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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SLAMF8

Summary for SLAMF8

Gene information	Gene symbol	SLAMF8
	Ensembl ID	ENSG00000158714
	Entrez ID	56833
	Gene name	SLAM family member 8
	Synonyms	BLAME\|CD353\|SBBI42
	Gene type	protein_coding
	UniProtAcc	Q9P0V8

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Dataset with differentially expressed gene: SLAMF8

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	-0.468227	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.267442	2.87e-03
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.452465	1.87e-08

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Expression of SLAMF8 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SLAMF8

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SLAMF8

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SLAMF8	hsa-miR-4471	90.3237	NM_020125
SLAMF8	hsa-miR-4673	89.0362	NM_020125
SLAMF8	hsa-miR-8059	87.1932	NM_020125
SLAMF8	hsa-miR-92a-2-5p	86.3653	NM_020125
SLAMF8	hsa-miR-4645-5p	85.0992	NM_020125
SLAMF8	hsa-miR-4751	81.0197	NM_020125
SLAMF8	hsa-miR-1275	80.0977	NM_020125

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Motifs and transcription factors (TFs) regulating SLAMF8

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SLAMF8	transfac_pro__M01239	RELA (directAnnotation).
SLAMF8	transfac_pro__M05464	SALL1 (directAnnotation).
SLAMF8	transfac_pro__M04706	RELA (directAnnotation).
SLAMF8	tfdimers__MD00007	E2F1; IRF8 (directAnnotation).
SLAMF8	transfac_pro__M06764	ZNF112 (directAnnotation).
SLAMF8	tfdimers__MD00056	EP300; ZEB1 (directAnnotation).
SLAMF8	metacluster_22.21	NFE2L2 (inferredBy_Orthology).
SLAMF8	transfac_pro__M04699	MAFK (directAnnotation).
SLAMF8	transfac_pro__M01069	GZF1 (directAnnotation).
SLAMF8	transfac_pro__M04849	RELA (directAnnotation).
SLAMF8	transfac_pro__M06807	SALL2 (inferredBy_Orthology).
SLAMF8	taipale_tf_pairs__TEAD4_ETV4_RCCGGAAATRCC_CAP	ETV4; TEAD4 (directAnnotation).
SLAMF8	transfac_pro__M06573	ZNF419 (directAnnotation).
SLAMF8	metacluster_172.27	DMRTC2 (directAnnotation).
SLAMF8	jaspar__MA1125.1	ZNF384 (directAnnotation).
SLAMF8	transfac_pro__M05985	ZNF394 (inferredBy_Orthology).
SLAMF8	kznf__ZNF675_Najafabadi2015_ChIP-seq	ZNF675 (directAnnotation).
SLAMF8	taipale_tf_pairs__HOXB13_TBX21_ARGTGNNNNNNATAAA_CAP_repr	HOXB13; TBX21 (directAnnotation).
SLAMF8	transfac_pro__M05613	ZNF35 (directAnnotation).
SLAMF8	tfdimers__MD00208	IRF1; LTF (directAnnotation).
SLAMF8	metacluster_12.1	ZNF3 (directAnnotation).
SLAMF8	transfac_pro__M06070	ZNF732 (directAnnotation).
SLAMF8	transfac_pro__M06398	ZNF761 (directAnnotation).
SLAMF8	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_1	SPIB; TEAD4 (directAnnotation).
SLAMF8	tfdimers__MD00295	EBF1; STAT6 (directAnnotation).
SLAMF8	tfdimers__MD00433	NKX3-2; ZNF217 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."