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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SLC31A1

Summary for SLC31A1

Gene information	Gene symbol	SLC31A1
	Ensembl ID	ENSG00000136868
	Entrez ID	1317
	Gene name	solute carrier family 31 member 1
	Synonyms	COPT1\|CTR1\|hCTR1
	Gene type	protein_coding
	UniProtAcc	O15431

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Dataset with differentially expressed gene: SLC31A1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.338884	0.00e+00

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Expression of SLC31A1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SLC31A1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
SLC31A1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating SLC31A1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SLC31A1	hsa-miR-6867-5p	100	NM_001859
SLC31A1	hsa-miR-551b-5p	94.2121	NM_001859
SLC31A1	hsa-miR-6822-3p	93.9922	NM_001859
SLC31A1	hsa-miR-3910	93.3323	NM_001859
SLC31A1	hsa-miR-588	92.6355	NM_001859
SLC31A1	hsa-miR-4701-5p	92.6355	NM_001859
SLC31A1	hsa-miR-124-3p	92.2184	NM_001859
SLC31A1	hsa-miR-506-3p	92.2184	NM_001859
SLC31A1	hsa-miR-520h	91.4873	NM_001859
SLC31A1	hsa-miR-520g-3p	91.4873	NM_001859
SLC31A1	hsa-miR-8063	90.5082	NM_001859
SLC31A1	hsa-miR-7151-3p	90.3749	NM_001859
SLC31A1	hsa-miR-4448	89.7099	NM_001859
SLC31A1	hsa-miR-6721-5p	88.8997	NM_001859
SLC31A1	hsa-miR-224-5p	88.4196	NM_001859
SLC31A1	hsa-miR-4782-3p	87.8379	NM_001859
SLC31A1	hsa-miR-6766-3p	87.8379	NM_001859
SLC31A1	hsa-miR-219a-5p	87.8379	NM_001859
SLC31A1	hsa-miR-3154	87.3165	NM_001859
SLC31A1	hsa-miR-497-3p	86.9591	NM_001859
SLC31A1	hsa-miR-4438	86.4787	NM_001859
SLC31A1	hsa-miR-4711-5p	86.38	NM_001859
SLC31A1	hsa-miR-4534	84.6668	NM_001859
SLC31A1	hsa-miR-5582-5p	83.5856	NM_001859
SLC31A1	hsa-miR-3156-3p	82.7346	NM_001859
SLC31A1	hsa-miR-6787-3p	82.3078	NM_001859
SLC31A1	hsa-miR-6757-5p	81.5523	NM_001859
SLC31A1	hsa-miR-6778-3p	81.3118	NM_001859
SLC31A1	hsa-miR-504-3p	81.0538	NM_001859
SLC31A1	hsa-miR-760	80.5146	NM_001859
SLC31A1	hsa-miR-659-5p	80.3842	NM_001859

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Motifs and transcription factors (TFs) regulating SLC31A1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."