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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SH3BP4

Summary for SH3BP4

Gene information	Gene symbol	SH3BP4
	Ensembl ID	ENSG00000130147
	Entrez ID	23677
	Gene name	SH3 domain binding protein 4
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q9P0V3

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Dataset with differentially expressed gene: SH3BP4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.252649	1.93e-10

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Expression of SH3BP4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SH3BP4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SH3BP4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SH3BP4	hsa-miR-8068	96.086	NM_014521
SH3BP4	hsa-miR-210-5p	95.6917	NM_014521
SH3BP4	hsa-miR-450a-2-3p	94.5268	NM_014521
SH3BP4	hsa-miR-4659b-3p	92.5984	NM_014521
SH3BP4	hsa-miR-4659a-3p	92.5984	NM_014521
SH3BP4	hsa-miR-3674	92.5638	NM_014521
SH3BP4	hsa-miR-103a-3p	91.1266	NM_014521
SH3BP4	hsa-miR-107	91.1266	NM_014521
SH3BP4	hsa-miR-544b	90.9745	NM_014521
SH3BP4	hsa-miR-4772-3p	88.6837	NM_014521
SH3BP4	hsa-miR-4496	87.7539	NM_014521
SH3BP4	hsa-miR-2110	87.6844	NM_014521
SH3BP4	hsa-miR-18b-5p	87.2541	NM_014521
SH3BP4	hsa-miR-18a-5p	87.2541	NM_014521
SH3BP4	hsa-miR-3915	87.2073	NM_014521
SH3BP4	hsa-miR-891b	87.1877	NM_014521
SH3BP4	hsa-miR-32-3p	86.5377	NM_014521
SH3BP4	hsa-miR-4735-3p	85.3388	NM_014521
SH3BP4	hsa-miR-3928-3p	84.6671	NM_014521
SH3BP4	hsa-miR-548t-5p	84.1371	NM_014521
SH3BP4	hsa-miR-548az-5p	84.1371	NM_014521
SH3BP4	hsa-miR-6769a-3p	82.6482	NM_014521
SH3BP4	hsa-miR-4651	82.1373	NM_014521
SH3BP4	hsa-miR-608	82.1373	NM_014521
SH3BP4	hsa-miR-153-3p	80.8224	NM_014521
SH3BP4	hsa-miR-1303	80.8113	NM_014521
SH3BP4	hsa-miR-3148	80.3777	NM_014521

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Motifs and transcription factors (TFs) regulating SH3BP4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SH3BP4	jaspar__MA0079.5	SP1 (directAnnotation).
SH3BP4	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
SH3BP4	transfac_pro__M01253	CNOT3 (directAnnotation).
SH3BP4	hdpi__NFIX	NFIX (directAnnotation).
SH3BP4	metacluster_153.4	SOX12; SOX14; SRY (directAnnotation). SOX5 (inferredBy_Orthology).
SH3BP4	transfac_pro__M04817	ZBTB33 (directAnnotation).
SH3BP4	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."