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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SLC5A3

Summary for SLC5A3

Gene information	Gene symbol	SLC5A3
	Ensembl ID	ENSG00000198743
	Entrez ID	6526
	Gene name	solute carrier family 5 member 3
	Synonyms	SMIT\|SMIT1
	Gene type	protein_coding
	UniProtAcc	P53794

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Dataset with differentially expressed gene: SLC5A3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.30448	0.00e+00

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Expression of SLC5A3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SLC5A3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SLC5A3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SLC5A3	hsa-miR-544a	98.0105	NM_006933
SLC5A3	hsa-miR-6738-3p	97.9499	NM_006933
SLC5A3	hsa-miR-335-3p	97.2814	NM_006933
SLC5A3	hsa-miR-3160-5p	96.9779	NM_006933
SLC5A3	hsa-miR-4668-5p	96.6957	NM_006933
SLC5A3	hsa-miR-330-5p	96.5424	NM_006933
SLC5A3	hsa-miR-326	96.0143	NM_006933
SLC5A3	hsa-miR-204-3p	95.7513	NM_006933
SLC5A3	hsa-miR-4646-5p	95.7513	NM_006933
SLC5A3	hsa-miR-1283	93.8821	NM_006933
SLC5A3	hsa-miR-12136	93.5176	NM_006933
SLC5A3	hsa-miR-196a-1-3p	92.5604	NM_006933
SLC5A3	hsa-miR-548k	92.4695	NM_006933
SLC5A3	hsa-miR-548av-5p	92.4695	NM_006933
SLC5A3	hsa-miR-3529-3p	92.1264	NM_006933
SLC5A3	hsa-miR-6817-3p	91.973	NM_006933
SLC5A3	hsa-miR-30d-3p	91.0647	NM_006933
SLC5A3	hsa-miR-30a-3p	91.0647	NM_006933
SLC5A3	hsa-miR-30e-3p	91.0647	NM_006933
SLC5A3	hsa-miR-8054	90.7884	NM_006933
SLC5A3	hsa-miR-587	90.4641	NM_006933
SLC5A3	hsa-miR-548c-3p	90.1155	NM_006933
SLC5A3	hsa-miR-9851-5p	89.4735	NM_006933
SLC5A3	hsa-miR-6828-3p	88.4233	NM_006933
SLC5A3	hsa-miR-6873-3p	87.4304	NM_006933
SLC5A3	hsa-miR-6071	87.2059	NM_006933
SLC5A3	hsa-miR-4659b-3p	86.9326	NM_006933
SLC5A3	hsa-miR-4659a-3p	86.9326	NM_006933
SLC5A3	hsa-miR-3613-3p	86.5622	NM_006933
SLC5A3	hsa-miR-7151-5p	86.4481	NM_006933
SLC5A3	hsa-miR-532-5p	86.4404	NM_006933
SLC5A3	hsa-miR-548u	86.4343	NM_006933
SLC5A3	hsa-miR-7161-5p	86.2016	NM_006933
SLC5A3	hsa-miR-4446-5p	86.1362	NM_006933
SLC5A3	hsa-miR-4282	85.9087	NM_006933
SLC5A3	hsa-miR-3681-3p	85.9019	NM_006933
SLC5A3	hsa-miR-4700-3p	85.7084	NM_006933
SLC5A3	hsa-miR-9-5p	85.6226	NM_006933
SLC5A3	hsa-miR-24-2-5p	85.2278	NM_006933
SLC5A3	hsa-miR-24-1-5p	85.2278	NM_006933
SLC5A3	hsa-miR-622	84.7668	NM_006933
SLC5A3	hsa-miR-218-5p	84.7111	NM_006933
SLC5A3	hsa-miR-4524a-3p	84.2014	NM_006933
SLC5A3	hsa-miR-1468-3p	83.5215	NM_006933
SLC5A3	hsa-miR-4709-3p	83.5015	NM_006933
SLC5A3	hsa-miR-153-5p	83.2982	NM_006933
SLC5A3	hsa-miR-128-3p	82.9485	NM_006933
SLC5A3	hsa-miR-216a-3p	82.9485	NM_006933
SLC5A3	hsa-miR-1285-5p	82.6487	NM_006933
SLC5A3	hsa-miR-501-5p	82.4605	NM_006933

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Motifs and transcription factors (TFs) regulating SLC5A3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SLC5A3	transfac_pro__M05981	ZNF233 (directAnnotation).
SLC5A3	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
SLC5A3	transfac_pro__M04950	EGR1 (directAnnotation).
SLC5A3	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
SLC5A3	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).
SLC5A3	transfac_pro__M06032	ZNF727 (directAnnotation).
SLC5A3	transfac_pro__M06135	ZNF28 (directAnnotation).
SLC5A3	metacluster_172.6	CHD2; E2F1 (directAnnotation).
SLC5A3	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."