Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: SLC1A5

Summary for SLC1A5

Gene information	Gene symbol	SLC1A5
	Ensembl ID	ENSG00000105281
	Entrez ID	6510
	Gene name	solute carrier family 1 member 5
	Synonyms	AAAT\|ASCT2\|M7V1\|RDRC
	Gene type	protein_coding
	UniProtAcc	Q15758

Top

Dataset with differentially expressed gene: SLC1A5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.333219	3.61e-21
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.588358	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	NK cells	-0.511415	8.27e-06
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	0.392056	7.68e-07
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.733829	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.512509	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.281017	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-0.658871	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	-0.460389	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.538823	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.468599	0.00e+00

Top

Expression of SLC1A5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to SLC1A5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating SLC1A5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SLC1A5	hsa-miR-8485	99.9916	NM_001145144
SLC1A5	hsa-miR-6810-5p	96.1012	NM_001145144
SLC1A5	hsa-miR-137-3p	95.6851	NM_001145144
SLC1A5	hsa-miR-6797-5p	92.5913	NM_001145144
SLC1A5	hsa-miR-6852-3p	91.9021	NM_001145144
SLC1A5	hsa-miR-1249-5p	91.723	NM_001145144
SLC1A5	hsa-miR-4652-3p	91.0346	NM_001145144
SLC1A5	hsa-miR-3909	86.4814	NM_001145144
SLC1A5	hsa-miR-1287-3p	86.4136	NM_001145144

Page: 1

Top

Motifs and transcription factors (TFs) regulating SLC1A5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SLC1A5	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
SLC1A5	kznf__PRDM1_modENCODE.2_ChIP-seq	PRDM1 (directAnnotation).
SLC1A5	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
SLC1A5	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
SLC1A5	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
SLC1A5	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
SLC1A5	transfac_pro__M04826	EP300 (directAnnotation).
SLC1A5	cisbp__M02645	ETS1 (directAnnotation).
SLC1A5	hdpi__ETV4	ETV4 (directAnnotation).
SLC1A5	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
SLC1A5	metacluster_156.2	ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
SLC1A5	hdpi__FLI1	FLI1 (directAnnotation).
SLC1A5	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
SLC1A5	taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAP	ATF4; CEBPD (directAnnotation).
SLC1A5	metacluster_22.29	NFE2 (directAnnotation).
SLC1A5	transfac_pro__M05605	GATA6 (inferredBy_Orthology).
SLC1A5	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
SLC1A5	metacluster_30.4	BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).
SLC1A5	metacluster_22.25	NFE2L2 (directAnnotation).
SLC1A5	transfac_pro__M06292	ZNF766 (directAnnotation).
SLC1A5	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
SLC1A5	transfac_pro__M05965	ZNF175 (directAnnotation).
SLC1A5	transfac_pro__M05768	ZNF544 (directAnnotation).
SLC1A5	transfac_pro__M05421	MYNN (inferredBy_Orthology).
SLC1A5	metacluster_178.17	ZNF775 (directAnnotation).
SLC1A5	kznf__ZNF26_Imbeault2017_OM_MEME	ZNF26 (directAnnotation).
SLC1A5	transfac_pro__M06032	ZNF727 (directAnnotation).
SLC1A5	metacluster_22.37	BACH1 (directAnnotation).
SLC1A5	metacluster_152.2	TWIST1 (directAnnotation).
SLC1A5	metacluster_22.30	NFE2L2 (directAnnotation).
SLC1A5	transfac_pro__M06537	CTCFL (directAnnotation).
SLC1A5	metacluster_157.2	ATF3; ATF3; ATF3; BACH1; BACH1; BACH1; BACH2; BACH2; BACH2; BACH2; BATF; BATF; BCL11A; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; MAF; MAFB; MAFF; MAFG; MAFK; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2; NFE2L3; ZNF3; ZSCAN5C (directAnnotation). FOSL1; JUN; JUN; JUN; JUNB; JUNB; JUND (inferredBy_Orthology).
SLC1A5	transfac_pro__M06592	ZNF486 (directAnnotation).
SLC1A5	transfac_pro__M06661	ZNF426 (directAnnotation).
SLC1A5	taipale_cyt_meth__KLF3_NRCCGCAGCCCN_FL_meth_repr	KLF3 (directAnnotation).
SLC1A5	metacluster_137.1	NFE2L1; NFE2L1; ZNF177 (directAnnotation).
SLC1A5	transfac_pro__M05702	ZNF20 (directAnnotation).
SLC1A5	metacluster_22.36	BACH2 (directAnnotation).
SLC1A5	transfac_pro__M06184	ZNF85 (directAnnotation).
SLC1A5	kznf__ZNF343_Imbeault2017_OM_RCADE	ZNF343 (directAnnotation).
SLC1A5	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
SLC1A5	swissregulon__hs__ELF2	ELF2 (directAnnotation).
SLC1A5	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
SLC1A5	transfac_public__M00041	ATF2; JUN (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
SLC1A5	"Asparagine"	DB00174	small molecule
SLC1A5	"Fluciclovine (18F)"	DB13146	small molecule

Page: 1

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."