Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SLAIN2

Summary for SLAIN2

Gene information	Gene symbol	SLAIN2
	Ensembl ID	ENSG00000109171
	Entrez ID	57606
	Gene name	SLAIN motif family member 2
	Synonyms	FLJ21611\|KIAA1458
	Gene type	protein_coding
	UniProtAcc	Q9P270

Top

Dataset with differentially expressed gene: SLAIN2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	B cells	-0.38837	5.97e-04
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.31352	3.92e-44

Top

Expression of SLAIN2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to SLAIN2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating SLAIN2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SLAIN2	hsa-miR-548az-5p	99.3543	NM_020846
SLAIN2	hsa-miR-548t-5p	99.3543	NM_020846
SLAIN2	hsa-let-7c-3p	99.2652	NM_020846
SLAIN2	hsa-miR-6809-3p	98.6661	NM_020846
SLAIN2	hsa-miR-96-5p	97.8991	NM_020846
SLAIN2	hsa-miR-545-5p	97.6112	NM_020846
SLAIN2	hsa-miR-6833-3p	97.5095	NM_020846
SLAIN2	hsa-miR-3124-3p	97.327	NM_020846
SLAIN2	hsa-miR-1271-5p	97.2742	NM_020846
SLAIN2	hsa-miR-12133	97.2742	NM_020846
SLAIN2	hsa-miR-548n	96.7011	NM_020846
SLAIN2	hsa-miR-4262	96.6415	NM_020846
SLAIN2	hsa-let-7a-3p	96.5285	NM_020846
SLAIN2	hsa-miR-98-3p	96.5285	NM_020846
SLAIN2	hsa-let-7b-3p	96.5285	NM_020846
SLAIN2	hsa-let-7f-1-3p	96.5285	NM_020846
SLAIN2	hsa-miR-3658	96.4215	NM_020846
SLAIN2	hsa-miR-4753-3p	96.28	NM_020846
SLAIN2	hsa-miR-4768-5p	95.9521	NM_020846
SLAIN2	hsa-miR-20a-3p	95.1528	NM_020846
SLAIN2	hsa-miR-548aw	94.8588	NM_020846
SLAIN2	hsa-miR-7110-3p	94.8132	NM_020846
SLAIN2	hsa-miR-302e	94.5939	NM_020846
SLAIN2	hsa-miR-300	94.5366	NM_020846
SLAIN2	hsa-miR-381-3p	94.5366	NM_020846
SLAIN2	hsa-miR-548ah-5p	94.5208	NM_020846
SLAIN2	hsa-miR-3609	94.5208	NM_020846
SLAIN2	hsa-miR-181c-5p	94.4234	NM_020846
SLAIN2	hsa-miR-181d-5p	94.4234	NM_020846
SLAIN2	hsa-miR-181b-5p	94.4234	NM_020846
SLAIN2	hsa-miR-181a-5p	94.4234	NM_020846
SLAIN2	hsa-miR-101-3p	93.9575	NM_020846
SLAIN2	hsa-miR-493-5p	93.8383	NM_020846
SLAIN2	hsa-miR-3674	93.7021	NM_020846
SLAIN2	hsa-miR-4307	93.6356	NM_020846
SLAIN2	hsa-miR-5692a	93.1236	NM_020846
SLAIN2	hsa-miR-106b-5p	93.0975	NM_020846
SLAIN2	hsa-miR-20a-5p	93.0975	NM_020846
SLAIN2	hsa-miR-6071	92.9939	NM_020846
SLAIN2	hsa-miR-520e-3p	92.9865	NM_020846
SLAIN2	hsa-miR-373-3p	92.9865	NM_020846
SLAIN2	hsa-miR-6507-5p	92.9029	NM_020846
SLAIN2	hsa-miR-2681-5p	92.8993	NM_020846
SLAIN2	hsa-miR-302d-3p	92.879	NM_020846
SLAIN2	hsa-miR-302a-3p	92.879	NM_020846
SLAIN2	hsa-miR-302c-3p	92.879	NM_020846
SLAIN2	hsa-miR-302b-3p	92.879	NM_020846
SLAIN2	hsa-miR-144-3p	92.7368	NM_020846
SLAIN2	hsa-miR-1323	92.5	NM_020846
SLAIN2	hsa-miR-218-5p	92.3151	NM_020846

Page: 1 2 3

Top

Motifs and transcription factors (TFs) regulating SLAIN2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SLAIN2	metacluster_7.13	ZFX (directAnnotation).
SLAIN2	cisbp__M01863	ZNF711 (inferredBy_Orthology).
SLAIN2	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
SLAIN2	metacluster_151.2	ZNF23 (directAnnotation).
SLAIN2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
SLAIN2	transfac_pro__M05479	ZNF580 (directAnnotation).
SLAIN2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SLAIN2	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
SLAIN2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SLAIN2	hdpi__ETV4	ETV4 (directAnnotation).
SLAIN2	jaspar__MA0748.2	YY2 (directAnnotation).
SLAIN2	transfac_pro__M05628	ZNF735 (directAnnotation).
SLAIN2	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
SLAIN2	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
SLAIN2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SLAIN2	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
SLAIN2	jaspar__MA1933.1	SREBF2 (directAnnotation).
SLAIN2	jaspar__MA0079.5	SP1 (directAnnotation).
SLAIN2	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
SLAIN2	metacluster_107.1	CERS2; CERS3; CERS4; CERS5; CERS6 (inferredBy_Orthology).
SLAIN2	metacluster_168.18	ZNF214; ZNF239; ZNF45; ZNF696 (directAnnotation).
SLAIN2	transfac_pro__M05858	ZNF625 (directAnnotation).
SLAIN2	dbtfbs__ZFP91_K562_ENCSR898XMH_merged_N1	ZFP91 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."