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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SIPA1L1

Summary for SIPA1L1

Gene information	Gene symbol	SIPA1L1
	Ensembl ID	ENSG00000197555
	Entrez ID	26037
	Gene name	signal induced proliferation associated 1 like 1
	Synonyms	E6TP1\|KIAA0440\|SPAR1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SIPA1L1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.581883	1.65e-02

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Expression of SIPA1L1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SIPA1L1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SIPA1L1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SIPA1L1	hsa-miR-548aw	97.5334	NM_001284245
SIPA1L1	hsa-miR-19a-3p	96.2337	NM_001284247
SIPA1L1	hsa-miR-19b-3p	96.2337	NM_001284247
SIPA1L1	hsa-miR-627-3p	94.076	NM_001284245
SIPA1L1	hsa-miR-4306	93.8837	NM_001284247
SIPA1L1	hsa-miR-6797-5p	93.5159	NM_001284247
SIPA1L1	hsa-miR-618	93.0495	NM_001284245
SIPA1L1	hsa-miR-205-5p	92.2094	NM_001284245
SIPA1L1	hsa-miR-4703-5p	92.1515	NM_001284245
SIPA1L1	hsa-miR-23a-3p	92.147	NM_001284245
SIPA1L1	hsa-miR-23b-3p	92.147	NM_001284245
SIPA1L1	hsa-miR-23c	92.147	NM_001284245
SIPA1L1	hsa-miR-1249-5p	91.4467	NM_001284247
SIPA1L1	hsa-miR-524-5p	91.2549	NM_001284245
SIPA1L1	hsa-miR-520d-5p	91.2549	NM_001284245
SIPA1L1	hsa-miR-3942-5p	91.2293	NM_001284245
SIPA1L1	hsa-miR-3662	90.2327	NM_001284247
SIPA1L1	hsa-miR-374b-3p	89.5586	NM_001284247
SIPA1L1	hsa-miR-6882-5p	88.3505	NM_001284247
SIPA1L1	hsa-miR-4644	88.2115	NM_001284247
SIPA1L1	hsa-miR-185-5p	88.2115	NM_001284247
SIPA1L1	hsa-miR-1283	87.6806	NM_001284245
SIPA1L1	hsa-miR-4283	87.0689	NM_001284247
SIPA1L1	hsa-miR-6770-5p	86.8996	NM_001284247
SIPA1L1	hsa-miR-4282	86.6367	NM_001284247
SIPA1L1	hsa-miR-605-3p	86.5941	NM_001284245
SIPA1L1	hsa-miR-2276-3p	86.529	NM_001284245
SIPA1L1	hsa-miR-4251	86.4286	NM_001284247
SIPA1L1	hsa-miR-548c-3p	85.5589	NM_001284247
SIPA1L1	hsa-miR-1286	85.0316	NM_001284247
SIPA1L1	hsa-miR-543	83.4179	NM_001284247
SIPA1L1	hsa-miR-4676-3p	83.2905	NM_001284247
SIPA1L1	hsa-miR-892c-3p	83.2905	NM_001284247
SIPA1L1	hsa-miR-452-5p	83.2905	NM_001284247
SIPA1L1	hsa-miR-580-5p	82.6539	NM_001284247
SIPA1L1	hsa-miR-6852-5p	82.482	NM_001284247
SIPA1L1	hsa-miR-4766-3p	81.9489	NM_001284247
SIPA1L1	hsa-miR-6510-5p	81.7764	NM_001284247
SIPA1L1	hsa-miR-4772-3p	81.3616	NM_001284245
SIPA1L1	hsa-miR-3160-5p	81.0643	NM_001284247
SIPA1L1	hsa-miR-1293	80.1558	NM_001284245
SIPA1L1	hsa-miR-4696	80.0352	NM_001284245

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Motifs and transcription factors (TFs) regulating SIPA1L1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."