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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SLC19A2

Summary for SLC19A2

Gene information	Gene symbol	SLC19A2
	Ensembl ID	ENSG00000117479
	Entrez ID	10560
	Gene name	solute carrier family 19 member 2
	Synonyms	ThT1\|THTR1\|TRMA
	Gene type	protein_coding
	UniProtAcc	O60779

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Dataset with differentially expressed gene: SLC19A2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.311983	1.82e-13

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Expression of SLC19A2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SLC19A2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SLC19A2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SLC19A2	hsa-miR-12136	98.4416	NM_001319667
SLC19A2	hsa-miR-3714	95.8445	NM_001319667
SLC19A2	hsa-miR-205-5p	94.1847	NM_006996
SLC19A2	hsa-miR-4755-5p	93.5793	NM_006996
SLC19A2	hsa-miR-5006-3p	93.5793	NM_006996
SLC19A2	hsa-miR-1284	93.4988	NM_006996
SLC19A2	hsa-miR-4799-5p	93.0408	NM_001319667
SLC19A2	hsa-miR-1297	92.9011	NM_001319667
SLC19A2	hsa-miR-5585-3p	92.7823	NM_001319667
SLC19A2	hsa-miR-26b-5p	92.4701	NM_001319667
SLC19A2	hsa-miR-26a-5p	92.4701	NM_001319667
SLC19A2	hsa-miR-6828-5p	92.257	NM_001319667
SLC19A2	hsa-miR-6719-3p	91.7046	NM_001319667
SLC19A2	hsa-miR-10527-5p	91.6465	NM_006996
SLC19A2	hsa-miR-4465	91.5361	NM_001319667
SLC19A2	hsa-miR-3529-3p	91.3264	NM_006996
SLC19A2	hsa-miR-5692a	90.9952	NM_001319667
SLC19A2	hsa-miR-633	90.535	NM_006996
SLC19A2	hsa-miR-3678-3p	90.4619	NM_001319667
SLC19A2	hsa-miR-101-3p	88.4659	NM_001319667
SLC19A2	hsa-miR-1279	88.0793	NM_006996
SLC19A2	hsa-miR-5680	87.9905	NM_006996
SLC19A2	hsa-miR-7-2-3p	87.5923	NM_001319667
SLC19A2	hsa-miR-330-3p	87.5744	NM_006996
SLC19A2	hsa-miR-4794	87.223	NM_006996
SLC19A2	hsa-miR-548ai	87.1453	NM_006996
SLC19A2	hsa-miR-570-5p	87.1453	NM_006996
SLC19A2	hsa-miR-5196-5p	86.9438	NM_001319667
SLC19A2	hsa-miR-4747-5p	86.9438	NM_001319667
SLC19A2	hsa-miR-548c-3p	86.712	NM_001319667
SLC19A2	hsa-miR-548x-3p	85.5473	NM_006996
SLC19A2	hsa-miR-548aj-3p	85.5473	NM_006996
SLC19A2	hsa-miR-664a-5p	85.3408	NM_006996
SLC19A2	hsa-miR-335-3p	84.8474	NM_001319667
SLC19A2	hsa-miR-7-1-3p	84.0989	NM_001319667
SLC19A2	hsa-miR-200a-3p	83.3055	NM_006996
SLC19A2	hsa-miR-141-3p	83.3055	NM_006996
SLC19A2	hsa-miR-548p	83.3022	NM_006996
SLC19A2	hsa-miR-548ah-3p	83.2983	NM_006996
SLC19A2	hsa-miR-548aq-3p	83.2983	NM_006996
SLC19A2	hsa-miR-548j-3p	83.2983	NM_006996
SLC19A2	hsa-miR-548ae-3p	83.2983	NM_006996
SLC19A2	hsa-miR-548am-3p	83.2983	NM_006996
SLC19A2	hsa-miR-5697	83.0955	NM_001319667
SLC19A2	hsa-miR-3163	82.5459	NM_001319667
SLC19A2	hsa-miR-5007-3p	82.493	NM_006996
SLC19A2	hsa-miR-9-5p	81.9356	NM_001319667
SLC19A2	hsa-miR-126-5p	80.7243	NM_006996
SLC19A2	hsa-miR-330-5p	80.3519	NM_006996

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Motifs and transcription factors (TFs) regulating SLC19A2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SLC19A2	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."