM_001267037
SLC7A8	hsa-miR-7106-5p	93.2171	NM_001267037
SLC7A8	hsa-miR-5787	92.8354	NM_001267037
SLC7A8	hsa-miR-4763-3p	92.5383	NM_001267037
SLC7A8	hsa-miR-6764-5p	92.0243	NM_001267037
SLC7A8	hsa-miR-1275	91.9135	NM_001267037
SLC7A8	hsa-miR-223-3p	91.1019	NM_001267037
SLC7A8	hsa-miR-6721-5p	90.1761	NM_001267036
SLC7A8	hsa-miR-5195-3p	90.1297	NM_001267036
SLC7A8	hsa-miR-145-5p	90.1297	NM_001267036
SLC7A8	hsa-miR-3910	90.0512	NM_001267036
SLC7A8	hsa-miR-4447	89.8743	NM_001267037
SLC7A8	hsa-miR-4747-5p	89.6742	NM_001267037
SLC7A8	hsa-miR-5196-5p	89.6742	NM_001267037
SLC7A8	hsa-miR-4668-3p	89.2979	NM_001267037
SLC7A8	hsa-miR-9-5p	88.9658	NM_001267036
SLC7A8	hsa-miR-6873-5p	88.884	NM_001267037
SLC7A8	hsa-miR-3192-5p	88.8521	NM_001267037
SLC7A8	hsa-miR-1915-3p	87.9747	NM_001267037
SLC7A8	hsa-miR-9851-3p	87.5256	NM_001267036
SLC7A8	hsa-miR-766-3p	86.4823	NM_001267036
SLC7A8	hsa-miR-6867-5p	85.595	NM_001267037
SLC7A8	hsa-miR-6511b-3p	85.0081	NM_001267037
SLC7A8	hsa-miR-6511a-3p	85.0081	NM_001267037
SLC7A8	hsa-miR-4665-5p	84.9814	NM_001267037
SLC7A8	hsa-miR-96-5p	84.5964	NM_001267036
SLC7A8	hsa-miR-1271-5p	83.1852	NM_001267036
SLC7A8	hsa-miR-12133	83.1852	NM_001267036
SLC7A8	hsa-miR-3714	82.8832	NM_001267036
SLC7A8	hsa-miR-1229-3p	81.5293	NM_001267037
SLC7A8	hsa-miR-593-5p	81.5063	NM_001267036
SLC7A8	hsa-miR-4728-5p	81.3478	NM_001267037
SLC7A8	hsa-miR-4472	81.1941	NM_001267037

Page: 1

Top

Motifs and transcription factors (TFs) regulating SLC7A8

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SLC7A8	hocomoco__OTX1_HUMAN.H11MO.0.D	OTX1 (directAnnotation).
SLC7A8	metacluster_102.2	ZBED1 (directAnnotation).
SLC7A8	transfac_pro__M04950	EGR1 (directAnnotation).
SLC7A8	metacluster_55.5	ZNF541 (directAnnotation).
SLC7A8	metacluster_30.4	BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
SLC7A8	"Alanine"	DB00160	small molecule
SLC7A8	"Phenylalanine"	DB00120	small molecule

Page: 1

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."