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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SLC16A10

Summary for SLC16A10

Gene information	Gene symbol	SLC16A10
	Ensembl ID	ENSG00000112394
	Entrez ID	117247
	Gene name	solute carrier family 16 member 10
	Synonyms	MCT10\|TAT1
	Gene type	protein_coding
	UniProtAcc	Q8TF71

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Dataset with differentially expressed gene: SLC16A10

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.459693	1.18e-06
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.380556	8.12e-08

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Expression of SLC16A10 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SLC16A10

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SLC16A10

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SLC16A10	hsa-miR-4794	95.2344	NM_018593
SLC16A10	hsa-miR-664a-5p	95.1923	NM_018593
SLC16A10	hsa-miR-4756-3p	93.9294	NM_018593
SLC16A10	hsa-miR-548p	93.1582	NM_018593
SLC16A10	hsa-miR-450b-5p	92.9798	NM_018593
SLC16A10	hsa-miR-4719	90.4642	NM_018593
SLC16A10	hsa-miR-5571-3p	89.5584	NM_018593
SLC16A10	hsa-miR-5690	89.3265	NM_018593
SLC16A10	hsa-miR-4659b-3p	88.7667	NM_018593
SLC16A10	hsa-miR-4659a-3p	88.7667	NM_018593
SLC16A10	hsa-miR-302e	88.2624	NM_018593
SLC16A10	hsa-miR-5692a	88.1759	NM_018593
SLC16A10	hsa-miR-5701	86.6076	NM_018593
SLC16A10	hsa-miR-202-3p	86.4098	NM_018593
SLC16A10	hsa-miR-1299	85.907	NM_018593
SLC16A10	hsa-miR-520a-3p	84.5472	NM_018593
SLC16A10	hsa-miR-520c-3p	84.5472	NM_018593
SLC16A10	hsa-miR-520b-3p	84.5472	NM_018593
SLC16A10	hsa-miR-520e-3p	84.5472	NM_018593
SLC16A10	hsa-miR-302c-3p	84.2249	NM_018593
SLC16A10	hsa-miR-302d-3p	84.2249	NM_018593
SLC16A10	hsa-miR-302b-3p	84.2249	NM_018593
SLC16A10	hsa-miR-302a-3p	84.2249	NM_018593
SLC16A10	hsa-miR-9985	83.6607	NM_018593
SLC16A10	hsa-miR-218-5p	82.9761	NM_018593
SLC16A10	hsa-miR-568	82.8547	NM_018593
SLC16A10	hsa-miR-4764-5p	82.7973	NM_018593
SLC16A10	hsa-miR-5688	82.6054	NM_018593
SLC16A10	hsa-miR-4503	82.175	NM_018593
SLC16A10	hsa-miR-495-3p	80.4609	NM_018593

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Motifs and transcription factors (TFs) regulating SLC16A10

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SLC16A10	jaspar__MA1106.1	HIF1A (directAnnotation).
SLC16A10	metacluster_119.2	CCNT2; GATA1; GATA1; GATA1; GATA1; GATA2; GATA2; GATA2; NCOA1; TAL1; TAL1; TAL1; TAL1; ZNF823 (directAnnotation). GATA1; TAL1; TAL1; TAL1; TAL1 (inferredBy_Orthology).
SLC16A10	dbtfbs__ZNF664_HEK293_ENCSR714LZQ_merged_N1	ZNF664 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."