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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SH3BGRL2

Summary for SH3BGRL2

Gene information	Gene symbol	SH3BGRL2
	Ensembl ID	ENSG00000198478
	Entrez ID	83699
	Gene name	SH3 domain binding glutamate rich protein like 2
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q9UJC5

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Dataset with differentially expressed gene: SH3BGRL2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	2.3048	1.19e-03

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Expression of SH3BGRL2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SH3BGRL2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SH3BGRL2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SH3BGRL2	hsa-miR-4795-3p	98.2933	NM_031469
SH3BGRL2	hsa-miR-3163	97.8927	NM_031469
SH3BGRL2	hsa-miR-3613-3p	96.0748	NM_031469
SH3BGRL2	hsa-miR-8067	95.6811	NM_031469
SH3BGRL2	hsa-miR-6508-5p	95.5111	NM_031469
SH3BGRL2	hsa-miR-205-3p	94.5305	NM_031469
SH3BGRL2	hsa-miR-373-5p	94.2392	NM_031469
SH3BGRL2	hsa-miR-371b-5p	94.2392	NM_031469
SH3BGRL2	hsa-miR-616-5p	94.2392	NM_031469
SH3BGRL2	hsa-miR-1299	93.7155	NM_031469
SH3BGRL2	hsa-miR-4714-5p	93.1031	NM_031469
SH3BGRL2	hsa-miR-4766-5p	92.6793	NM_031469
SH3BGRL2	hsa-miR-12122	92.3048	NM_031469
SH3BGRL2	hsa-miR-4292	92.293	NM_031469
SH3BGRL2	hsa-miR-6791-5p	92.293	NM_031469
SH3BGRL2	hsa-miR-6809-5p	92.2594	NM_031469
SH3BGRL2	hsa-miR-31-5p	92.1256	NM_031469
SH3BGRL2	hsa-miR-656-3p	92.0522	NM_031469
SH3BGRL2	hsa-miR-371a-5p	91.8902	NM_031469
SH3BGRL2	hsa-miR-4728-3p	91.7169	NM_031469
SH3BGRL2	hsa-miR-1277-5p	91.3988	NM_031469
SH3BGRL2	hsa-miR-4742-5p	91.3855	NM_031469
SH3BGRL2	hsa-miR-216a-3p	91.219	NM_031469
SH3BGRL2	hsa-miR-128-3p	91.219	NM_031469
SH3BGRL2	hsa-miR-6516-3p	91.1033	NM_031469
SH3BGRL2	hsa-miR-5688	90.6932	NM_031469
SH3BGRL2	hsa-miR-3681-3p	90.5736	NM_031469
SH3BGRL2	hsa-miR-607	90.3331	NM_031469
SH3BGRL2	hsa-miR-495-3p	89.6465	NM_031469
SH3BGRL2	hsa-miR-3120-5p	89.3582	NM_031469
SH3BGRL2	hsa-miR-520d-5p	89.3372	NM_031469
SH3BGRL2	hsa-miR-524-5p	89.3372	NM_031469
SH3BGRL2	hsa-miR-5701	89.2102	NM_031469
SH3BGRL2	hsa-miR-10527-5p	88.8581	NM_031469
SH3BGRL2	hsa-miR-3182	88.5145	NM_031469
SH3BGRL2	hsa-miR-5002-5p	88.1741	NM_031469
SH3BGRL2	hsa-miR-1237-3p	87.9172	NM_031469
SH3BGRL2	hsa-miR-513b-5p	87.9157	NM_031469
SH3BGRL2	hsa-miR-620	87.4934	NM_031469
SH3BGRL2	hsa-miR-1270	87.4934	NM_031469
SH3BGRL2	hsa-miR-8077	87.2938	NM_031469
SH3BGRL2	hsa-miR-3148	87.1164	NM_031469
SH3BGRL2	hsa-miR-3124-3p	87.0163	NM_031469
SH3BGRL2	hsa-miR-6867-5p	86.894	NM_031469
SH3BGRL2	hsa-miR-6777-3p	86.0031	NM_031469
SH3BGRL2	hsa-miR-372-5p	85.9679	NM_031469
SH3BGRL2	hsa-miR-384	85.7361	NM_031469
SH3BGRL2	hsa-miR-3160-5p	85.1957	NM_031469
SH3BGRL2	hsa-miR-548an	84.2503	NM_031469
SH3BGRL2	hsa-miR-517-5p	84.1721	NM_031469

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Motifs and transcription factors (TFs) regulating SH3BGRL2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SH3BGRL2	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
SH3BGRL2	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
SH3BGRL2	transfac_pro__M04617	ZBTB7A (directAnnotation).
SH3BGRL2	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
SH3BGRL2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
SH3BGRL2	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
SH3BGRL2	transfac_pro__M07387	ZBTB7A (directAnnotation).
SH3BGRL2	transfac_pro__M07436	WT1 (directAnnotation).
SH3BGRL2	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
SH3BGRL2	transfac_pro__M00716	ZBTB14 (directAnnotation).
SH3BGRL2	hdpi__HIP2	UBE2K (directAnnotation).
SH3BGRL2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
SH3BGRL2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
SH3BGRL2	transfac_pro__M04893	TAF1 (directAnnotation).
SH3BGRL2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
SH3BGRL2	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
SH3BGRL2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SH3BGRL2	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."