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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: SLC16A6

Summary for SLC16A6

Gene information	Gene symbol	SLC16A6
	Ensembl ID	ENSG00000108932
	Entrez ID	9120
	Gene name	solute carrier family 16 member 6
	Synonyms	MCT6\|MCT7
	Gene type	protein_coding
	UniProtAcc	O15403

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Dataset with differentially expressed gene: SLC16A6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-1.00036	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.519575	0.00e+00

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Expression of SLC16A6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SLC16A6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SLC16A6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SLC16A6	hsa-miR-5011-5p	99.6444	NM_001174166
SLC16A6	hsa-miR-190a-3p	99.6156	NM_001174166
SLC16A6	hsa-miR-3190-5p	97.4674	NM_001174166
SLC16A6	hsa-miR-204-5p	97.2113	NM_001174166
SLC16A6	hsa-miR-211-5p	97.2113	NM_001174166
SLC16A6	hsa-miR-889-5p	96.9254	NM_001174166
SLC16A6	hsa-miR-5006-3p	96.3015	NM_001174166
SLC16A6	hsa-miR-4755-5p	96.3015	NM_001174166
SLC16A6	hsa-miR-1297	94.9825	NM_001174166
SLC16A6	hsa-miR-26a-5p	94.021	NM_001174166
SLC16A6	hsa-miR-26b-5p	94.021	NM_001174166
SLC16A6	hsa-miR-548p	93.8575	NM_001174166
SLC16A6	hsa-miR-4465	93.4799	NM_001174166
SLC16A6	hsa-miR-543	93.3513	NM_001174166
SLC16A6	hsa-miR-623	92.925	NM_001174166
SLC16A6	hsa-miR-3938	92.6114	NM_001174166
SLC16A6	hsa-miR-4316	92.6034	NM_001174166
SLC16A6	hsa-miR-6081	92.4794	NM_001174166
SLC16A6	hsa-miR-512-3p	92.0549	NM_001174166
SLC16A6	hsa-miR-135b-5p	90.6855	NM_001174166
SLC16A6	hsa-miR-135a-5p	90.6855	NM_001174166
SLC16A6	hsa-miR-20a-5p	90.3146	NM_001174166
SLC16A6	hsa-miR-106b-5p	90.3146	NM_001174166
SLC16A6	hsa-miR-526b-3p	89.1435	NM_001174166
SLC16A6	hsa-miR-17-5p	89.1435	NM_001174166
SLC16A6	hsa-miR-93-5p	89.1435	NM_001174166
SLC16A6	hsa-miR-106a-5p	89.1435	NM_001174166
SLC16A6	hsa-miR-519d-3p	89.1435	NM_001174166
SLC16A6	hsa-miR-20b-5p	89.1435	NM_001174166
SLC16A6	hsa-miR-6832-3p	89.0804	NM_001174166
SLC16A6	hsa-miR-193a-3p	88.923	NM_001174166
SLC16A6	hsa-miR-193b-3p	88.923	NM_001174166
SLC16A6	hsa-miR-506-5p	88.5302	NM_001174166
SLC16A6	hsa-miR-4668-3p	87.9957	NM_001174166
SLC16A6	hsa-miR-2052	87.0366	NM_001174166
SLC16A6	hsa-miR-12123	86.8282	NM_001174166
SLC16A6	hsa-miR-3679-3p	86.3994	NM_001174166
SLC16A6	hsa-miR-23a-3p	85.3628	NM_001174166
SLC16A6	hsa-miR-23c	85.3628	NM_001174166
SLC16A6	hsa-miR-23b-3p	85.3628	NM_001174166
SLC16A6	hsa-miR-3678-3p	84.7176	NM_001174166
SLC16A6	hsa-miR-146a-3p	84.5177	NM_001174166
SLC16A6	hsa-miR-4796-3p	84.2086	NM_001174166
SLC16A6	hsa-miR-148b-3p	83.6261	NM_001174166
SLC16A6	hsa-miR-148a-3p	83.6261	NM_001174166
SLC16A6	hsa-miR-152-3p	83.6261	NM_001174166
SLC16A6	hsa-miR-4319	82.8886	NM_001174166
SLC16A6	hsa-miR-302a-3p	82.3342	NM_001174166
SLC16A6	hsa-miR-302c-3p	82.3342	NM_001174166
SLC16A6	hsa-miR-302e	82.3342	NM_001174166

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Motifs and transcription factors (TFs) regulating SLC16A6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SLC16A6	metacluster_151.2	ZNF23 (directAnnotation).
SLC16A6	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SLC16A6	hdpi__ETV4	ETV4 (directAnnotation).
SLC16A6	transfac_pro__M04916	TAF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
SLC16A6	"Pyruvic acid"	DB00119	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."