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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SFTPB

Summary for SFTPB

Gene information	Gene symbol	SFTPB
	Ensembl ID	ENSG00000168878
	Entrez ID	6439
	Gene name	surfactant protein B
	Synonyms	SFTP3\|SP-B
	Gene type	protein_coding
	UniProtAcc	P07988

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Dataset with differentially expressed gene: SFTPB

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	2.05493	2.38e-44

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Expression of SFTPB in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SFTPB

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SFTPB

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SFTPB	hsa-miR-3175	97.0622	NM_198843
SFTPB	hsa-miR-6842-5p	91.8756	NM_000542
SFTPB	hsa-miR-7110-5p	91.8756	NM_000542
SFTPB	hsa-miR-922	91.0277	NM_000542
SFTPB	hsa-miR-4291	90.4335	NM_000542
SFTPB	hsa-miR-4680-3p	89.9726	NM_000542
SFTPB	hsa-miR-6752-5p	88.1066	NM_000542
SFTPB	hsa-miR-6818-5p	87.4143	NM_198843
SFTPB	hsa-miR-6833-3p	87.3935	NM_198843
SFTPB	hsa-miR-5089-5p	84.6854	NM_198843
SFTPB	hsa-miR-6132	83.2388	NM_198843
SFTPB	hsa-miR-6776-5p	82.7244	NM_198843
SFTPB	hsa-miR-4768-5p	82.0577	NM_198843
SFTPB	hsa-miR-505-5p	81.8813	NM_198843
SFTPB	hsa-miR-7151-3p	81.8139	NM_198843
SFTPB	hsa-miR-934	81.7489	NM_198843
SFTPB	hsa-miR-8083	81.6471	NM_000542
SFTPB	hsa-miR-6829-5p	80.7362	NM_198843

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Motifs and transcription factors (TFs) regulating SFTPB

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."