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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene (This gene does not contain this module)
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: SFTPD

Summary for SFTPD

Gene information	Gene symbol	SFTPD
	Ensembl ID	ENSG00000133661
	Entrez ID	6441
	Gene name	surfactant protein D
	Synonyms	COLEC7\|SFTP4\|SP-D
	Gene type	protein_coding
	UniProtAcc	P35247

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Dataset with differentially expressed gene: SFTPD

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	1.42486	1.00e-39

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Expression of SFTPD in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SFTPD

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Gene symbol	Cell type with DEG	Interaction ID	Interacting pair	Gene A	Gene B	Integrin	Interacting cell type1	Interacting cell type2	Dataset	Timepoint	Condition
SFTPD	Malignant cells	CPI-SS0305C793D	SFTPD_ADGRE5	SFTPD	ADGRE5	False	Malignant cells	B cells	GSE207422_Tor	post	resistant
SFTPD	Malignant cells	CPI-SS0305C793D	SFTPD_ADGRE5	SFTPD	ADGRE5	False	Malignant cells	CD4+ T cells	GSE207422_Tor	post	resistant
SFTPD	Malignant cells	CPI-SS0305C793D	SFTPD_ADGRE5	SFTPD	ADGRE5	False	Malignant cells	CD8+ T cells	GSE207422_Tor	post	resistant
SFTPD	Malignant cells	CPI-SS0305C793D	SFTPD_ADGRE5	SFTPD	ADGRE5	False	Malignant cells	Mast cells	GSE207422_Tor	post	resistant
SFTPD	Malignant cells	CPI-SS0305C793D	SFTPD_ADGRE5	SFTPD	ADGRE5	False	Malignant cells	Mono/Macro	GSE207422_Tor	post	resistant
SFTPD	Malignant cells	CPI-SS0305C793D	SFTPD_ADGRE5	SFTPD	ADGRE5	False	Malignant cells	NK cells	GSE207422_Tor	post	resistant
SFTPD	Malignant cells	CPI-SS0305C793D	SFTPD_ADGRE5	SFTPD	ADGRE5	False	Malignant cells	Neutrophils	GSE207422_Tor	post	resistant
SFTPD	Malignant cells	CPI-SS0305C793D	SFTPD_ADGRE5	SFTPD	ADGRE5	False	Malignant cells	Plasma cells	GSE207422_Tor	post	resistant
SFTPD	Malignant cells	CPI-SS0305C793D	SFTPD_ADGRE5	SFTPD	ADGRE5	False	Malignant cells	pDCs	GSE207422_Tor	post	resistant

Page: 1

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SFTPD

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

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Motifs and transcription factors (TFs) regulating SFTPD

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
SFTPD	"Beta-D-Glucose"	DB02379	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."