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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SFT2D1

Summary for SFT2D1

Gene information	Gene symbol	SFT2D1
	Ensembl ID	ENSG00000198818
	Entrez ID	113402
	Gene name	SFT2 domain containing 1
	Synonyms	C6orf83\|MGC19825\|pRGR1
	Gene type	protein_coding
	UniProtAcc	Q8WV19

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Dataset with differentially expressed gene: SFT2D1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.719248	4.69e-07
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.496482	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.449571	3.04e-41
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	0.412736	9.46e-14
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.566225	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.426257	6.13e-34
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.46603	4.56e-24
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.473023	1.01e-34
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.379267	5.98e-20
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.395392	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.33585	0.00e+00

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Expression of SFT2D1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SFT2D1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SFT2D1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SFT2D1	hsa-miR-23c	99.3768	NM_145169
SFT2D1	hsa-miR-23a-3p	99.3768	NM_145169
SFT2D1	hsa-miR-23b-3p	99.3768	NM_145169
SFT2D1	hsa-miR-205-3p	95.9099	NM_145169
SFT2D1	hsa-miR-607	94.9798	NM_145169
SFT2D1	hsa-miR-548c-3p	94.2231	NM_145169
SFT2D1	hsa-miR-10527-5p	93.7486	NM_145169
SFT2D1	hsa-miR-656-3p	93.5784	NM_145169
SFT2D1	hsa-miR-548e-5p	92.7399	NM_145169
SFT2D1	hsa-miR-449b-5p	92.1629	NM_145169
SFT2D1	hsa-miR-34c-5p	92.1629	NM_145169
SFT2D1	hsa-miR-5579-3p	91.8972	NM_145169
SFT2D1	hsa-miR-548p	90.4683	NM_145169
SFT2D1	hsa-miR-34a-5p	90.2172	NM_145169
SFT2D1	hsa-miR-449a	90.2172	NM_145169
SFT2D1	hsa-miR-629-5p	89.0605	NM_145169
SFT2D1	hsa-miR-190a-3p	88.0769	NM_145169
SFT2D1	hsa-miR-561-3p	87.7201	NM_145169
SFT2D1	hsa-miR-3166	87.1729	NM_145169
SFT2D1	hsa-miR-559	87.0581	NM_145169
SFT2D1	hsa-miR-548ak	84.6559	NM_145169
SFT2D1	hsa-miR-548c-5p	84.6559	NM_145169
SFT2D1	hsa-miR-548ar-5p	84.6559	NM_145169
SFT2D1	hsa-miR-548au-5p	84.6559	NM_145169
SFT2D1	hsa-miR-548d-5p	84.6559	NM_145169
SFT2D1	hsa-miR-548h-5p	84.6559	NM_145169
SFT2D1	hsa-miR-548y	84.6559	NM_145169
SFT2D1	hsa-miR-548ad-5p	84.6559	NM_145169
SFT2D1	hsa-miR-548j-5p	84.6559	NM_145169
SFT2D1	hsa-miR-548aq-5p	84.6559	NM_145169
SFT2D1	hsa-miR-548ab	84.6559	NM_145169
SFT2D1	hsa-miR-548ap-5p	84.6559	NM_145169
SFT2D1	hsa-miR-548i	84.6559	NM_145169
SFT2D1	hsa-miR-548ae-5p	84.6559	NM_145169
SFT2D1	hsa-miR-548as-5p	84.6559	NM_145169
SFT2D1	hsa-miR-548a-5p	84.6559	NM_145169
SFT2D1	hsa-miR-548ay-5p	84.6559	NM_145169
SFT2D1	hsa-miR-548bb-5p	84.6559	NM_145169
SFT2D1	hsa-miR-548am-5p	84.6559	NM_145169
SFT2D1	hsa-miR-548o-5p	84.6559	NM_145169
SFT2D1	hsa-miR-548b-5p	84.6559	NM_145169
SFT2D1	hsa-miR-548w	84.6559	NM_145169
SFT2D1	hsa-miR-10399-5p	84.2283	NM_145169
SFT2D1	hsa-miR-6504-3p	84.2283	NM_145169
SFT2D1	hsa-miR-548l	83.7281	NM_145169
SFT2D1	hsa-miR-642b-3p	82.2694	NM_145169
SFT2D1	hsa-miR-642a-3p	82.2694	NM_145169
SFT2D1	hsa-miR-6124	81.5538	NM_145169
SFT2D1	hsa-miR-1273h-3p	81.0964	NM_145169
SFT2D1	hsa-miR-548at-5p	80.5148	NM_145169

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Motifs and transcription factors (TFs) regulating SFT2D1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SFT2D1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
SFT2D1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
SFT2D1	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
SFT2D1	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
SFT2D1	swissregulon__hs__ELF2	ELF2 (directAnnotation).
SFT2D1	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
SFT2D1	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
SFT2D1	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
SFT2D1	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
SFT2D1	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
SFT2D1	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
SFT2D1	jaspar__MA1708.1	ETV7 (directAnnotation).
SFT2D1	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
SFT2D1	taipale_tf_pairs__HOXD12_ETV1_RSCGGAAGTAATAAAN_CAP	ETV1; HOXD12 (directAnnotation).
SFT2D1	metacluster_79.34	GATA2; GATA5 (directAnnotation).
SFT2D1	transfac_pro__M06259	ZNF91 (directAnnotation).
SFT2D1	tfdimers__MD00147	ELF5; TFAP2C (directAnnotation).
SFT2D1	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
SFT2D1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
SFT2D1	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
SFT2D1	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
SFT2D1	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
SFT2D1	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
SFT2D1	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
SFT2D1	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
SFT2D1	jaspar__MA1957.1	ELK1 (directAnnotation).
SFT2D1	transfac_pro__M06331	ZNF343 (directAnnotation).
SFT2D1	swissregulon__hs__ELK1	ELK1 (directAnnotation).
SFT2D1	metacluster_183.4	ETS1 (inferredBy_Orthology).
SFT2D1	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
SFT2D1	swissregulon__hs__ETV6	ETV6 (directAnnotation).
SFT2D1	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
SFT2D1	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
SFT2D1	transfac_pro__M04748	GABPA (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."