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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: SLC6A8

Summary for SLC6A8

Gene information	Gene symbol	SLC6A8
	Ensembl ID	ENSG00000130821
	Entrez ID	6535
	Gene name	solute carrier family 6 member 8
	Synonyms	CRT\|CRT-1\|CRT1\|CRTR\|CT1
	Gene type	protein_coding
	UniProtAcc	P48029

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Dataset with differentially expressed gene: SLC6A8

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.878003	7.98e-37
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.62964	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.44182	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.452947	9.75e-40

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Expression of SLC6A8 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SLC6A8

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SLC6A8

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SLC6A8	hsa-miR-19b-3p	96.0044	NM_001142805
SLC6A8	hsa-miR-19a-3p	96.0044	NM_001142805
SLC6A8	hsa-miR-3148	95.8012	NM_001142805
SLC6A8	hsa-miR-6769b-5p	90.9197	NM_001142805
SLC6A8	hsa-miR-4694-3p	90.8278	NM_001142805
SLC6A8	hsa-miR-19b-2-5p	90.518	NM_001142805
SLC6A8	hsa-miR-19a-5p	90.518	NM_001142805
SLC6A8	hsa-miR-19b-1-5p	90.518	NM_001142805
SLC6A8	hsa-miR-185-3p	90.3659	NM_001142805
SLC6A8	hsa-miR-137-3p	90.3008	NM_001142805
SLC6A8	hsa-miR-92a-2-5p	88.9011	NM_001142805
SLC6A8	hsa-miR-4774-3p	88.3692	NM_001142805
SLC6A8	hsa-miR-585-5p	87.9302	NM_001142805
SLC6A8	hsa-miR-6769a-5p	87.9116	NM_001142805
SLC6A8	hsa-miR-3121-5p	87.4688	NM_001142805
SLC6A8	hsa-miR-4639-5p	87.2327	NM_001142805
SLC6A8	hsa-miR-381-3p	86.9671	NM_001142805
SLC6A8	hsa-miR-300	86.9671	NM_001142805
SLC6A8	hsa-miR-541-3p	86.2114	NM_001142805
SLC6A8	hsa-miR-654-5p	86.2114	NM_001142805
SLC6A8	hsa-miR-3689e	85.5821	NM_001142805
SLC6A8	hsa-miR-3689a-5p	85.5821	NM_001142805
SLC6A8	hsa-miR-3689f	85.5821	NM_001142805
SLC6A8	hsa-miR-3689b-5p	85.5821	NM_001142805
SLC6A8	hsa-miR-377-3p	85.4562	NM_001142805
SLC6A8	hsa-miR-342-3p	85.3432	NM_001142805
SLC6A8	hsa-miR-3688-3p	85.192	NM_001142805
SLC6A8	hsa-miR-138-5p	84.4682	NM_001142805
SLC6A8	hsa-miR-4487	82.3406	NM_001142805
SLC6A8	hsa-miR-3145-3p	80.4595	NM_001142805

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Motifs and transcription factors (TFs) regulating SLC6A8

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SLC6A8	transfac_pro__M06071	ZNF814 (directAnnotation).
SLC6A8	swissregulon__hs__ETV6	ETV6 (directAnnotation).
SLC6A8	transfac_pro__M04950	EGR1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
SLC6A8	"Creatine"	DB00148	small molecule
SLC6A8	"Phosphocreatine"	DB13191	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."