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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SGMS2

Summary for SGMS2

Gene information	Gene symbol	SGMS2
	Ensembl ID	ENSG00000164023
	Entrez ID	166929
	Gene name	sphingomyelin synthase 2
	Synonyms	MGC26963\|SMS2
	Gene type	protein_coding
	UniProtAcc	Q8NHU3

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Dataset with differentially expressed gene: SGMS2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.07925	0.00e+00

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Expression of SGMS2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SGMS2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SGMS2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SGMS2	hsa-miR-190a-3p	98.9739	NM_152621
SGMS2	hsa-miR-4328	98.4811	NM_152621
SGMS2	hsa-miR-5011-5p	97.4622	NM_152621
SGMS2	hsa-miR-548t-5p	97.0797	NM_001136257
SGMS2	hsa-miR-548az-5p	97.0797	NM_001136257
SGMS2	hsa-miR-9-5p	96.026	NM_001136257
SGMS2	hsa-miR-29c-3p	94.8178	NM_001136257
SGMS2	hsa-miR-29b-3p	94.8178	NM_001136257
SGMS2	hsa-miR-29a-3p	94.8178	NM_001136257
SGMS2	hsa-miR-4423-3p	93.934	NM_001136257
SGMS2	hsa-miR-133a-3p	92.8152	NM_001136257
SGMS2	hsa-miR-133b	92.8152	NM_001136257
SGMS2	hsa-miR-215-3p	91.9432	NM_152621
SGMS2	hsa-miR-5682	91.5863	NM_001136257
SGMS2	hsa-miR-548ah-5p	91.2998	NM_001136257
SGMS2	hsa-miR-3609	91.2998	NM_001136257
SGMS2	hsa-miR-3941	90.7552	NM_152621
SGMS2	hsa-miR-4277	90.5684	NM_001136257
SGMS2	hsa-miR-203a-3p	89.6926	NM_001136257
SGMS2	hsa-miR-153-3p	89.2214	NM_001136257
SGMS2	hsa-miR-3691-3p	88.986	NM_152621
SGMS2	hsa-miR-4282	88.5462	NM_152621
SGMS2	hsa-miR-3059-5p	88.3586	NM_152621
SGMS2	hsa-miR-6083	87.815	NM_152621
SGMS2	hsa-miR-186-5p	87.7648	NM_001136257
SGMS2	hsa-miR-433-3p	87.5581	NM_152621
SGMS2	hsa-miR-6881-3p	86.2132	NM_152621
SGMS2	hsa-miR-4256	85.9538	NM_152621
SGMS2	hsa-miR-11181-5p	85.9538	NM_152621
SGMS2	hsa-miR-6758-3p	84.1615	NM_152621
SGMS2	hsa-miR-30e-3p	84.0125	NM_001136257
SGMS2	hsa-miR-30a-3p	84.0125	NM_001136257
SGMS2	hsa-miR-30d-3p	84.0125	NM_001136257
SGMS2	hsa-miR-3664-3p	83.5335	NM_152621
SGMS2	hsa-miR-6880-5p	81.2824	NM_152621
SGMS2	hsa-miR-548c-3p	81.1739	NM_152621
SGMS2	hsa-miR-12136	81.0598	NM_001136257
SGMS2	hsa-miR-6782-3p	80.8615	NM_001136257
SGMS2	hsa-miR-548aj-3p	80.0545	NM_152621
SGMS2	hsa-miR-548x-3p	80.0545	NM_152621

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Motifs and transcription factors (TFs) regulating SGMS2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SGMS2	metacluster_135.11	NR2C2 (directAnnotation).
SGMS2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SGMS2	tfdimers__MD00038	TFAP2C (directAnnotation).
SGMS2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SGMS2	metacluster_7.13	ZFX (directAnnotation).
SGMS2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
SGMS2	cisbp__M00968	MTF2 (directAnnotation).
SGMS2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SGMS2	metacluster_160.20	JUND; PRDM15 (directAnnotation).
SGMS2	cisbp__M00341	PAX6 (directAnnotation).
SGMS2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
SGMS2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
SGMS2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
SGMS2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
SGMS2	cisbp__M00788	ZFY (inferredBy_Orthology).
SGMS2	metacluster_175.1	ZNF283 (directAnnotation).
SGMS2	hdpi__ZNF304	ZNF304 (directAnnotation).
SGMS2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
SGMS2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
SGMS2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SGMS2	transfac_pro__M01199	TRIM28 (directAnnotation).
SGMS2	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
SGMS2	metacluster_151.2	ZNF23 (directAnnotation).
SGMS2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SGMS2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SGMS2	transfac_pro__M03806	ZBTB7C (directAnnotation).
SGMS2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."