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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SH2D1B

Summary for SH2D1B

Gene information	Gene symbol	SH2D1B
	Ensembl ID	ENSG00000198574
	Entrez ID	117157
	Gene name	SH2 domain containing 1B
	Synonyms	EAT2
	Gene type	protein_coding
	UniProtAcc	O14796

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Dataset with differentially expressed gene: SH2D1B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	NK cells	-0.29524	5.41e-35
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	NK cells	0.332725	1.70e-37
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	post	NK cells	-0.255971	1.48e-21

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Expression of SH2D1B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SH2D1B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SH2D1B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SH2D1B	hsa-miR-2052	90.7504	NM_053282
SH2D1B	hsa-miR-4425	88.9349	NM_053282
SH2D1B	hsa-miR-548c-3p	88.6694	NM_053282
SH2D1B	hsa-miR-12117	88.4423	NM_053282
SH2D1B	hsa-miR-4803	88.388	NM_053282
SH2D1B	hsa-miR-628-3p	87.8592	NM_053282
SH2D1B	hsa-miR-33a-3p	87.839	NM_053282
SH2D1B	hsa-miR-203a-3p	87.2241	NM_053282
SH2D1B	hsa-miR-4503	87.0973	NM_053282
SH2D1B	hsa-miR-6845-3p	86.7084	NM_053282
SH2D1B	hsa-miR-3529-3p	80.9041	NM_053282

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Motifs and transcription factors (TFs) regulating SH2D1B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SH2D1B	transfac_pro__M06007	ZNF69 (directAnnotation).
SH2D1B	metacluster_172.29	ZNF131 (directAnnotation). ZNF131 (inferredBy_Orthology).
SH2D1B	metacluster_11.1	ZNF667 (directAnnotation).
SH2D1B	kznf__ZNF285_Imbeault2017_OM_MEME	ZNF285 (directAnnotation).
SH2D1B	transfac_pro__M05539	OSR2 (inferredBy_Orthology).
SH2D1B	metacluster_23.5	WT1 (directAnnotation).
SH2D1B	transfac_pro__M06092	ZNF28 (directAnnotation).
SH2D1B	transfac_pro__M06723	ZNF492 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."