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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SLC35F6

Summary for SLC35F6

Gene information	Gene symbol	SLC35F6
	Ensembl ID	ENSG00000213699
	Entrez ID	54978
	Gene name	solute carrier family 35 member F6
	Synonyms	ANT2BP\|C2orf18\|FLJ20555\|TANGO9
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SLC35F6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.292972	1.32e-30
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.252663	2.15e-04

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Expression of SLC35F6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SLC35F6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SLC35F6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SLC35F6	hsa-miR-1827	99.4045	NM_017877
SLC35F6	hsa-miR-616-5p	92.3025	NM_017877
SLC35F6	hsa-miR-371b-5p	92.3025	NM_017877
SLC35F6	hsa-miR-373-5p	92.3025	NM_017877
SLC35F6	hsa-miR-627-3p	92.0082	NM_017877
SLC35F6	hsa-miR-4726-3p	91.4002	NM_017877
SLC35F6	hsa-miR-1304-5p	91.0157	NM_017877
SLC35F6	hsa-miR-4659b-3p	90.6568	NM_017877
SLC35F6	hsa-miR-4659a-3p	90.6568	NM_017877
SLC35F6	hsa-miR-29b-1-5p	89.5386	NM_017877
SLC35F6	hsa-miR-4728-5p	89.1415	NM_017877
SLC35F6	hsa-miR-6762-5p	86.4467	NM_017877
SLC35F6	hsa-miR-6845-5p	86.4467	NM_017877
SLC35F6	hsa-miR-511-5p	85.4273	NM_017877
SLC35F6	hsa-miR-6785-5p	85.1301	NM_017877
SLC35F6	hsa-miR-7106-5p	84.9518	NM_017877
SLC35F6	hsa-miR-3613-3p	83.6599	NM_017877
SLC35F6	hsa-miR-10394-5p	82.9168	NM_017877
SLC35F6	hsa-miR-1205	82.9168	NM_017877
SLC35F6	hsa-miR-6884-5p	82.7067	NM_017877
SLC35F6	hsa-miR-6799-5p	81.5125	NM_017877
SLC35F6	hsa-miR-6780a-5p	81.4764	NM_017877
SLC35F6	hsa-miR-4441	80.4332	NM_017877
SLC35F6	hsa-miR-149-3p	80.3372	NM_017877
SLC35F6	hsa-miR-6883-5p	80.3372	NM_017877

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Motifs and transcription factors (TFs) regulating SLC35F6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SLC35F6	kznf__PRDM1_modENCODE.2_ChIP-seq	PRDM1 (directAnnotation).
SLC35F6	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
SLC35F6	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."