Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SKI

Summary for SKI

Gene information	Gene symbol	SKI
	Ensembl ID	ENSG00000157933
	Entrez ID	6497
	Gene name	SKI proto-oncogene
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P12755

Top

Dataset with differentially expressed gene: SKI

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.490956	1.92e-40
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.255248	2.22e-15

Top

Expression of SKI in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to SKI

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating SKI

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SKI	hsa-miR-3680-3p	99.169	NM_003036
SKI	hsa-miR-5006-3p	98.7317	NM_003036
SKI	hsa-miR-4755-5p	98.7317	NM_003036
SKI	hsa-miR-623	98.0742	NM_003036
SKI	hsa-miR-4729	97.9006	NM_003036
SKI	hsa-miR-3121-3p	97.2989	NM_003036
SKI	hsa-miR-4742-5p	96.176	NM_003036
SKI	hsa-miR-4692	95.4399	NM_003036
SKI	hsa-miR-6780b-3p	95.4337	NM_003036
SKI	hsa-miR-4446-5p	95.4048	NM_003036
SKI	hsa-miR-4739	95.2517	NM_003036
SKI	hsa-miR-548h-3p	95.1111	NM_003036
SKI	hsa-miR-548z	95.1111	NM_003036
SKI	hsa-miR-548ac	95.1111	NM_003036
SKI	hsa-miR-548d-3p	95.1111	NM_003036
SKI	hsa-miR-548bb-3p	95.1111	NM_003036
SKI	hsa-miR-4447	94.8094	NM_003036
SKI	hsa-miR-1321	94.663	NM_003036
SKI	hsa-miR-4756-5p	94.663	NM_003036
SKI	hsa-miR-590-5p	94.5123	NM_003036
SKI	hsa-miR-21-5p	94.043	NM_003036
SKI	hsa-miR-6715b-5p	93.8503	NM_003036
SKI	hsa-miR-4514	93.8503	NM_003036
SKI	hsa-miR-4269	93.8503	NM_003036
SKI	hsa-miR-211-5p	93.5324	NM_003036
SKI	hsa-miR-204-5p	93.5324	NM_003036
SKI	hsa-miR-4780	92.6377	NM_003036
SKI	hsa-miR-92a-2-5p	91.852	NM_003036
SKI	hsa-miR-5579-3p	91.2186	NM_003036
SKI	hsa-miR-6756-5p	90.9177	NM_003036
SKI	hsa-miR-328-5p	90.8621	NM_003036
SKI	hsa-miR-498-5p	90.8349	NM_003036
SKI	hsa-miR-548c-3p	89.86	NM_003036
SKI	hsa-miR-4441	89.6439	NM_003036
SKI	hsa-miR-6766-5p	89.3861	NM_003036
SKI	hsa-miR-15b-5p	89.3192	NM_003036
SKI	hsa-miR-195-5p	89.3192	NM_003036
SKI	hsa-miR-16-5p	89.3192	NM_003036
SKI	hsa-miR-15a-5p	89.3192	NM_003036
SKI	hsa-miR-6885-5p	89.2426	NM_003036
SKI	hsa-miR-6838-5p	89.11	NM_003036
SKI	hsa-miR-3168	87.9316	NM_003036
SKI	hsa-miR-552-3p	87.8667	NM_003036
SKI	hsa-miR-6505-5p	87.7014	NM_003036
SKI	hsa-miR-635	87.5662	NM_003036
SKI	hsa-miR-4270	86.801	NM_003036
SKI	hsa-miR-4435	86.5722	NM_003036
SKI	hsa-miR-6776-5p	85.8294	NM_003036
SKI	hsa-miR-6774-5p	85.6405	NM_003036
SKI	hsa-miR-2467-3p	85.4402	NM_003036

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating SKI

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SKI	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
SKI	cisbp__M01815	CEBPE (inferredBy_Orthology).
SKI	metacluster_157.2	ATF3; ATF3; ATF3; BACH1; BACH1; BACH1; BACH2; BACH2; BACH2; BACH2; BATF; BATF; BCL11A; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; MAF; MAFB; MAFF; MAFG; MAFK; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2; NFE2L3; ZNF3; ZSCAN5C (directAnnotation). FOSL1; JUN; JUN; JUN; JUNB; JUNB; JUND (inferredBy_Orthology).
SKI	metacluster_137.2	ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
SKI	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
SKI	metacluster_111.5	E4F1; E4F1 (directAnnotation).
SKI	transfac_pro__M01253	CNOT3 (directAnnotation).
SKI	metacluster_153.4	SOX12; SOX14; SRY (directAnnotation). SOX5 (inferredBy_Orthology).
SKI	transfac_pro__M04817	ZBTB33 (directAnnotation).
SKI	transfac_pro__M02896	SPI1 (inferredBy_Orthology).
SKI	transfac_pro__M05712	ZNF134 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."