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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SLC38A1

Summary for SLC38A1

Gene information	Gene symbol	SLC38A1
	Ensembl ID	ENSG00000111371
	Entrez ID	81539
	Gene name	solute carrier family 38 member 1
	Synonyms	ATA1\|NAT2\|SAT1
	Gene type	protein_coding
	UniProtAcc	Q9H2H9

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Dataset with differentially expressed gene: SLC38A1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.588906	1.46e-02
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Plasma cells	-0.276832	6.50e-04
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	pDCs	0.434554	4.52e-03
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.318816	1.10e-42
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.404025	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.311384	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.3345	8.00e-06
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.250165	7.15e-44
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.289882	7.32e-36
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	B cells	0.331217	2.34e-04
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.463563	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.345104	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.288211	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.329481	4.08e-40
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.582659	0.00e+00
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	0.277304	2.14e-15

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Expression of SLC38A1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SLC38A1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SLC38A1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SLC38A1	hsa-miR-593-3p	99.063	NM_001278388
SLC38A1	hsa-miR-6809-3p	97.7789	NM_001278388
SLC38A1	hsa-miR-3686	97.3955	NM_001278389
SLC38A1	hsa-miR-4276	95.0609	NM_001278388
SLC38A1	hsa-miR-6873-5p	95.0478	NM_001278389
SLC38A1	hsa-miR-4652-3p	93.885	NM_001278388
SLC38A1	hsa-miR-548aj-3p	93.8067	NM_001278389
SLC38A1	hsa-miR-548x-3p	93.8067	NM_001278389
SLC38A1	hsa-miR-4743-3p	93.6936	NM_001278388
SLC38A1	hsa-miR-548ae-3p	92.4143	NM_001278389
SLC38A1	hsa-miR-548ah-3p	92.4143	NM_001278389
SLC38A1	hsa-miR-548am-3p	92.4143	NM_001278389
SLC38A1	hsa-miR-548aq-3p	92.4143	NM_001278389
SLC38A1	hsa-miR-548j-3p	92.4143	NM_001278389
SLC38A1	hsa-miR-1468-3p	92.3302	NM_001278388
SLC38A1	hsa-miR-2110	92.2544	NM_001278388
SLC38A1	hsa-miR-5696	91.5271	NM_001278388
SLC38A1	hsa-miR-4505	90.9469	NM_001278390
SLC38A1	hsa-miR-5787	90.9469	NM_001278390
SLC38A1	hsa-miR-10527-5p	90.689	NM_001278389
SLC38A1	hsa-miR-7851-3p	90.5941	NM_001278388
SLC38A1	hsa-miR-450a-2-3p	89.5023	NM_001278388
SLC38A1	hsa-miR-146a-3p	89.368	NM_001278389
SLC38A1	hsa-miR-3188	89.3632	NM_001278388
SLC38A1	hsa-miR-138-2-3p	88.7849	NM_001278389
SLC38A1	hsa-miR-4261	88.6164	NM_001278388
SLC38A1	hsa-miR-548f-5p	88.5341	NM_001278388
SLC38A1	hsa-miR-548g-5p	88.5341	NM_001278388
SLC38A1	hsa-miR-548aj-5p	88.5341	NM_001278388
SLC38A1	hsa-miR-548x-5p	88.5341	NM_001278388
SLC38A1	hsa-miR-548aw	88.2885	NM_001278388
SLC38A1	hsa-miR-3168	88.1046	NM_001278389
SLC38A1	hsa-miR-6895-3p	87.855	NM_001278388
SLC38A1	hsa-miR-7157-3p	87.8065	NM_001278389
SLC38A1	hsa-miR-6737-3p	87.8065	NM_001278389
SLC38A1	hsa-miR-8075	87.4668	NM_001278389
SLC38A1	hsa-miR-374b-3p	87.4463	NM_001278389
SLC38A1	hsa-miR-146a-5p	87.1532	NM_001278389
SLC38A1	hsa-miR-7153-5p	87.1532	NM_001278389
SLC38A1	hsa-miR-146b-5p	87.1532	NM_001278389
SLC38A1	hsa-miR-33a-3p	86.7912	NM_001278388
SLC38A1	hsa-miR-520f-5p	86.6845	NM_001278388
SLC38A1	hsa-miR-3185	86.1607	NM_001278389
SLC38A1	hsa-miR-4516	85.6467	NM_001278389
SLC38A1	hsa-miR-4753-3p	84.89	NM_001278388
SLC38A1	hsa-miR-5008-3p	84.7939	NM_001278389
SLC38A1	hsa-miR-4695-3p	84.5599	NM_001278389
SLC38A1	hsa-miR-4679	84.3988	NM_001278388
SLC38A1	hsa-miR-4427	84.1553	NM_001278389
SLC38A1	hsa-miR-5692a	84.1323	NM_001278389

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Motifs and transcription factors (TFs) regulating SLC38A1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SLC38A1	swissregulon__hs__FOXD3	FOXD3 (directAnnotation).
SLC38A1	tfdimers__MD00456	E2F6; OVOL2 (directAnnotation).
SLC38A1	taipale_tf_pairs__ETV5_CEBPD_NSCGGANNTTRCGYAAN_CAP	CEBPD; ETV5 (directAnnotation).
SLC38A1	metacluster_188.3	FOXJ3; FOXJ3; FOXP1; FOXP1 (directAnnotation). FOXO1; FOXO4; FOXP1 (inferredBy_Orthology).
SLC38A1	metacluster_77.11	SOX12 (directAnnotation).
SLC38A1	metacluster_78.20	PAX7 (inferredBy_Orthology).
SLC38A1	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
SLC38A1	taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAP	ATF4; CEBPD (directAnnotation).
SLC38A1	transfac_pro__M01299	MECP2 (directAnnotation).
SLC38A1	transfac_pro__M06035	ZNF749 (directAnnotation).
SLC38A1	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
SLC38A1	metacluster_52.11	ZNF184 (directAnnotation).
SLC38A1	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
SLC38A1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
SLC38A1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
SLC38A1	transfac_pro__M04617	ZBTB7A (directAnnotation).
SLC38A1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
SLC38A1	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
SLC38A1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
SLC38A1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
SLC38A1	transfac_pro__M07387	ZBTB7A (directAnnotation).
SLC38A1	transfac_pro__M07436	WT1 (directAnnotation).
SLC38A1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
SLC38A1	transfac_pro__M00716	ZBTB14 (directAnnotation).
SLC38A1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
SLC38A1	hdpi__HIP2	UBE2K (directAnnotation).
SLC38A1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
SLC38A1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
SLC38A1	transfac_pro__M04893	TAF1 (directAnnotation).
SLC38A1	transfac_pro__M03876	ZBTB33 (directAnnotation).
SLC38A1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
SLC38A1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SLC38A1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SLC38A1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
SLC38A1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
SLC38A1	cisbp__M00788	ZFY (inferredBy_Orthology).
SLC38A1	metacluster_7.13	ZFX (directAnnotation).
SLC38A1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
SLC38A1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SLC38A1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
SLC38A1	transfac_pro__M02913	SP140 (inferredBy_Orthology).
SLC38A1	transfac_pro__M02898	SMAD3 (directAnnotation).
SLC38A1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
SLC38A1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
SLC38A1	transfac_pro__M00430	E2F1 (directAnnotation).
SLC38A1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
SLC38A1	hdpi__ZNF304	ZNF304 (directAnnotation).
SLC38A1	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
SLC38A1	transfac_pro__M00938	E2F1 (directAnnotation).
SLC38A1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."