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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SGCB

Summary for SGCB

Gene information	Gene symbol	SGCB
	Ensembl ID	ENSG00000163069
	Entrez ID	6443
	Gene name	sarcoglycan beta
	Synonyms	A3b\|LGMD2E\|SGC
	Gene type	protein_coding
	UniProtAcc	Q16585

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Dataset with differentially expressed gene: SGCB

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.558216	1.67e-02

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Expression of SGCB in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SGCB

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SGCB

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SGCB	hsa-miR-5692a	99.8118	NM_000232
SGCB	hsa-miR-4318	98.5541	NM_000232
SGCB	hsa-miR-548c-3p	97.1269	NM_000232
SGCB	hsa-miR-101-5p	96.8435	NM_000232
SGCB	hsa-miR-224-5p	94.4956	NM_000232
SGCB	hsa-miR-1303	94.3191	NM_000232
SGCB	hsa-miR-3135a	94.25	NM_000232
SGCB	hsa-miR-1285-5p	94.0083	NM_000232
SGCB	hsa-miR-7158-5p	93.8295	NM_000232
SGCB	hsa-miR-152-3p	93.4805	NM_000232
SGCB	hsa-miR-148b-3p	93.4805	NM_000232
SGCB	hsa-miR-148a-3p	93.4805	NM_000232
SGCB	hsa-miR-4429	93.3255	NM_000232
SGCB	hsa-miR-320c	93.3255	NM_000232
SGCB	hsa-miR-320a-3p	93.3255	NM_000232
SGCB	hsa-miR-320d	93.3255	NM_000232
SGCB	hsa-miR-320b	93.3255	NM_000232
SGCB	hsa-miR-616-5p	92.1497	NM_000232
SGCB	hsa-miR-5696	91.7075	NM_000232
SGCB	hsa-miR-3925-5p	91.6425	NM_000232
SGCB	hsa-miR-2278	91.0241	NM_000232
SGCB	hsa-miR-5682	90.7468	NM_000232
SGCB	hsa-miR-373-5p	90.4331	NM_000232
SGCB	hsa-miR-371b-5p	90.4331	NM_000232
SGCB	hsa-miR-3613-3p	89.4906	NM_000232
SGCB	hsa-miR-4528	89.4027	NM_000232
SGCB	hsa-miR-4699-5p	89.2929	NM_000232
SGCB	hsa-miR-4666b	88.9596	NM_000232
SGCB	hsa-miR-548aw	88.0055	NM_000232
SGCB	hsa-miR-944	87.1846	NM_000232
SGCB	hsa-miR-1468-3p	86.4151	NM_000232
SGCB	hsa-miR-3121-3p	86.1841	NM_000232
SGCB	hsa-miR-3921	85.8772	NM_000232
SGCB	hsa-miR-4653-5p	85.8772	NM_000232
SGCB	hsa-miR-548x-5p	85.7193	NM_000232
SGCB	hsa-miR-548aj-5p	85.7193	NM_000232
SGCB	hsa-miR-548g-5p	85.7193	NM_000232
SGCB	hsa-miR-548f-5p	85.7193	NM_000232
SGCB	hsa-miR-5011-3p	85.5175	NM_000232
SGCB	hsa-miR-4795-3p	84.896	NM_000232
SGCB	hsa-miR-3662	83.99	NM_000232
SGCB	hsa-miR-3664-5p	83.0694	NM_000232
SGCB	hsa-miR-5701	82.5522	NM_000232
SGCB	hsa-miR-4310	82.3614	NM_000232
SGCB	hsa-miR-33b-5p	82.295	NM_000232
SGCB	hsa-miR-33a-5p	82.295	NM_000232
SGCB	hsa-miR-6857-5p	82.2337	NM_000232
SGCB	hsa-miR-4456	81.5155	NM_000232
SGCB	hsa-miR-377-3p	81.4358	NM_000232
SGCB	hsa-miR-548x-3p	80.8087	NM_000232

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Motifs and transcription factors (TFs) regulating SGCB

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SGCB	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
SGCB	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
SGCB	transfac_pro__M04617	ZBTB7A (directAnnotation).
SGCB	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
SGCB	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
SGCB	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
SGCB	transfac_pro__M07387	ZBTB7A (directAnnotation).
SGCB	transfac_pro__M07436	WT1 (directAnnotation).
SGCB	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
SGCB	transfac_pro__M00716	ZBTB14 (directAnnotation).
SGCB	swissregulon__hs__CHD1	CHD1 (directAnnotation).
SGCB	hdpi__HIP2	UBE2K (directAnnotation).
SGCB	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
SGCB	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
SGCB	transfac_pro__M04893	TAF1 (directAnnotation).
SGCB	transfac_pro__M03876	ZBTB33 (directAnnotation).
SGCB	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
SGCB	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SGCB	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
SGCB	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SGCB	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."