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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SLC25A40

Summary for SLC25A40

Gene information	Gene symbol	SLC25A40
	Ensembl ID	ENSG00000075303
	Entrez ID	55972
	Gene name	solute carrier family 25 member 40
	Synonyms	MCFP
	Gene type	protein_coding
	UniProtAcc	Q8TBP6

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Dataset with differentially expressed gene: SLC25A40

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	3.05821	3.30e-03

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Expression of SLC25A40 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SLC25A40

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SLC25A40

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SLC25A40	hsa-miR-5011-5p	98.169	NM_018843
SLC25A40	hsa-miR-494-3p	96.3751	NM_018843
SLC25A40	hsa-miR-1-5p	96.1337	NM_018843
SLC25A40	hsa-miR-3685	95.4431	NM_018843
SLC25A40	hsa-miR-12123	94.9955	NM_018843
SLC25A40	hsa-miR-218-2-3p	93.5692	NM_018843
SLC25A40	hsa-miR-4289	93.226	NM_018843
SLC25A40	hsa-miR-4282	92.8999	NM_018843
SLC25A40	hsa-miR-190a-3p	91.9231	NM_018843
SLC25A40	hsa-miR-4684-3p	90.9689	NM_018843
SLC25A40	hsa-miR-548c-3p	90.5967	NM_018843
SLC25A40	hsa-miR-4473	88.7559	NM_018843
SLC25A40	hsa-miR-1277-5p	87.9367	NM_018843
SLC25A40	hsa-miR-664a-3p	87.8776	NM_018843
SLC25A40	hsa-miR-3201	85.9213	NM_018843
SLC25A40	hsa-miR-200a-5p	85.8537	NM_018843
SLC25A40	hsa-miR-200b-5p	85.8537	NM_018843
SLC25A40	hsa-miR-5089-3p	84.3775	NM_018843
SLC25A40	hsa-miR-10523-5p	84.2957	NM_018843
SLC25A40	hsa-miR-4791	83.7635	NM_018843
SLC25A40	hsa-miR-4781-3p	81.3255	NM_018843
SLC25A40	hsa-miR-183-3p	81.2102	NM_018843
SLC25A40	hsa-miR-5680	80.4173	NM_018843
SLC25A40	hsa-miR-7978	80.3354	NM_018843

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Motifs and transcription factors (TFs) regulating SLC25A40

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SLC25A40	hdpi__HIP2	UBE2K (directAnnotation).
SLC25A40	transfac_pro__M04893	TAF1 (directAnnotation).
SLC25A40	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
SLC25A40	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."