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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SLC40A1

Summary for SLC40A1

Gene information	Gene symbol	SLC40A1
	Ensembl ID	ENSG00000138449
	Entrez ID	30061
	Gene name	solute carrier family 40 member 1
	Synonyms	FPN1\|HFE4\|IREG1\|MTP1\|SLC11A3
	Gene type	protein_coding
	UniProtAcc	Q9NP59

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Dataset with differentially expressed gene: SLC40A1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Mono/Macro	-0.461868	2.34e-16
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	-1.55482	1.94e-03
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.453901	1.04e-19
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	0.264184	4.61e-26

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Expression of SLC40A1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SLC40A1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SLC40A1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SLC40A1	hsa-miR-17-5p	99.4526	NM_014585
SLC40A1	hsa-miR-20a-5p	99.4526	NM_014585
SLC40A1	hsa-miR-519d-3p	99.4526	NM_014585
SLC40A1	hsa-miR-93-5p	99.4526	NM_014585
SLC40A1	hsa-miR-106a-5p	99.4526	NM_014585
SLC40A1	hsa-miR-106b-5p	99.4526	NM_014585
SLC40A1	hsa-miR-20b-5p	99.4526	NM_014585
SLC40A1	hsa-miR-526b-3p	98.7356	NM_014585
SLC40A1	hsa-miR-302e	94.8106	NM_014585
SLC40A1	hsa-miR-524-5p	94.7028	NM_014585
SLC40A1	hsa-miR-520d-5p	94.7028	NM_014585
SLC40A1	hsa-miR-628-3p	94.3342	NM_014585
SLC40A1	hsa-miR-1183	92.4934	NM_014585
SLC40A1	hsa-miR-5680	92.3398	NM_014585
SLC40A1	hsa-miR-520d-3p	92.1651	NM_014585
SLC40A1	hsa-miR-520a-3p	92.1651	NM_014585
SLC40A1	hsa-miR-302b-3p	92.1651	NM_014585
SLC40A1	hsa-miR-302d-3p	92.1651	NM_014585
SLC40A1	hsa-miR-372-3p	92.1651	NM_014585
SLC40A1	hsa-miR-302c-3p	92.1651	NM_014585
SLC40A1	hsa-miR-302a-3p	92.1651	NM_014585
SLC40A1	hsa-miR-520e-3p	92.1651	NM_014585
SLC40A1	hsa-miR-520c-3p	92.1651	NM_014585
SLC40A1	hsa-miR-520b-3p	92.1651	NM_014585
SLC40A1	hsa-miR-10393-5p	92.1301	NM_014585
SLC40A1	hsa-miR-17-3p	91.473	NM_014585
SLC40A1	hsa-miR-373-3p	91.1175	NM_014585
SLC40A1	hsa-miR-539-3p	90.1595	NM_014585
SLC40A1	hsa-miR-5681a	89.265	NM_014585
SLC40A1	hsa-miR-485-3p	88.9675	NM_014585
SLC40A1	hsa-miR-101-5p	87.6553	NM_014585
SLC40A1	hsa-miR-4680-3p	86.6762	NM_014585
SLC40A1	hsa-miR-4659a-3p	86.2215	NM_014585
SLC40A1	hsa-miR-4659b-3p	86.2215	NM_014585
SLC40A1	hsa-miR-553	85.2791	NM_014585
SLC40A1	hsa-miR-519b-3p	84.9429	NM_014585
SLC40A1	hsa-miR-519a-3p	84.9429	NM_014585
SLC40A1	hsa-miR-519c-3p	84.9429	NM_014585
SLC40A1	hsa-miR-6826-5p	84.6871	NM_014585
SLC40A1	hsa-miR-1-5p	82.2065	NM_014585
SLC40A1	hsa-miR-4698	82.0069	NM_014585
SLC40A1	hsa-miR-8063	82.0069	NM_014585
SLC40A1	hsa-miR-6818-5p	80.1442	NM_014585

