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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SLC39A1

Summary for SLC39A1

Gene information	Gene symbol	SLC39A1
	Ensembl ID	ENSG00000143570
	Entrez ID	27173
	Gene name	solute carrier family 39 member 1
	Synonyms	ZIP1\|ZIRTL
	Gene type	protein_coding
	UniProtAcc	Q9NY26

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Dataset with differentially expressed gene: SLC39A1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.25918	1.71e-17
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.301535	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.452811	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.556052	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.49653	2.00e-28
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.640346	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.400482	9.93e-20
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.609105	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.535201	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.255509	0.00e+00

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Expression of SLC39A1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SLC39A1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SLC39A1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SLC39A1	hsa-miR-96-5p	96.8262	NM_001271961
SLC39A1	hsa-miR-12133	96.5639	NM_001271961
SLC39A1	hsa-miR-1271-5p	96.4837	NM_001271961
SLC39A1	hsa-miR-6892-3p	95.2288	NM_001271958
SLC39A1	hsa-miR-182-5p	94.1681	NM_001271961
SLC39A1	hsa-miR-376a-5p	94.1607	NM_001271961
SLC39A1	hsa-miR-6852-5p	92.9308	NM_001271961
SLC39A1	hsa-miR-6737-3p	92.3227	NM_001271961
SLC39A1	hsa-miR-5008-3p	92.3227	NM_001271961
SLC39A1	hsa-miR-7157-3p	92.3227	NM_001271961
SLC39A1	hsa-miR-4744	92.1221	NM_001271958
SLC39A1	hsa-miR-7150	90.8996	NM_001271961
SLC39A1	hsa-miR-3121-3p	90.583	NM_001271961
SLC39A1	hsa-miR-6081	87.1701	NM_001271961
SLC39A1	hsa-miR-6834-3p	86.33	NM_001271958
SLC39A1	hsa-miR-4660	84.8995	NM_001271961
SLC39A1	hsa-miR-133a-3p	82.9642	NM_001271958
SLC39A1	hsa-miR-133b	82.9642	NM_001271958
SLC39A1	hsa-miR-1207-5p	81.8566	NM_001271958
SLC39A1	hsa-miR-4693-5p	81.5401	NM_001271961
SLC39A1	hsa-miR-3163	80.7871	NM_001271961

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Motifs and transcription factors (TFs) regulating SLC39A1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SLC39A1	swissregulon__hs__ELF2	ELF2 (directAnnotation).
SLC39A1	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
SLC39A1	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
SLC39A1	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
SLC39A1	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
SLC39A1	jaspar__MA0502.2	NFYB (directAnnotation).
SLC39A1	metacluster_183.4	ETS1 (inferredBy_Orthology).
SLC39A1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
SLC39A1	transfac_pro__M00492	STAT1 (directAnnotation).
SLC39A1	hdpi__FLI1	FLI1 (directAnnotation).
SLC39A1	transfac_public__M00041	ATF2; JUN (directAnnotation).
SLC39A1	jaspar__MA1933.1	SREBF2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."