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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SLC39A9

Summary for SLC39A9

Gene information	Gene symbol	SLC39A9
	Ensembl ID	ENSG00000029364
	Entrez ID	55334
	Gene name	solute carrier family 39 member 9
	Synonyms	FLJ11274
	Gene type	protein_coding
	UniProtAcc	Q9NUM3

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Dataset with differentially expressed gene: SLC39A9

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.273601	4.34e-29

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Expression of SLC39A9 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SLC39A9

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SLC39A9

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SLC39A9	hsa-miR-182-5p	99.0484	NM_001252148
SLC39A9	hsa-miR-9-5p	98.2462	NM_001252148
SLC39A9	hsa-miR-548c-3p	97.2423	NM_001252148
SLC39A9	hsa-miR-4282	96.2419	NM_001252148
SLC39A9	hsa-miR-889-3p	95.8031	NM_018375
SLC39A9	hsa-miR-4319	95.312	NM_001252148
SLC39A9	hsa-miR-513b-5p	95.1033	NM_001252148
SLC39A9	hsa-miR-93-3p	95.0393	NM_001252148
SLC39A9	hsa-miR-2052	94.9011	NM_018375
SLC39A9	hsa-miR-125b-5p	94.176	NM_001252148
SLC39A9	hsa-miR-125a-5p	94.176	NM_001252148
SLC39A9	hsa-miR-1271-5p	93.5564	NM_001252148
SLC39A9	hsa-miR-96-5p	93.4834	NM_001252148
SLC39A9	hsa-miR-12133	93.4392	NM_001252148
SLC39A9	hsa-miR-206	92.3846	NM_001252148
SLC39A9	hsa-miR-1-3p	92.3846	NM_001252148
SLC39A9	hsa-miR-4796-3p	92.3316	NM_001252150
SLC39A9	hsa-miR-3714	91.1671	NM_001252148
SLC39A9	hsa-miR-1233-3p	90.2041	NM_001252148
SLC39A9	hsa-miR-3910	90.1345	NM_001252148
SLC39A9	hsa-miR-4716-5p	89.6576	NM_001252148
SLC39A9	hsa-miR-9902	89.5012	NM_001252150
SLC39A9	hsa-miR-3059-3p	89.0295	NM_018375
SLC39A9	hsa-miR-1252-5p	88.6396	NM_018375
SLC39A9	hsa-miR-613	87.7377	NM_001252148
SLC39A9	hsa-miR-138-2-3p	87.3897	NM_018375
SLC39A9	hsa-miR-670-5p	87.0457	NM_001252148
SLC39A9	hsa-miR-4800-5p	86.4698	NM_001252150
SLC39A9	hsa-miR-4475	84.9385	NM_001252150
SLC39A9	hsa-miR-6809-5p	84.6622	NM_001252148
SLC39A9	hsa-miR-34b-3p	84.4828	NM_018375
SLC39A9	hsa-miR-551b-5p	84.3989	NM_018375
SLC39A9	hsa-miR-203a-3p	84.3578	NM_018375
SLC39A9	hsa-miR-506-3p	83.9375	NM_001252148
SLC39A9	hsa-miR-124-3p	83.9375	NM_001252148
SLC39A9	hsa-miR-361-5p	83.9285	NM_001252150
SLC39A9	hsa-miR-3168	82.7252	NM_001252148
SLC39A9	hsa-miR-4470	81.5857	NM_001252148
SLC39A9	hsa-miR-497-5p	81.4741	NM_001252148
SLC39A9	hsa-miR-4662a-5p	81.4024	NM_001252148
SLC39A9	hsa-miR-582-5p	80.7836	NM_018375
SLC39A9	hsa-miR-487b-5p	80.0529	NM_018375
SLC39A9	hsa-miR-487a-5p	80.0529	NM_018375

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Motifs and transcription factors (TFs) regulating SLC39A9

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SLC39A9	metacluster_135.11	NR2C2 (directAnnotation).
SLC39A9	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."