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Motifs and transcription factors (TFs) regulating SLC40A1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SLC40A1	swissregulon__hs__HBP1	HBP1 (directAnnotation).
SLC40A1	transfac_pro__M01298	MECP2 (directAnnotation).
SLC40A1	transfac_pro__M06099	ZNF14 (directAnnotation).
SLC40A1	transfac_pro__M01973	PLAG1 (directAnnotation).
SLC40A1	transfac_public__M00051	NFKB1 (directAnnotation).
SLC40A1	tfdimers__MD00046	GATA1; GATA2; GATA3; GATA4; GATA5; GATA6; SMAD4 (directAnnotation).
SLC40A1	transfac_pro__M06071	ZNF814 (directAnnotation).
SLC40A1	homer__ATTGCGCAAC_CEBP	CEBPB (inferredBy_Orthology).
SLC40A1	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
SLC40A1	metacluster_143.13	ZBTB7A (directAnnotation).
SLC40A1	taipale_tf_pairs__TEAD4_CEBPD_RGWATGYNNTTRCGYAAN_CAP	CEBPD; TEAD4 (directAnnotation).
SLC40A1	transfac_pro__M05845	ZSCAN29 (directAnnotation).
SLC40A1	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
SLC40A1	taipale_tf_pairs__ETV2_CEBPD_RSCGGANNTTGCGYAAN_CAP_repr	CEBPD; ETV2 (directAnnotation).
SLC40A1	metacluster_52.13	LEF1; LEF1; LEF1; LEF1; TCF7; TCF7; TCF7L1; TCF7L1 (directAnnotation).
SLC40A1	taipale_tf_pairs__ERF_CEBPD_RSMGGAANTTGCGYAAN_CAP	CEBPD; ERF (directAnnotation).
SLC40A1	tfdimers__MD00129	CRX; NKX3-2 (directAnnotation).
SLC40A1	hdpi__FLI1	FLI1 (directAnnotation).
SLC40A1	taipale_tf_pairs__ETV2_PAX5_ACCGGANNTACGCNNNNNYR_CAP	ETV2; PAX5 (directAnnotation).
SLC40A1	taipale_tf_pairs__FLI1_CEBPD_RNCGGANNTTGCGCAAN_CAP	CEBPD; FLI1 (directAnnotation).
SLC40A1	hdpi__ETV4	ETV4 (directAnnotation).
SLC40A1	taipale_tf_pairs__ELK1_PAX5_RSCGGAACYACGCWYSANTG_CAP_repr	ELK1; PAX5 (directAnnotation).
SLC40A1	swissregulon__hs__SPI1	SPI1 (directAnnotation).
SLC40A1	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
SLC40A1	swissregulon__hs__ELF2	ELF2 (directAnnotation).
SLC40A1	tfdimers__MD00158	DBP; ZNF354C (directAnnotation).
SLC40A1	transfac_pro__M06165	ZNF570 (inferredBy_Orthology).
SLC40A1	transfac_pro__M06265	ZNF791 (directAnnotation).
SLC40A1	transfac_pro__M01105	ZNF350 (directAnnotation).
SLC40A1	transfac_pro__M06610	ZNF764 (directAnnotation).
SLC40A1	kznf__CTCF_Rhee2011.3_ChIP-exo	CTCF (directAnnotation).
SLC40A1	taipale_tf_pairs__ETV2_DLX2_RCCGGAANNNNNNYAATTA_CAP_repr	DLX2; ETV2 (directAnnotation).
SLC40A1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
SLC40A1	metacluster_22.20	MAFG (directAnnotation).
SLC40A1	metacluster_80.6	ZIC4 (directAnnotation).
SLC40A1	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
SLC40A1	metacluster_22.11	NFE2 (directAnnotation).
SLC40A1	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
SLC40A1	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
SLC40A1	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
SLC40A1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."