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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SETD2

Summary for SETD2

Gene information	Gene symbol	SETD2
	Ensembl ID	ENSG00000181555
	Entrez ID	29072
	Gene name	SET domain containing 2, histone lysine methyltransferase
	Synonyms	FLJ23184\|HIF-1\|HYPB\|KIAA1732\|KMT3A
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SETD2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.294342	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.307692	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.36007	2.80e-45
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.417157	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.250104	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.261261	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.420796	1.10e-34

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Expression of SETD2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SETD2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SETD2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SETD2	hsa-miR-545-5p	96.9704	NM_014159
SETD2	hsa-miR-559	95.6023	NM_014159
SETD2	hsa-miR-548i	94.1107	NM_014159
SETD2	hsa-miR-548ab	94.1107	NM_014159
SETD2	hsa-miR-6792-5p	94.0746	NM_014159
SETD2	hsa-miR-548ak	93.6559	NM_014159
SETD2	hsa-miR-548bb-5p	93.6559	NM_014159
SETD2	hsa-miR-548ap-5p	93.6559	NM_014159
SETD2	hsa-miR-548ar-5p	93.6559	NM_014159
SETD2	hsa-miR-548as-5p	93.6559	NM_014159
SETD2	hsa-miR-548c-5p	93.6559	NM_014159
SETD2	hsa-miR-548aq-5p	93.6559	NM_014159
SETD2	hsa-miR-548b-5p	93.6559	NM_014159
SETD2	hsa-miR-548ad-5p	93.6559	NM_014159
SETD2	hsa-miR-548a-5p	93.6559	NM_014159
SETD2	hsa-miR-548d-5p	93.6559	NM_014159
SETD2	hsa-miR-548o-5p	93.6559	NM_014159
SETD2	hsa-miR-548w	93.6559	NM_014159
SETD2	hsa-miR-548y	93.6559	NM_014159
SETD2	hsa-miR-548ay-5p	93.6559	NM_014159
SETD2	hsa-miR-548h-5p	93.6559	NM_014159
SETD2	hsa-miR-548ae-5p	93.6559	NM_014159
SETD2	hsa-miR-548am-5p	93.6559	NM_014159
SETD2	hsa-miR-548au-5p	93.6559	NM_014159
SETD2	hsa-miR-548j-5p	93.6559	NM_014159
SETD2	hsa-miR-7-1-3p	92.7667	NM_014159
SETD2	hsa-miR-7-2-3p	92.7667	NM_014159
SETD2	hsa-miR-1261	92.2018	NM_014159
SETD2	hsa-miR-5000-5p	91.6322	NM_014159
SETD2	hsa-miR-12136	90.3666	NM_014159
SETD2	hsa-miR-6500-3p	89.3838	NM_014159
SETD2	hsa-miR-4722-5p	88.5969	NM_014159
SETD2	hsa-miR-4503	87.403	NM_014159
SETD2	hsa-miR-369-3p	87.1567	NM_014159
SETD2	hsa-miR-6823-5p	87.0632	NM_014159
SETD2	hsa-miR-548ah-5p	85.6127	NM_014159
SETD2	hsa-miR-3609	85.6127	NM_014159
SETD2	hsa-miR-548aa	85.4815	NM_014159
SETD2	hsa-miR-548ap-3p	85.4815	NM_014159
SETD2	hsa-miR-548t-3p	85.4815	NM_014159
SETD2	hsa-miR-548e-5p	84.3039	NM_014159
SETD2	hsa-miR-222-5p	81.7273	NM_014159
SETD2	hsa-miR-7108-5p	80.7537	NM_014159

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Motifs and transcription factors (TFs) regulating SETD2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SETD2	metacluster_135.11	NR2C2 (directAnnotation).
SETD2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SETD2	tfdimers__MD00038	TFAP2C (directAnnotation).
SETD2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SETD2	metacluster_7.13	ZFX (directAnnotation).
SETD2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
SETD2	cisbp__M00968	MTF2 (directAnnotation).
SETD2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SETD2	metacluster_160.20	JUND; PRDM15 (directAnnotation).
SETD2	cisbp__M00341	PAX6 (directAnnotation).
SETD2	metacluster_198.3	ZFP64 (directAnnotation).
SETD2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
SETD2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
SETD2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
SETD2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
SETD2	cisbp__M00788	ZFY (inferredBy_Orthology).
SETD2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SETD2	metacluster_175.1	ZNF283 (directAnnotation).
SETD2	hdpi__ZNF304	ZNF304 (directAnnotation).
SETD2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
SETD2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
SETD2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SETD2	transfac_pro__M01199	TRIM28 (directAnnotation).
SETD2	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
SETD2	metacluster_151.2	ZNF23 (directAnnotation).
SETD2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SETD2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SETD2	transfac_pro__M03806	ZBTB7C (directAnnotation).
SETD2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SETD2	transfac_pro__M02913	SP140 (inferredBy_Orthology).
SETD2	jaspar__MA0748.2	YY2 (directAnnotation).
SETD2	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
SETD2	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
SETD2	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
SETD2	transfac_pro__M00430	E2F1 (directAnnotation).
SETD2	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
SETD2	transfac_pro__M04893	TAF1 (directAnnotation).
SETD2	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
SETD2	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
SETD2	transfac_pro__M08894	OVOL1; OVOL2 (directAnnotation).
SETD2	hdpi__HIP2	UBE2K (directAnnotation).
SETD2	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
SETD2	hdpi__TIMELESS	TIMELESS (directAnnotation).
SETD2	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
SETD2	metacluster_191.5	SPDEF (inferredBy_Orthology).
SETD2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
SETD2	transfac_pro__M00938	E2F1 (directAnnotation).
SETD2	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
SETD2	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
SETD2	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."