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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: SLC2A1

Summary for SLC2A1

Gene information	Gene symbol	SLC2A1
	Ensembl ID	ENSG00000117394
	Entrez ID	6513
	Gene name	solute carrier family 2 member 1
	Synonyms	CSE\|DYT18\|DYT9\|GLUT\|GLUT-1\|GLUT1\|HTLVR
	Gene type	protein_coding
	UniProtAcc	P11166

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Dataset with differentially expressed gene: SLC2A1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.263902	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.260171	1.01e-07
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.319365	6.24e-13
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	1.00927	2.01e-05
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.50713	9.04e-17
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.256838	4.00e-16
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.378122	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.483128	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.349415	0.00e+00

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Expression of SLC2A1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SLC2A1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
SLC2A1	Irregularity in Drug Uptake and Drug Efflux
SLC2A1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating SLC2A1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SLC2A1	hsa-miR-5011-5p	95.7721	NM_006516
SLC2A1	hsa-miR-4427	93.4315	NM_006516
SLC2A1	hsa-miR-4758-5p	91.6555	NM_006516
SLC2A1	hsa-miR-1238-5p	91.6555	NM_006516
SLC2A1	hsa-miR-92a-1-5p	91.1495	NM_006516
SLC2A1	hsa-miR-6077	90.0119	NM_006516
SLC2A1	hsa-miR-6081	88.3826	NM_006516
SLC2A1	hsa-miR-148b-3p	87.8906	NM_006516
SLC2A1	hsa-miR-148a-3p	87.8906	NM_006516
SLC2A1	hsa-miR-152-3p	87.8906	NM_006516
SLC2A1	hsa-miR-4653-3p	86.7726	NM_006516
SLC2A1	hsa-miR-8055	86.2995	NM_006516
SLC2A1	hsa-miR-3664-3p	85.8893	NM_006516
SLC2A1	hsa-miR-4742-3p	85.8844	NM_006516
SLC2A1	hsa-miR-1263	84.4407	NM_006516
SLC2A1	hsa-miR-223-5p	83.6842	NM_006516
SLC2A1	hsa-miR-4518	81.4139	NM_006516
SLC2A1	hsa-miR-1266-5p	81.4139	NM_006516
SLC2A1	hsa-miR-6773-5p	81.3236	NM_006516
SLC2A1	hsa-miR-1284	81.1213	NM_006516
SLC2A1	hsa-miR-1277-5p	80.446	NM_006516
SLC2A1	hsa-miR-140-5p	80.3987	NM_006516
SLC2A1	hsa-miR-3163	80.1061	NM_006516
SLC2A1	hsa-miR-3140-3p	80.0424	NM_006516

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Motifs and transcription factors (TFs) regulating SLC2A1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SLC2A1	metacluster_7.13	ZFX (directAnnotation).
SLC2A1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SLC2A1	metacluster_182.10	ZFX (directAnnotation).
SLC2A1	jaspar__MA0079.5	SP1 (directAnnotation).
SLC2A1	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
SLC2A1	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
SLC2A1	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
SLC2A1	transfac_pro__M01253	CNOT3 (directAnnotation).
SLC2A1	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
SLC2A1	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
SLC2A1	dbtfbs__GMEB2_HepG2_ENCSR745VSQ_merged_N1	GMEB2 (directAnnotation).
SLC2A1	cisbp__M02645	ETS1 (directAnnotation).
SLC2A1	transfac_pro__M06340	ZNF790 (directAnnotation).
SLC2A1	hdpi__TP73	TP73 (directAnnotation).
SLC2A1	metacluster_22.13	MAFK (inferredBy_Orthology).
SLC2A1	metacluster_22.15	BACH1 (directAnnotation).
SLC2A1	metacluster_22.14	BACH1 (inferredBy_Orthology).
SLC2A1	metacluster_22.21	NFE2L2 (inferredBy_Orthology).
SLC2A1	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
SLC2A1	metacluster_30.4	BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).
SLC2A1	metacluster_22.11	NFE2 (directAnnotation).
SLC2A1	metacluster_22.32	NFE2L2 (directAnnotation).
SLC2A1	metacluster_22.25	NFE2L2 (directAnnotation).
SLC2A1	metacluster_22.20	MAFG (directAnnotation).
SLC2A1	metacluster_22.28	BACH1 (directAnnotation).
SLC2A1	metacluster_22.18	BACH2 (inferredBy_Orthology).
SLC2A1	metacluster_22.19	NFE2 (directAnnotation).
SLC2A1	metacluster_22.37	BACH1 (directAnnotation).
SLC2A1	metacluster_22.29	NFE2 (directAnnotation).
SLC2A1	metacluster_22.36	BACH2 (directAnnotation).
SLC2A1	metacluster_155.3	PLAG1 (directAnnotation). PLAG1 (inferredBy_Orthology).
SLC2A1	metacluster_22.17	NFE2 (directAnnotation).
SLC2A1	transfac_pro__M06907	ZFP3 (inferredBy_Orthology).
SLC2A1	metacluster_23.5	WT1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
SLC2A1	"Carboxymethylcellulose"	DB11059	small molecule
SLC2A1	"Resveratrol"	DB02709	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."