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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SIKE1

Summary for SIKE1

Gene information	Gene symbol	SIKE1
	Ensembl ID	ENSG00000052723
	Entrez ID	80143
	Gene name	suppressor of IKBKE 1
	Synonyms	FLJ21168\|SIKE
	Gene type	protein_coding
	UniProtAcc	Q9BRV8

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Dataset with differentially expressed gene: SIKE1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.505078	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.556066	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.367248	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.278416	0.00e+00

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Expression of SIKE1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SIKE1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SIKE1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SIKE1	hsa-miR-3121-3p	99.3694	NM_025073
SIKE1	hsa-miR-3613-3p	99.2263	NM_001102396
SIKE1	hsa-miR-372-5p	98.7124	NM_025073
SIKE1	hsa-miR-3924	98.4191	NM_025073
SIKE1	hsa-miR-568	97.299	NM_001102396
SIKE1	hsa-miR-612	95.5727	NM_025073
SIKE1	hsa-miR-6860	95.5727	NM_025073
SIKE1	hsa-miR-3187-5p	95.5727	NM_025073
SIKE1	hsa-miR-1285-3p	95.5141	NM_025073
SIKE1	hsa-miR-5189-5p	95.5141	NM_025073
SIKE1	hsa-miR-3163	93.9683	NM_025073
SIKE1	hsa-miR-371b-5p	93.8767	NM_025073
SIKE1	hsa-miR-373-5p	93.8767	NM_025073
SIKE1	hsa-miR-616-5p	93.8767	NM_025073
SIKE1	hsa-miR-7114-5p	93.4065	NM_025073
SIKE1	hsa-miR-548c-3p	93.3018	NM_001102396
SIKE1	hsa-miR-190a-3p	92.868	NM_025073
SIKE1	hsa-miR-106b-5p	92.3958	NM_025073
SIKE1	hsa-miR-20a-5p	92.3958	NM_025073
SIKE1	hsa-miR-4668-3p	92.2769	NM_025073
SIKE1	hsa-miR-590-3p	91.9854	NM_025073
SIKE1	hsa-miR-577	91.6023	NM_025073
SIKE1	hsa-miR-3133	91.551	NM_025073
SIKE1	hsa-miR-3662	91.4239	NM_025073
SIKE1	hsa-miR-514b-5p	91.1705	NM_001102396
SIKE1	hsa-miR-513c-5p	91.1705	NM_001102396
SIKE1	hsa-miR-6768-5p	91.117	NM_001102396
SIKE1	hsa-miR-10393-5p	90.4527	NM_025073
SIKE1	hsa-miR-7152-5p	90.149	NM_025073
SIKE1	hsa-miR-519d-3p	89.9916	NM_025073
SIKE1	hsa-miR-93-5p	89.9916	NM_025073
SIKE1	hsa-miR-20b-5p	89.9916	NM_025073
SIKE1	hsa-miR-106a-5p	89.9916	NM_025073
SIKE1	hsa-miR-17-5p	89.9916	NM_025073
SIKE1	hsa-miR-526b-3p	89.9916	NM_025073
SIKE1	hsa-miR-4520-2-3p	89.7102	NM_025073
SIKE1	hsa-miR-34c-3p	88.3861	NM_025073
SIKE1	hsa-miR-6835-3p	88.3835	NM_025073
SIKE1	hsa-miR-3148	88.1173	NM_025073
SIKE1	hsa-miR-4282	87.5449	NM_001102396
SIKE1	hsa-miR-10523-5p	87.464	NM_025073
SIKE1	hsa-miR-4495	86.6655	NM_025073
SIKE1	hsa-miR-576-3p	86.6152	NM_001102396
SIKE1	hsa-miR-4310	86.284	NM_025073
SIKE1	hsa-miR-4452	85.6465	NM_025073
SIKE1	hsa-miR-4482-3p	85.3073	NM_025073
SIKE1	hsa-miR-3120-3p	85.2854	NM_025073
SIKE1	hsa-miR-3688-3p	85.2839	NM_025073
SIKE1	hsa-miR-5682	84.2945	NM_001102396
SIKE1	hsa-miR-4762-5p	83.9736	NM_025073

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Motifs and transcription factors (TFs) regulating SIKE1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SIKE1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
SIKE1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
SIKE1	transfac_pro__M04826	EP300 (directAnnotation).
SIKE1	jaspar__MA1933.1	SREBF2 (directAnnotation).
SIKE1	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
SIKE1	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
SIKE1	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
SIKE1	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
SIKE1	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."