Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: SLC7A2

Summary for SLC7A2

Gene information	Gene symbol	SLC7A2
	Ensembl ID	ENSG00000003989
	Entrez ID	6542
	Gene name	solute carrier family 7 member 2
	Synonyms	ATRC2\|CAT-2\|HCAT2
	Gene type	protein_coding
	UniProtAcc	P52569

Top

Dataset with differentially expressed gene: SLC7A2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.391656	4.08e-02
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.530977	1.56e-40

Top

Expression of SLC7A2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to SLC7A2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating SLC7A2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SLC7A2	hsa-miR-4282	99.5451	NM_001008539
SLC7A2	hsa-miR-8485	94.5447	NM_001008539
SLC7A2	hsa-miR-3163	93.3794	NM_001008539
SLC7A2	hsa-miR-143-5p	92.0624	NM_001008539
SLC7A2	hsa-miR-12136	89.3591	NM_001008539
SLC7A2	hsa-miR-12123	87.9628	NM_001008539
SLC7A2	hsa-miR-3148	86.8107	NM_001008539
SLC7A2	hsa-miR-1-3p	86.5033	NM_001008539
SLC7A2	hsa-miR-206	86.5033	NM_001008539
SLC7A2	hsa-miR-513a-5p	86.1569	NM_001008539
SLC7A2	hsa-miR-5007-3p	85.8914	NM_001008539
SLC7A2	hsa-miR-3120-3p	84.5498	NM_001008539
SLC7A2	hsa-miR-376a-3p	83.4017	NM_001008539
SLC7A2	hsa-miR-376b-3p	83.4017	NM_001008539
SLC7A2	hsa-miR-613	82.9334	NM_001008539
SLC7A2	hsa-miR-1304-3p	82.8397	NM_001008539
SLC7A2	hsa-miR-548x-3p	82.4344	NM_001008539
SLC7A2	hsa-miR-548aj-3p	82.4344	NM_001008539
SLC7A2	hsa-miR-27b-3p	81.6613	NM_001008539
SLC7A2	hsa-miR-27a-3p	81.6613	NM_001008539
SLC7A2	hsa-miR-9985	81.6613	NM_001008539
SLC7A2	hsa-miR-548ae-3p	81.572	NM_001008539
SLC7A2	hsa-miR-548aq-3p	81.572	NM_001008539
SLC7A2	hsa-miR-651-3p	81.5517	NM_001008539

Page: 1

Top

Motifs and transcription factors (TFs) regulating SLC7A2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SLC7A2	metacluster_135.11	NR2C2 (directAnnotation).
SLC7A2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SLC7A2	tfdimers__MD00038	TFAP2C (directAnnotation).
SLC7A2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SLC7A2	metacluster_7.13	ZFX (directAnnotation).
SLC7A2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
SLC7A2	cisbp__M00968	MTF2 (directAnnotation).
SLC7A2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SLC7A2	metacluster_160.20	JUND; PRDM15 (directAnnotation).
SLC7A2	cisbp__M00341	PAX6 (directAnnotation).
SLC7A2	metacluster_198.3	ZFP64 (directAnnotation).
SLC7A2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
SLC7A2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
SLC7A2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
SLC7A2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
SLC7A2	cisbp__M00788	ZFY (inferredBy_Orthology).
SLC7A2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SLC7A2	metacluster_175.1	ZNF283 (directAnnotation).
SLC7A2	hdpi__ZNF304	ZNF304 (directAnnotation).
SLC7A2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
SLC7A2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
SLC7A2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SLC7A2	transfac_pro__M01199	TRIM28 (directAnnotation).
SLC7A2	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
SLC7A2	metacluster_151.2	ZNF23 (directAnnotation).
SLC7A2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SLC7A2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SLC7A2	transfac_pro__M03806	ZBTB7C (directAnnotation).
SLC7A2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
SLC7A2	"Lysine"	DB00123	small molecule
SLC7A2	"Ornithine"	DB00129	small molecule

Page: 1

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."