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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SHPRH

Summary for SHPRH

Gene information	Gene symbol	SHPRH
	Ensembl ID	ENSG00000146414
	Entrez ID	257218
	Gene name	SNF2 histone linker PHD RING helicase
	Synonyms	bA545I5.2\|FLJ90837\|KIAA2023
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SHPRH

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.498124	1.20e-02
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.35998	4.82e-28

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Expression of SHPRH in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SHPRH

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SHPRH

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SHPRH	hsa-miR-3163	98.9808	NM_001042683
SHPRH	hsa-miR-498-3p	98.8434	NM_001042683
SHPRH	hsa-miR-374c-5p	98.7855	NM_001042683
SHPRH	hsa-miR-655-3p	98.7855	NM_001042683
SHPRH	hsa-miR-200a-5p	97.5553	NM_173082
SHPRH	hsa-miR-200b-5p	97.5553	NM_173082
SHPRH	hsa-miR-6739-5p	97.0927	NM_173082
SHPRH	hsa-miR-5582-3p	96.7289	NM_001042683
SHPRH	hsa-miR-6733-5p	95.2806	NM_173082
SHPRH	hsa-miR-4716-5p	94.9645	NM_173082
SHPRH	hsa-miR-186-5p	94.5183	NM_001042683
SHPRH	hsa-miR-3153	94.3864	NM_173082
SHPRH	hsa-miR-4789-3p	93.8437	NM_173082
SHPRH	hsa-miR-6507-3p	92.9184	NM_001042683
SHPRH	hsa-miR-190a-3p	92.292	NM_173082
SHPRH	hsa-miR-466	90.2636	NM_173082
SHPRH	hsa-miR-590-3p	89.6384	NM_173082
SHPRH	hsa-miR-548x-3p	88.6619	NM_173082
SHPRH	hsa-miR-548aj-3p	88.6619	NM_173082
SHPRH	hsa-miR-1302	88.5042	NM_001042683
SHPRH	hsa-miR-3913-5p	88.335	NM_001042683
SHPRH	hsa-miR-29a-3p	88.2342	NM_001042683
SHPRH	hsa-miR-29c-3p	88.2342	NM_001042683
SHPRH	hsa-miR-29b-3p	88.2342	NM_001042683
SHPRH	hsa-miR-3122	88.2186	NM_001042683
SHPRH	hsa-miR-600	87.8252	NM_173082
SHPRH	hsa-miR-329-5p	87.8019	NM_173082
SHPRH	hsa-miR-4298	87.1417	NM_001042683
SHPRH	hsa-miR-380-3p	87.1128	NM_173082
SHPRH	hsa-miR-144-3p	86.7208	NM_001042683
SHPRH	hsa-miR-10397-3p	86.1337	NM_001042683
SHPRH	hsa-miR-580-5p	85.3774	NM_173082
SHPRH	hsa-miR-122-5p	84.8651	NM_001042683
SHPRH	hsa-miR-7161-3p	84.7217	NM_001042683
SHPRH	hsa-miR-6069	84.3424	NM_173082
SHPRH	hsa-miR-548ar-3p	84.3259	NM_001042683
SHPRH	hsa-miR-6854-5p	84.0964	NM_173082
SHPRH	hsa-miR-4261	83.1727	NM_001042683
SHPRH	hsa-miR-548ae-3p	82.8012	NM_173082
SHPRH	hsa-miR-548j-3p	82.8012	NM_173082
SHPRH	hsa-miR-548ah-3p	82.8012	NM_173082
SHPRH	hsa-miR-548aq-3p	82.8012	NM_173082
SHPRH	hsa-miR-548am-3p	82.8012	NM_173082
SHPRH	hsa-miR-5688	82.7745	NM_173082
SHPRH	hsa-miR-495-3p	82.7745	NM_173082
SHPRH	hsa-miR-671-5p	82.6968	NM_173082
SHPRH	hsa-miR-548c-3p	82.4661	NM_001042683
SHPRH	hsa-miR-147b-5p	82.3775	NM_001042683
SHPRH	hsa-miR-374a-5p	82.2462	NM_173082
SHPRH	hsa-miR-374b-5p	81.7796	NM_173082

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Motifs and transcription factors (TFs) regulating SHPRH

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SHPRH	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
SHPRH	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
SHPRH	transfac_pro__M04617	ZBTB7A (directAnnotation).
SHPRH	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
SHPRH	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
SHPRH	transfac_pro__M07387	ZBTB7A (directAnnotation).
SHPRH	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
SHPRH	transfac_pro__M00716	ZBTB14 (directAnnotation).
SHPRH	hdpi__HIP2	UBE2K (directAnnotation).
SHPRH	transfac_pro__M04893	TAF1 (directAnnotation).
SHPRH	transfac_pro__M03876	ZBTB33 (directAnnotation).
SHPRH	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
SHPRH	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
SHPRH	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
SHPRH	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
SHPRH	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."