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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: SLC7A1

Summary for SLC7A1

Gene information	Gene symbol	SLC7A1
	Ensembl ID	ENSG00000139514
	Entrez ID	6541
	Gene name	solute carrier family 7 member 1
	Synonyms	ATRC1\|CAT-1\|ERR\|HCAT1\|REC1L
	Gene type	protein_coding
	UniProtAcc	P30825

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Dataset with differentially expressed gene: SLC7A1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.444459	5.96e-40
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.427784	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.272707	2.96e-08

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Expression of SLC7A1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SLC7A1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SLC7A1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SLC7A1	hsa-miR-6825-5p	96.6166	NM_003045
SLC7A1	hsa-miR-548p	96.2715	NM_003045
SLC7A1	hsa-miR-4731-5p	93.696	NM_003045
SLC7A1	hsa-miR-4319	93.5299	NM_003045
SLC7A1	hsa-miR-936	92.6578	NM_003045
SLC7A1	hsa-miR-125a-5p	92.4658	NM_003045
SLC7A1	hsa-miR-125b-5p	92.4658	NM_003045
SLC7A1	hsa-miR-647	91.1449	NM_003045
SLC7A1	hsa-miR-6785-5p	90.2184	NM_003045
SLC7A1	hsa-miR-4728-5p	90.2184	NM_003045
SLC7A1	hsa-miR-23c	89.3743	NM_003045
SLC7A1	hsa-miR-23b-3p	89.3743	NM_003045
SLC7A1	hsa-miR-23a-3p	89.3743	NM_003045
SLC7A1	hsa-miR-153-5p	89.0082	NM_003045
SLC7A1	hsa-miR-185-3p	89.0059	NM_003045
SLC7A1	hsa-miR-149-3p	88.782	NM_003045
SLC7A1	hsa-miR-6883-5p	88.782	NM_003045
SLC7A1	hsa-miR-222-5p	88.333	NM_003045
SLC7A1	hsa-miR-1207-5p	86.7459	NM_003045
SLC7A1	hsa-miR-4763-3p	86.1457	NM_003045
SLC7A1	hsa-miR-3613-3p	85.9829	NM_003045
SLC7A1	hsa-miR-3658	85.8604	NM_003045
SLC7A1	hsa-miR-140-3p	85.8399	NM_003045
SLC7A1	hsa-miR-6756-5p	85.3295	NM_003045
SLC7A1	hsa-miR-6766-5p	85.3295	NM_003045
SLC7A1	hsa-miR-122-5p	85.2274	NM_003045
SLC7A1	hsa-miR-4448	84.8619	NM_003045
SLC7A1	hsa-miR-604	84.4187	NM_003045
SLC7A1	hsa-miR-3918	84.2287	NM_003045
SLC7A1	hsa-miR-6759-5p	83.7745	NM_003045
SLC7A1	hsa-miR-4251	83.591	NM_003045
SLC7A1	hsa-miR-4505	83.5214	NM_003045
SLC7A1	hsa-miR-6829-5p	83.4455	NM_003045
SLC7A1	hsa-miR-4487	83.3599	NM_003045
SLC7A1	hsa-miR-3121-3p	83.2558	NM_003045
SLC7A1	hsa-miR-5787	83.003	NM_003045
SLC7A1	hsa-miR-4470	82.8371	NM_003045
SLC7A1	hsa-miR-4262	82.4998	NM_003045
SLC7A1	hsa-miR-4476	82.4089	NM_003045
SLC7A1	hsa-miR-6876-5p	82.4089	NM_003045
SLC7A1	hsa-miR-92a-2-5p	82.3938	NM_003045
SLC7A1	hsa-miR-124-3p	82.1752	NM_003045
SLC7A1	hsa-miR-506-3p	82.1752	NM_003045
SLC7A1	hsa-miR-942-5p	81.9976	NM_003045
SLC7A1	hsa-miR-559	81.8128	NM_003045
SLC7A1	hsa-miR-4455	81.6378	NM_003045
SLC7A1	hsa-miR-4306	81.0111	NM_003045
SLC7A1	hsa-miR-3529-3p	80.5314	NM_003045
SLC7A1	hsa-miR-4698	80.0963	NM_003045

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Motifs and transcription factors (TFs) regulating SLC7A1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SLC7A1	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
SLC7A1	taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAP	ATF4; CEBPD (directAnnotation).
SLC7A1	metacluster_156.2	ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
SLC7A1	taipale_tf_pairs__ATF4_CEBPB_NNATGAYGCAAYN_CAP	ATF4; CEBPB (directAnnotation).
SLC7A1	metacluster_52.11	ZNF184 (directAnnotation).
SLC7A1	metacluster_98.1	ZNF524 (directAnnotation).
SLC7A1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
SLC7A1	metacluster_7.13	ZFX (directAnnotation).
SLC7A1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SLC7A1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
SLC7A1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SLC7A1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
SLC7A1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
SLC7A1	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
SLC7A1	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
SLC7A1	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
SLC7A1	metacluster_81.7	CREB1 (directAnnotation).
SLC7A1	taipale_tf_pairs__ETV5_HOXB13_NNCGGANGNNNTWAA_CAP	ETV5; HOXB13 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
SLC7A1	"Arginine"	DB00125	small molecule
SLC7A1	"Lysine"	DB00123	small molecule
SLC7A1	"Ornithine"	DB00129	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."