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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SHANK2

Summary for SHANK2

Gene information	Gene symbol	SHANK2
	Ensembl ID	ENSG00000162105
	Entrez ID	22941
	Gene name	SH3 and multiple ankyrin repeat domains 2
	Synonyms	CORTBP1\|CTTNBP1\|ProSAP1\|SHANK\|SPANK-3
	Gene type	protein_coding
	UniProtAcc	Q9UPX8

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Dataset with differentially expressed gene: SHANK2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	3.27313	2.40e-05

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Expression of SHANK2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SHANK2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SHANK2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SHANK2	hsa-miR-218-5p	98.6883	NM_012309
SHANK2	hsa-miR-3148	97.5211	NM_012309
SHANK2	hsa-miR-3926	97.4639	NM_012309
SHANK2	hsa-miR-6516-5p	97.2449	NM_012309
SHANK2	hsa-miR-6867-5p	95.6095	NM_012309
SHANK2	hsa-miR-5690	95.3567	NM_012309
SHANK2	hsa-miR-4251	95.0161	NM_012309
SHANK2	hsa-miR-202-3p	94.6981	NM_012309
SHANK2	hsa-miR-7-5p	94.6968	NM_012309
SHANK2	hsa-miR-10399-5p	94.4387	NM_012309
SHANK2	hsa-miR-6504-3p	94.4387	NM_012309
SHANK2	hsa-miR-4684-5p	93.8786	NM_012309
SHANK2	hsa-miR-3692-3p	93.8572	NM_012309
SHANK2	hsa-miR-301b-3p	93.7477	NM_012309
SHANK2	hsa-miR-4704-3p	93.4719	NM_012309
SHANK2	hsa-miR-454-3p	93.1508	NM_012309
SHANK2	hsa-miR-4295	92.7234	NM_012309
SHANK2	hsa-miR-130b-3p	92.7234	NM_012309
SHANK2	hsa-miR-301a-3p	92.7234	NM_012309
SHANK2	hsa-miR-3666	92.7234	NM_012309
SHANK2	hsa-miR-130a-3p	92.7234	NM_012309
SHANK2	hsa-miR-4701-5p	92.6499	NM_012309
SHANK2	hsa-miR-588	92.6499	NM_012309
SHANK2	hsa-miR-619-3p	91.7643	NM_012309
SHANK2	hsa-miR-5698	90.9168	NM_012309
SHANK2	hsa-miR-6079	89.7346	NM_012309
SHANK2	hsa-miR-656-5p	89.7306	NM_012309
SHANK2	hsa-miR-1273h-3p	89.6533	NM_012309
SHANK2	hsa-miR-3678-3p	89.5398	NM_012309
SHANK2	hsa-miR-11181-3p	89.3362	NM_012309
SHANK2	hsa-miR-765	89.3362	NM_012309
SHANK2	hsa-miR-651-3p	88.7721	NM_012309
SHANK2	hsa-miR-4716-5p	88.474	NM_012309
SHANK2	hsa-miR-302f	88.239	NM_012309
SHANK2	hsa-miR-7111-5p	87.8149	NM_012309
SHANK2	hsa-miR-6870-5p	87.8149	NM_012309
SHANK2	hsa-miR-4723-5p	87.8149	NM_012309
SHANK2	hsa-miR-519a-2-5p	87.6903	NM_012309
SHANK2	hsa-miR-520b-5p	87.6903	NM_012309
SHANK2	hsa-miR-7114-5p	87.4776	NM_012309
SHANK2	hsa-miR-4671-3p	86.9383	NM_012309
SHANK2	hsa-miR-190a-5p	86.8568	NM_012309
SHANK2	hsa-miR-190b-5p	86.8568	NM_012309
SHANK2	hsa-miR-6874-3p	86.5938	NM_012309
SHANK2	hsa-miR-3692-5p	86.5889	NM_012309
SHANK2	hsa-miR-346	86.5529	NM_012309
SHANK2	hsa-miR-506-3p	86.399	NM_012309
SHANK2	hsa-miR-124-3p	86.399	NM_012309
SHANK2	hsa-miR-148b-5p	86.3033	NM_012309
SHANK2	hsa-miR-6852-3p	85.6838	NM_012309

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Motifs and transcription factors (TFs) regulating SHANK2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."