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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: SIK1

Summary for SIK1

Gene information	Gene symbol	SIK1
	Ensembl ID	ENSG00000142178
	Entrez ID	150094
	Gene name	salt inducible kinase 1
	Synonyms	msk\|SNF1LK
	Gene type	protein_coding
	UniProtAcc	P57059

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Dataset with differentially expressed gene: SIK1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.282351	1.33e-09
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.556883	1.09e-31

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Expression of SIK1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SIK1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SIK1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SIK1	hsa-miR-8485	98.4363	NM_173354
SIK1	hsa-miR-3119	96.9514	NM_173354
SIK1	hsa-miR-4711-3p	94.0527	NM_173354
SIK1	hsa-miR-137-3p	92.8842	NM_173354
SIK1	hsa-miR-15a-5p	92.8617	NM_173354
SIK1	hsa-miR-148b-3p	91.7541	NM_173354
SIK1	hsa-miR-148a-3p	91.7541	NM_173354
SIK1	hsa-miR-152-3p	91.7541	NM_173354
SIK1	hsa-miR-15b-5p	91.1236	NM_173354
SIK1	hsa-miR-16-5p	91.1236	NM_173354
SIK1	hsa-miR-6838-5p	91.1236	NM_173354
SIK1	hsa-miR-195-5p	91.1236	NM_173354
SIK1	hsa-miR-424-5p	90.5422	NM_173354
SIK1	hsa-miR-497-5p	90.5422	NM_173354
SIK1	hsa-miR-141-3p	85.7181	NM_173354
SIK1	hsa-miR-200a-3p	85.7181	NM_173354
SIK1	hsa-miR-6875-3p	82.6505	NM_173354
SIK1	hsa-miR-548ar-3p	82.2224	NM_173354
SIK1	hsa-miR-9-5p	81.6414	NM_173354
SIK1	hsa-miR-9985	81.0942	NM_173354
SIK1	hsa-miR-27a-3p	81.0942	NM_173354
SIK1	hsa-miR-27b-3p	81.0942	NM_173354
SIK1	hsa-miR-511-5p	80.9603	NM_173354
SIK1	hsa-miR-3977	80.7072	NM_173354

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Motifs and transcription factors (TFs) regulating SIK1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SIK1	hdpi__NFIX	NFIX (directAnnotation).
SIK1	metacluster_153.4	SOX12; SOX14; SRY (directAnnotation). SOX5 (inferredBy_Orthology).
SIK1	transfac_pro__M02896	SPI1 (inferredBy_Orthology).
SIK1	cisbp__M00161	FOXJ1 (inferredBy_Orthology).
SIK1	taipale_tf_pairs__HOXB13_ONECUT2_NNNRTAAAWATYGAYY_CAP	HOXB13; ONECUT2 (directAnnotation).
SIK1	metacluster_134.7	FOXD2; FOXG1; FOXI1; FOXJ2; FOXJ2; FOXJ3; FOXJ3; FOXK1; FOXK1; FOXK2; FOXO4; FOXO6; FOXP2 (directAnnotation). FOXC1; FOXO1; FOXO6 (inferredBy_Orthology).
SIK1	transfac_pro__M07270	TEAD4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
SIK1	"Dabrafenib"	DB08912	small molecule
SIK1	"Fostamatinib"	DB12010	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."