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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: SLC39A10

Summary for SLC39A10

Gene informationGene symbol

SLC39A10

Ensembl ID

ENSG00000196950

Entrez ID

57181

Gene namesolute carrier family 39 member 10
SynonymsDKFZp564L2123|FLJ90515|KIAA1265
Gene typeprotein_coding
UniProtAcc

NA


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Dataset with differentially expressed gene: SLC39A10

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE140440

DU145 and PC cell linesCell lineProstate cancerProstate cancerChemotherapydocetaxelNAMalignant cells0.7923958.87e-07

GSE168668

LNCaP cell lineCell lineProstate cancerProstate cancerTargeted therapyenzalutamideNAMalignant cells-0.3717220.00e+00

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Expression of SLC39A10 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to SLC39A10

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SLC39A10

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
SLC39A10hsa-miR-1-3p97.6495NM_001127257
SLC39A10hsa-miR-20697.6495NM_001127257
SLC39A10hsa-miR-61397.1186NM_001127257
SLC39A10hsa-miR-425296.9413NM_001127257
SLC39A10hsa-miR-561-3p96.1717NM_020342
SLC39A10hsa-miR-5582-3p96.1591NM_020342
SLC39A10hsa-miR-471996.0825NM_020342
SLC39A10hsa-miR-366295.3828NM_020342
SLC39A10hsa-miR-426995.0254NM_001127257
SLC39A10hsa-miR-431094.3984NM_001127257
SLC39A10hsa-miR-3129-5p93.9586NM_001127257
SLC39A10hsa-miR-199b-3p93.9586NM_001127257
SLC39A10hsa-miR-199a-3p93.9586NM_001127257
SLC39A10hsa-miR-470593.8504NM_001127257
SLC39A10hsa-miR-426793.5377NM_001127257
SLC39A10hsa-miR-5011-5p93.5363NM_001127257
SLC39A10hsa-miR-806893.5248NM_020342
SLC39A10hsa-miR-6715b-5p93.4738NM_001127257
SLC39A10hsa-miR-7157-5p92.6125NM_001127257
SLC39A10hsa-miR-101-3p92.3089NM_020342
SLC39A10hsa-miR-364690.6441NM_020342
SLC39A10hsa-miR-222-5p90.3139NM_001127257
SLC39A10hsa-miR-106a-3p88.7761NM_001127257
SLC39A10hsa-miR-805788.3866NM_001127257
SLC39A10hsa-miR-377-3p88.0047NM_001127257
SLC39A10hsa-miR-431187.8137NM_020342
SLC39A10hsa-miR-3145-3p87.6178NM_020342
SLC39A10hsa-miR-568987.4256NM_001127257
SLC39A10hsa-miR-548b-3p87.3362NM_020342
SLC39A10hsa-miR-56986.806NM_001127257
SLC39A10hsa-miR-6720-5p86.7641NM_020342
SLC39A10hsa-miR-6512-3p86.7641NM_020342
SLC39A10hsa-miR-426386.6686NM_001127257
SLC39A10hsa-miR-4782-3p86.3132NM_001127257
SLC39A10hsa-miR-6766-3p86.3132NM_001127257
SLC39A10hsa-miR-219a-5p86.3132NM_001127257
SLC39A10hsa-miR-59286.1784NM_020342
SLC39A10hsa-miR-16-5p85.8865NM_001127257
SLC39A10hsa-miR-195-5p85.8865NM_001127257
SLC39A10hsa-miR-15b-5p85.8865NM_001127257
SLC39A10hsa-miR-15a-5p85.8865NM_001127257
SLC39A10hsa-miR-61885.8648NM_001127257
SLC39A10hsa-miR-4760-3p85.5585NM_001127257
SLC39A10hsa-miR-3065-3p85.359NM_001127257
SLC39A10hsa-miR-30d-3p85.1214NM_001127257
SLC39A10hsa-miR-30e-3p85.1214NM_001127257
SLC39A10hsa-miR-30a-3p85.1214NM_001127257
SLC39A10hsa-miR-1212284.3859NM_001127257
SLC39A10hsa-miR-469283.9592NM_001127257
SLC39A10hsa-miR-4742-5p83.9592NM_001127257
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Motifs and transcription factors (TFs) regulating SLC39A10

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
SLC39A10kznf__ZNF594_Schmitges2016_RCADEZNF594 (directAnnotation).
SLC39A10metacluster_195.2EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
SLC39A10kznf__ZBTB14_Schmitges2016_RCADEZBTB14 (directAnnotation).
SLC39A10transfac_pro__M04617ZBTB7A (directAnnotation).
SLC39A10metacluster_3.5KLF14; KLF15; KLF15; KLF16 (directAnnotation).
SLC39A10taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_methZNF460 (directAnnotation).
SLC39A10taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_methE2F2 (directAnnotation).
SLC39A10transfac_pro__M07387ZBTB7A (directAnnotation).
SLC39A10transfac_pro__M07436WT1 (directAnnotation).
SLC39A10transfac_pro__M07461KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
SLC39A10transfac_pro__M00716ZBTB14 (directAnnotation).
SLC39A10swissregulon__hs__CHD1CHD1 (directAnnotation).
SLC39A10hdpi__HIP2UBE2K (directAnnotation).
SLC39A10taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_reprGCM1; SPDEF (directAnnotation).
SLC39A10metacluster_170.2KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
SLC39A10transfac_pro__M04893TAF1 (directAnnotation).
SLC39A10transfac_pro__M03876ZBTB33 (directAnnotation).
SLC39A10metacluster_15.2E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
SLC39A10metacluster_133.1ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SLC39A10kznf__ZNF441_Imbeault2017_RP_RCADEZNF441 (directAnnotation).
SLC39A10transfac_pro__M01219SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SLC39A10metacluster_3.7SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
SLC39A10taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAPE2F3; HES7 (directAnnotation).
SLC39A10transfac_pro__M02089E2F3 (directAnnotation).
SLC39A10transfac_pro__M00803E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
SLC39A10transfac_pro__M04817ZBTB33 (directAnnotation).
SLC39A10metacluster_143.13ZBTB7A (directAnnotation).
SLC39A10transfac_pro__M02861GATA6 (inferredBy_Orthology).
SLC39A10tfdimers__MD00483ZBTB14 (directAnnotation).
SLC39A10cisbp__M07938E2F1 (directAnnotation).
SLC39A10cisbp__M00968MTF2 (directAnnotation).
SLC39A10jaspar__MA0535.1SMAD9 (inferredBy_Orthology).
SLC39A10metacluster_15.1E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
SLC39A10taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_reprE2F1; HES7 (directAnnotation).
SLC39A10metacluster_111.6GMEB1; GMEB2 (directAnnotation).
SLC39A10jaspar__MA1122.1TFDP1 (directAnnotation).
SLC39A10taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAPETV5; HES7 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."