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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SLC30A7

Summary for SLC30A7

Gene information	Gene symbol	SLC30A7
	Ensembl ID	ENSG00000162695
	Entrez ID	148867
	Gene name	solute carrier family 30 member 7
	Synonyms	ZNT7\|ZnTL2
	Gene type	protein_coding
	UniProtAcc	Q8NEW0

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Dataset with differentially expressed gene: SLC30A7

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.293458	2.52e-44
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.325514	9.30e-35

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Expression of SLC30A7 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SLC30A7

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SLC30A7

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SLC30A7	hsa-miR-570-3p	99.8233	NM_133496
SLC30A7	hsa-miR-3671	99.0953	NM_001144884
SLC30A7	hsa-miR-6873-3p	98.7829	NM_133496
SLC30A7	hsa-miR-5688	98.664	NM_133496
SLC30A7	hsa-miR-495-3p	98.1532	NM_133496
SLC30A7	hsa-miR-659-3p	97.5929	NM_001144884
SLC30A7	hsa-miR-133b	97.5262	NM_133496
SLC30A7	hsa-miR-133a-3p	97.5262	NM_133496
SLC30A7	hsa-miR-6833-3p	97.1748	NM_133496
SLC30A7	hsa-miR-29b-1-5p	96.4739	NM_133496
SLC30A7	hsa-miR-548an	96.0999	NM_133496
SLC30A7	hsa-miR-4768-5p	96.0935	NM_133496
SLC30A7	hsa-miR-4652-3p	95.7587	NM_133496
SLC30A7	hsa-miR-506-3p	95.7466	NM_133496
SLC30A7	hsa-miR-124-3p	95.7466	NM_133496
SLC30A7	hsa-miR-3613-3p	95.6378	NM_133496
SLC30A7	hsa-miR-548h-3p	95.3482	NM_133496
SLC30A7	hsa-miR-548ac	95.3482	NM_133496
SLC30A7	hsa-miR-548z	95.3482	NM_133496
SLC30A7	hsa-miR-4743-3p	95.0535	NM_133496
SLC30A7	hsa-miR-548bb-3p	94.8262	NM_133496
SLC30A7	hsa-miR-548d-3p	94.8262	NM_133496
SLC30A7	hsa-miR-5697	94.5564	NM_133496
SLC30A7	hsa-miR-548x-3p	94.3723	NM_133496
SLC30A7	hsa-miR-548aj-3p	94.3723	NM_133496
SLC30A7	hsa-miR-3163	93.8106	NM_133496
SLC30A7	hsa-miR-548aq-3p	93.5709	NM_133496
SLC30A7	hsa-miR-548ae-3p	93.5709	NM_133496
SLC30A7	hsa-miR-3128	93.1537	NM_133496
SLC30A7	hsa-miR-4314	93.0744	NM_001144884
SLC30A7	hsa-miR-548j-3p	92.8494	NM_133496
SLC30A7	hsa-miR-548ah-3p	92.8494	NM_133496
SLC30A7	hsa-miR-548am-3p	92.8494	NM_133496
SLC30A7	hsa-miR-9851-5p	92.3131	NM_133496
SLC30A7	hsa-miR-5580-3p	92.0982	NM_001144884
SLC30A7	hsa-miR-4328	91.9495	NM_001144884
SLC30A7	hsa-miR-101-3p	91.5885	NM_133496
SLC30A7	hsa-miR-607	91.5847	NM_133496
SLC30A7	hsa-miR-5692a	91.5607	NM_001144884
SLC30A7	hsa-miR-3187-3p	90.9547	NM_001144884
SLC30A7	hsa-miR-3180-5p	90.8764	NM_133496
SLC30A7	hsa-miR-3646	90.8553	NM_001144884
SLC30A7	hsa-miR-590-3p	90.849	NM_133496
SLC30A7	hsa-miR-3121-3p	90.6675	NM_001144884
SLC30A7	hsa-miR-4291	90.001	NM_001144884
SLC30A7	hsa-miR-3686	89.7861	NM_001144884
SLC30A7	hsa-miR-340-5p	89.1669	NM_133496
SLC30A7	hsa-miR-4503	88.951	NM_001144884
SLC30A7	hsa-miR-3119	88.7895	NM_133496
SLC30A7	hsa-miR-5583-3p	88.5038	NM_133496

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Motifs and transcription factors (TFs) regulating SLC30A7

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SLC30A7	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."