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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SLC12A8

Summary for SLC12A8

Gene information	Gene symbol	SLC12A8
	Ensembl ID	ENSG00000221955
	Entrez ID	84561
	Gene name	solute carrier family 12 member 8
	Synonyms	CCC9
	Gene type	protein_coding
	UniProtAcc	A0AV02

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Dataset with differentially expressed gene: SLC12A8

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.933081	3.63e-02
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.386979	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.521586	0.00e+00

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Expression of SLC12A8 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SLC12A8

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SLC12A8

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SLC12A8	hsa-miR-5695	93.064	NM_001195483
SLC12A8	hsa-miR-548f-5p	92.6154	NM_001195483
SLC12A8	hsa-miR-548aj-5p	92.6154	NM_001195483
SLC12A8	hsa-miR-548x-5p	92.6154	NM_001195483
SLC12A8	hsa-miR-548g-5p	92.6154	NM_001195483
SLC12A8	hsa-miR-4455	90.4284	NM_001195483
SLC12A8	hsa-miR-549a-5p	89.1373	NM_001195483
SLC12A8	hsa-miR-10523-5p	88.7251	NM_001195483
SLC12A8	hsa-miR-3925-3p	87.8354	NM_001195483
SLC12A8	hsa-miR-6736-3p	86.8125	NM_001195483
SLC12A8	hsa-miR-3613-3p	85.5568	NM_001195483
SLC12A8	hsa-miR-4666a-3p	85.5507	NM_001195483
SLC12A8	hsa-miR-5584-5p	85.3453	NM_001195483
SLC12A8	hsa-miR-6892-5p	85.1313	NM_001195483
SLC12A8	hsa-miR-5692a	84.4654	NM_001195483
SLC12A8	hsa-miR-616-5p	84.044	NM_001195483
SLC12A8	hsa-miR-371b-5p	84.044	NM_001195483
SLC12A8	hsa-miR-373-5p	84.044	NM_001195483
SLC12A8	hsa-miR-519d-5p	83.7038	NM_001195483
SLC12A8	hsa-miR-5010-3p	83.5822	NM_001195483
SLC12A8	hsa-miR-450a-1-3p	83.5697	NM_001195483
SLC12A8	hsa-miR-6794-3p	82.8976	NM_001195483
SLC12A8	hsa-miR-219a-5p	81.6953	NM_001195483
SLC12A8	hsa-miR-4782-3p	81.6953	NM_001195483
SLC12A8	hsa-miR-6766-3p	81.6953	NM_001195483
SLC12A8	hsa-miR-4531	81.2822	NM_001195483

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Motifs and transcription factors (TFs) regulating SLC12A8

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SLC12A8	taipale_tf_pairs__ETV2_DLX3_RSCGGAANNNNNNNTAATKR_CAP_repr	DLX3; ETV2 (directAnnotation).
SLC12A8	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
SLC12A8	transfac_pro__M05838	ZNF550 (directAnnotation).
SLC12A8	transfac_pro__M01299	MECP2 (directAnnotation).
SLC12A8	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
SLC12A8	jaspar__MA1708.1	ETV7 (directAnnotation).
SLC12A8	metacluster_15.4	SMAD6 (directAnnotation). SMAD6 (inferredBy_Orthology).
SLC12A8	taipale_tf_pairs__HOXB2_ELK1_TAATKRCCGGAAGNN_CAP_repr	ELK1; HOXB2 (directAnnotation).
SLC12A8	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
SLC12A8	taipale_tf_pairs__POU2F1_ETV1_NCCGGATATGCAN_CAP_repr	ETV1; POU2F1 (directAnnotation).
SLC12A8	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP_repr	ERG; TEAD4 (directAnnotation).
SLC12A8	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."